“…This is what would be necessary in order to measure a condition-specific change in correlation/coupling cleanly, with correlation/coupling between two brain regions being calculated over the set of individual stimulus responses in each experimental condition (e.g., novel versus repeated). One solution would be to use a blocked design with no temporal overlap of the novel and repeated conditions, although that has wellknown downsides, creating problems of interpretation with respect to strategic effects and differences in attentional state (e.g., D'Esposito, Zarahn, & Aguirre, 1999;Hamburger & Slowiaczek, 1998). A better 236 GOTTS, CHOW, MARTIN solution would be to space individual stimuli far enough apart such that the peaks of the BOLD responses are no longer overlapping (,8-10 s, closer to a "slow" eventrelated design; e.g., Bandettini & Cox, 2000), still permitting randomly interleaved conditions.…”