Repetitive Er:YAG laser irradiation of human skin: A histological evaluation

Drnovšek-Olup, Brigita; Beltram, Matej; Pižem, Jože

doi:10.1002/lsm.20080

Cited by 71 publications

(53 citation statements)

References 25 publications

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“…Vacuolization may be a sign of edema, which usually occurs with Er:YAG laser resurfacing [4,9]. Polymononuclear cell infiltration observed in the TEM image after 15 J/cm 2 treatment indicates an inflammatory phase, which is responsible for degradation of damaged tissue [23]. Cytokeratins, a family of fibrous intermediate-filament protein polymers, are involved in epithelial structural maintenance, protection from mechanical trauma, and possibly communication between adjacent cells and cytoplasm components.…”

Section: Discussionmentioning

confidence: 98%

Systematic evaluations of skin damage irradiated by an erbium:YAG laser: Histopathologic analysis, proteomic profiles, and cellular response

Pan

Wang

Lee

et al. 2010

Journal of Dermatological Science

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Section: Discussionmentioning

confidence: 98%

Systematic evaluations of skin damage irradiated by an erbium:YAG laser: Histopathologic analysis, proteomic profiles, and cellular response

Pan

Wang

Lee

et al. 2010

Journal of Dermatological Science

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“…This seems beneficial in regions of the face where severe elastosis is the prevailing reason for rhytide formation (e.g., the upper lip) and with higher epidermis thickness, but less so in the peri-orbital region. Moreover, stacking of repetitive Er:YAG laser pulses has been demonstrated to cause deep collagen denaturation and remodeling on human lid skin despite the limited thermal exposure [39].…”

Section: Discussionmentioning

confidence: 99%

Ablative fractional lasers (CO₂ and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides

et al. 2010

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Background and Objective: Ablative fractional lasers were introduced for treating facial rhytides in an attempt to achieve results comparable to traditional ablative resurfacing but with fewer side effects. However, there is conflicting evidence on how well this goal has generally been achieved as well as on the comparative value of fractional CO 2 and Er:YAG lasers. The present study compares these modalities in a randomized controlled double-blind split-face study design. Study Design/Materials and Methods: Twenty-eight patients were enrolled and completed the entire study. Patients were randomly assigned to receive a single treatment on each side of the peri-orbital region, one with a fractional CO 2 and one with a fractional Er:YAG laser. The evaluation included the profilometric measurement of wrinkle depth, the Fitzpatrick wrinkle score (both before and 3 months after treatment) as well as the assessment of side effects and patient satisfaction (1, 3, 6 days and 3 months after treatment). Results: Both modalities showed a roughly equivalent effect. Wrinkle depth and Fitzpatrick score were reduced by approximately 20% and 10%, respectively, with no appreciable difference between lasers. Side effects and discomfort were slightly more pronounced after Er:YAG treatment in the first few days, but in the later course there were more complaints following CO 2 laser treatment. Patient satisfaction was fair and the majority of patients would have undergone the treatment again without a clear preference for either method. Conclusions: According to the present study, a single ablative fractional treatment session has an appreciable yet limited effect on peri-orbital rhytides. When fractional CO 2 and Er:YAG lasers are used in such a manner that there are comparable post-operative healing periods, comparable cosmetic improvement occurs. Multiple sessions may be required for full effect, which cancels out the proposed advantage of fractional methods, that is, fewer side effects and less down time.

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“…Esta absorción produce interacciones fotoquímicas, fototérmicas y fotomecánicas en los tejidos. En las mucosas se ha demostrado que el láser no ablativo Er:YAG estimula la producción de proteínas de matriz y fibroblastos, generando contracción de las fibras de colágeno y cambios tróficos que se manifiestan en tejidos con mayor grosor, hidratación y tensión (24)(25)(26)(27)(28).…”

Section: Discussionunclassified

Láser erbium vaginal como tratamiento del síndrome genitourinario de la menopausia: resultados preliminares

Gambacciani

2015

Rev. chil. obstet. ginecol.

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RESUMENAntecedentes: El síndrome genitourinario de la menopausia (SGM) afecta hasta el 50% de las mujeres posmenopáusicas. Sus síntomas presentan un curso crónico y progresivo, pudiendo alterar significativamente la sexualidad y la calidad de vida. Objetivo: Evaluar efectividad a corto plazo y aceptabilidad del láser vaginal de Erbium en cristal de itrio-aluminio-granate (Er:YAG) como una terapia fototérmica no invasiva, no ablativa para el manejo del SGM. Método: Estudio longitudinal prospectivo, realizado en 28 mujeres posmenopáusicas con SGM. Se aplica láser vaginal Er:YAG en 3 sesiones cada 30 días. En todos los controles, se evalúa sequedad vaginal, dispareunia mediante escala visual analógica, y se registra el "vaginal health index score" (VHIS). Al final del tratamiento se evalúa la aceptabilidad del método. Resultados: Se observa mejoría significativa de los síntomas (sequedad vaginal y dispareunia; p<0,01) durante todo el periodo de estudio y del VHIS (8,2 ± 1,3 previo al tratamiento vs. 19,2 ± 0,4 posterior al tratamiento; p<0,01). El 93,4% de las pacientes calificó el procedimiento como excelente o bueno. Conclusión: Nuestro estudio piloto muestra que el tratamiento con láser Er:YAG en mujeres posmenopáusicas con síntomas de SGM es eficaz, factible y seguro en el corto plazo. Se requieren datos a más largo plazo y de mayor tamaño muestral para confirmar nuestros resultados.PALABRAS CLAVE: Menopausia, estrógenos, láser Erbium, atrofia vulvovaginal, síndrome genitourinario de la menopausia SUMMARY Background:The genitourinary syndrome of menopause (GSM) affects up to 50% of postmenopausal women. Symptoms are chronic and likely worsen over time. This complains may interfere with sexual function and quality of life. Objective: To evaluate the short-term effectiveness and acceptability of Erbium in yttrium aluminum-garnet crystal Laser (Er:YAG) as a non-invasive, non-ablative photothermal therapy for the treatment of GSM. Methods: Prospective longitudinal study performed in 28 postmenopausal women suffering from GSM. All participants were treated intravaginally with Er:YAG laser in 3 applications performed every 30 days. Symptoms (vaginal dryness and dyspareunia) were evaluated by a visual-analogic scale (VAS) and the vaginal health index score (VHIS). After therapy, the women were asked to evaluate the acceptability of the intervention. Results: Er:YAG laser treatment was effective to improve symptoms (vaginal dryness and dyspareunia; p<0.01) at all the study period, as well the VHIS (8.2 ± 1.3 at baseline vs. 19.2 ± 0.4 after treatment; p<0.01). Satisfaction with the procedure was reported as excellent or good by 93.4% of women. Conclusion: Our pilot study shows that the Er:YAG treatment in postmenopausal women with GSM is effective, feasible, and safe. Further larger, long-term and controlled studies are required to confirm this data.

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Repetitive Er:YAG laser irradiation of human skin: A histological evaluation

Abstract: Repetitive Er:YAG laser irradiation is effective in deep denaturation and remodeling of human skin collagen in vivo, with less epidermal damage compared to standard Er:YAG laser skin resurfacing.

Cited by 71 publications

References 25 publications

Systematic evaluations of skin damage irradiated by an erbium:YAG laser: Histopathologic analysis, proteomic profiles, and cellular response

Systematic evaluations of skin damage irradiated by an erbium:YAG laser: Histopathologic analysis, proteomic profiles, and cellular response

Ablative fractional lasers (CO₂ and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides

Láser erbium vaginal como tratamiento del síndrome genitourinario de la menopausia: resultados preliminares

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Repetitive Er:YAG laser irradiation of human skin: A histological evaluation

Abstract: Repetitive Er:YAG laser irradiation is effective in deep denaturation and remodeling of human skin collagen in vivo, with less epidermal damage compared to standard Er:YAG laser skin resurfacing.

Cited by 71 publications

References 25 publications

Systematic evaluations of skin damage irradiated by an erbium:YAG laser: Histopathologic analysis, proteomic profiles, and cellular response

Systematic evaluations of skin damage irradiated by an erbium:YAG laser: Histopathologic analysis, proteomic profiles, and cellular response

Ablative fractional lasers (CO2 and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides

Láser erbium vaginal como tratamiento del síndrome genitourinario de la menopausia: resultados preliminares

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Ablative fractional lasers (CO₂ and Er:YAG): A randomized controlled double‐blind split‐face trial of the treatment of peri‐orbital rhytides