Repeating an abnormal prostate-specific antigen (PSA) level: how relevant is a decrease in PSA?

Connolly, David; Murray, Liam; Nambirajan, Thiagarajan; Keane, Patrick F.; Gavin, Anna

doi:10.1038/pcan.2008.37

Cited by 10 publications

(9 citation statements)

References 17 publications

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“…PSA-related markers can fluctuate, and even cases with a decreasing trend in PSA derivatives may have cancerous tissues [30]. Moreover, prostate infection alters PSA values [31,32,33]. …”

Section: Discussionmentioning

confidence: 99%

Management of Men with a Suspicion of Prostate Cancer after Negative Initial Prostate Biopsy Results

et al. 2014

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Introduction: For men with elevated prostate-specific antigen (PSA), appropriate management after negative prostate biopsy remains controversial. After determining PSA kinetics, subsequent follow-up was considered. Patients and Methods: A total of 115 cases with negative repeat biopsy were followed by evaluating PSA kinetics and ratio of percent free PSA (F/T) and by performing second repeat biopsy. Results: Eighteen cancer cases were diagnosed. Shorter PSA doubling times and faster velocities were found in cancer cases compared with cases without cancer. We observed a clear decrease in F/T among cancer cases. Conclusions: To avoid unnecessary repeat biopsies, cases with a suspicion of cancer after negative biopsy can be divided into two groups: one that requires additional biopsies and one with an average change in PSA of <1 ng/ml/year and no change in F/T, which is recommended for surveillance as stable disease without biopsy over a specified time period.

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“…PSA-related markers can fluctuate, and even cases with a decreasing trend in PSA derivatives may have cancerous tissues [30]. Moreover, prostate infection alters PSA values [31,32,33]. …”

Section: Discussionmentioning

confidence: 99%

Management of Men with a Suspicion of Prostate Cancer after Negative Initial Prostate Biopsy Results

et al. 2014

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“…Further, previous analyses of the NI PSA database have not shown any systematic bias in PSA results from any laboratory. [9][10][11] Other limitations of the data in the NI PSA database have previously been discussed. [9][10][11] In addition, regional weather data only are presented.…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11] Other limitations of the data in the NI PSA database have previously been discussed. [9][10][11] In addition, regional weather data only are presented. NI is a small region with similar weather patterns throughout the province; therefore, local differences in weather parameters are unlikely to be significant.…”

Section: Discussionmentioning

confidence: 99%

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Daily, monthly and seasonal variation in PSA levels and the association with weather parameters

Connolly

Leeuwen²,

Bailie

et al. 2010

Prostate Cancer Prostatic Dis

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PSA levels have shown daily and seasonal variation, although data are conflicting regarding the season with higher PSA levels and the clinical relevance of this. We assessed the correlation of total PSA levels with meteorological data on a daily, weekly, monthly and seasonal basis. Data from 53 224 men aged 45-74 years, with an initial PSA o10.0 ng ml À1 were correlated with temperature (1C), duration of bright sunshine (hours) and rainfall (mm). There was seasonal variation in PSA levels, with median PSA being higher in spring compared with other seasons (1.18 vs 1.10 ng ml À1 , P ¼ 0.004). Seasonal variation was not apparent when PSA levels were age-adjusted (P ¼ 0.112). Total PSA was not correlated with daily, weekly or monthly hours of sunshine, rainfall or mean temperature. In contrast, age-adjusted PSA varied with weekday, with higher PSA levels on Thursday and Friday compared with other days (1.16 vs 1.10 ng ml À1 , respectively). On multivariate analysis, only age predicted for PSA levels 43.0 ng ml À1 . In conclusion, PSA levels did show seasonal variation, although there was no direct correlation between PSA and any meteorological parameter. The degree of seasonal variation is small and the decision to proceed to prostate biopsy should be independent of season or weather parameters.

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“…Prostate cancer accounted for 10-10·4% of deaths from cancer among all cancer patients in 2008, and it is the most common cancer among men (Ferlay et al, 2007;Jemal et al, 2008). There are two common screenings for prostate cancer: the prostate-specific antigen (PSA) test and the digital rectal examination (DRE) (Connolly et al, 2008). There are two common screenings for prostate cancer: the prostate-specific antigen (PSA) test and the digital rectal examination (DRE) (Connolly et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Factors influencing southern Taiwanese men's acceptance of prostate-specific antigen screening

Lin

Cheng

et al. 2011

International Journal of Urological Nursing

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Prostate‐specific antigen (PSA) testing is a common screening among adult men for early awareness of prostate cancer. Although prostate cancer is the seventh most common cause of death from cancer in males in Taiwan in 2008, this testing is still unpopular in Taiwanese society. The purpose of this study was to explore the prevalence of acceptance of PSA testing and related factors in Taiwanese males. A cross‐sectional study was conducted. The sample population was recruited from two counties in southern Taiwan. Three hundred and thirty male participants completed the structured questionnaire. The following outcomes were studied: patient profiles, knowledge of PSA screening, acceptance of PSA testing, the reasons for acceptance of PSA testing and history of benign prostate hypertrophy (BPH). The results indicated that 29·4% of the respondents reported having had a PSA test. The logistic regression model showed age, having heard of PSA testing, BPH history and annual income to be the statistically significant factors. The odds of accepting PSA testing increased 9·56‐fold in men with a history of BPH compared with men without a BPH history. Acceptance of PSA testing increased 7·98‐fold in patients who had heard of PSA testing compared with those participants who had not heard of PSA testing. The odds of accepting PSA testing increased 4·43‐fold in patients aged 56–65 years, 8·14‐fold in those aged 66–75 years and 11·20‐fold in those older than 76 years when compared with men younger than 55 years. This study shows that male acceptance of PSA testing is still not popular in Taiwan. The results can help health care providers to take the responsibility for seeking appropriate strategies to improve the rate of acceptance of PSA testing.

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Repeating an abnormal prostate-specific antigen (PSA) level: how relevant is a decrease in PSA?

Cited by 10 publications

References 17 publications

Management of Men with a Suspicion of Prostate Cancer after Negative Initial Prostate Biopsy Results

Management of Men with a Suspicion of Prostate Cancer after Negative Initial Prostate Biopsy Results

Daily, monthly and seasonal variation in PSA levels and the association with weather parameters

Factors influencing southern Taiwanese men's acceptance of prostate-specific antigen screening

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