Repercussions of intraalveolar placement of combination of 0.2% chlorhexidine and 10 Mg metronidazole gel on the 
occurrence of dry sockets- A randomized control trial

Kaur, Jasleen; Raval, Rushik; Bansal, Anupam; Kumawat, Vinod

doi:10.4317/jced.53262

Cited by 11 publications

(11 citation statements)

References 20 publications

(24 reference statements)

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“…Therefore, since no other studies in the field of oral surgery have used a SOS, the present study carried out the first comparison of this compound with the gold standard used in these situations, chlorhexidine. Multiple studies can support this affirmation that chlorhexidine is the gold standard ( 27 , 28 ).…”

Section: Discussionmentioning

confidence: 92%

“…In the study group, the combination of metronidazole with chlorhexidine gel was introduced. In the study group, the incidence of alveolitis was significantly reduced, from 22.6% to 6.6% ( p ≤ 0.001); therefore, they concluded that the intraalveolar use of this gel decreases the incidence of adverse reactions and complications related to the extraction of lower third molars ( 28 ).…”

Section: Discussionmentioning

confidence: 92%

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Postoperative effects on lower third molars of using mouthwashes with super-oxidized solution versus 0.2% chlorhexidine gel: A randomized double-blind trial

Coello-Gómez¹,

Navarro-Suárez²,

Diosdado-Cano³

et al. 2018

Med Oral

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BackgroundThe main objective of the present study is to evaluate the effects and possible benefits with regard to the postoperative period of lower third molar extractions, comparing the intraalveolar application of a bioadhesive gel of 0.2% chlorhexidine (CHX) to the use of a mouthwash with a super-oxidized solution, (SOS) Dermacyn® Wound Care (Oculus Innovative Sciences lnc., California, USA).Material and MethodsA randomized double-blind study was carried out in 20 patients with a split-mouth design, with a total of 40 extractions of symmetrically impacted bilateral lower third molars. Patients were divided into two groups, a control group (C = 20) and an experimental group (D = 20). Any infectious complications, wound healing, plaque accumulation in the stitches, and presence of trismus and inflammation were evaluated using the distance between different facial points, at three, eight, and fifteen days after extraction. Pain, swelling, and amount of analgesics taken were evaluated using the VAS scale throughout the 15 days following extraction. Tolerance to treatment was evaluated using a verbal scale. Results were statistically compared using the Student’s t- and chi-squared tests.ResultsNo statistically significant differences were found between the two groups with regard to infectious complications, swelling, or wound healing. Use of analgesics and self-reported pain levels were slightly lower in the experimental group than in the control group during days 6 and 7 of the study (p<0.05). The global treatment tolerance was satisfactory and similar in both groups.ConclusionsBoth CHX and SOS are effective at improving the postoperative period after extraction of lower third molars. Key words:Lower third molar, postoperative, chlorhexidine gel, super-oxidized solution, wound healing.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 92%

Postoperative effects on lower third molars of using mouthwashes with super-oxidized solution versus 0.2% chlorhexidine gel: A randomized double-blind trial

Coello-Gómez¹,

Navarro-Suárez²,

Diosdado-Cano³

et al. 2018

Med Oral

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“…Epidemiological studies have revealed several contradictory risk factors in the development of post-extraction alveolitis: surgical trauma as a consequence of the difficulty in extraction and/or inexperience of the surgeon, inadequate intraoperative irrigation, use of oral contraceptives and/or immunosuppression, advanced age, female sex and smoking. However, the true causes of the condition are not known [ 2 , 7 , 19 , 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Prevention of Dry Socket with Ozone Oil-Based Gel after Inferior Third Molar Extraction: A Double-Blind Split-Mouth Randomized Placebo-Controlled Clinical Trial

Materni

Pasquale

Longo

et al. 2023

Gels

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Tooth extraction is followed by a sequence of elaborate local changes affecting hard and soft tissues. Dry socket (DS) can occur as intense pain around and in the extraction site, with an incidence from 1–4% after generic tooth extraction to 45% for mandibular third molars. Ozone therapy has gained attention in the medical field because of its success in the treatment of various diseases, its biocompatible properties and its fewer side effects or discomfort than drugs. To investigate the preventive effect of the sunflower oil-based ozone gel Ozosan® (Sanipan srl, Clivio (VA), Italy) on DS, a double-blind split-mouth randomized placebo-controlled clinical trial was conducted according to the CONSORT guidelines. Ozosan® or the placebo gel were put in the socket, and the gels were washed off 2 min later. In total, 200 patients were included in our study. The patient population comprised 87 Caucasian males and 113 Caucasian females. The mean age of the included patients was 33.1 ± 12.4 years. Ozosan reduced the incidence of DS after inferior third molar extraction from 21.5% of the control to 2% (p < 0.001). Concerning the dry socket epidemiology, the incidence was not significantly correlated with gender, smoking or mesioangular, vertical or distoangular Winter’s classification. Post hoc power calculation showed a power of 99.8% for this data, with alpha = 0.001.

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“…CHX gluconate gel 0.2% is characterized by higher bioadhesive properties and is more effective than CHX gluconate solution 0.12% Hita-Iglesias et al [97] . What is more, the results of the meta-analysis showed that using topical metronidazole and CHX gel is effective in reducing AO [98] .…”

Section: Chlorhexidinementioning

confidence: 96%

Alveolar osteitis: the current state of knowledge

Dryla

Szymoniuk

Rogatko

et al. 2022

J Educ Health Sport

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Introduction and purpose: Alveolar osteitis, also known as dry socket is a common complication after tooth extraction, especially third molar extraction. Taking into consideration only third molar extractions, the prevalence of dry socket reaches even 45%. The aim of this literature review was to describe current knowledge about etiology, risk factors, treatment, and prevention of dry socket. State of knowledge: The symptoms of alveolar osteitis most frequently are reported between the first and third post-extraction days and they include discomfort, lancing, and intense pain which radiates to the neck and ear. The etiopathogenesis of dry socket remains unclear. However, the currently accepted hypothesis describes a loss of formed after an extraction blood clot from the alveolar socket as the main cause of this pathology. Several factors may increase the risk of dry socket and include smoking, oral hygiene, female gender, oral contraceptive drugs, and anesthesia. In the treatment of alveolar osteitis, irrigation of the socket with chlorhexidine gluconate, iodopovidone, or physiological saline followed by filling the socket with intra-alveolar dressing constitute a current fundamental procedure. Plenty of substances are currently used as an intra-alveolar dressing. Part of them exhibits only pain-decreasing features, whereas some drugs can also stimulate the regeneration of treated tissue. In the prevention, the use of alveolar osteitis warm saline, antibiotics, chlorhexidine, ozone gas, or autologous platelet therapy may be useful maneuvers. Conclusion: This literature review summarizes the current state of knowledge about causes, risk factors, and therapeutic and preventive methods with regard to alveolar osteitis.

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Repercussions of intraalveolar placement of combination of 0.2% chlorhexidine and 10 Mg metronidazole gel on the occurrence of dry sockets- A randomized control trial

Cited by 11 publications

References 20 publications

Postoperative effects on lower third molars of using mouthwashes with super-oxidized solution versus 0.2% chlorhexidine gel: A randomized double-blind trial

Postoperative effects on lower third molars of using mouthwashes with super-oxidized solution versus 0.2% chlorhexidine gel: A randomized double-blind trial

Prevention of Dry Socket with Ozone Oil-Based Gel after Inferior Third Molar Extraction: A Double-Blind Split-Mouth Randomized Placebo-Controlled Clinical Trial

Alveolar osteitis: the current state of knowledge

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