Repeatedly reactivated memories become more resistant to hippocampal damage

Lehmann, Hugo; McNamara, Kathryn C.

doi:10.1101/lm.2000811

Cited by 24 publications

(21 citation statements)

References 45 publications

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“…In contrast, we found that a less intense conditioning and more spaced reactivation protocol led to a prolonged period of hippocampus memory dependence. This discrepancy between our findings and that of Lehmann and McNamara (2011) may be due to methodological differences (lesioning vs. pharmacological inactivation) and different time intervals between reactivation and testing (3 weeks vs. 1 week). Another possibility is that massed memory reactivation soon after training may enable extra-hippocampal structures to encode the fear memory similar to multi-day overtraining, whereas a more spaced protocol, as used in our study, impedes systems consolidation and maintains the memory in a detailed, hippocampus dependent state.…”

contrasting

confidence: 81%

“…These studies suggest that overtraining of contextual fear discrimination allows extrahippocampal structures to encode the memory, thus shortening or avoiding a period of time that memory expression is sensitive to hippocampal manipulations. Interestingly, a recent study found that following a strong training protocol (10 shocks) and a more intense memory reactivation schedule (23 a day for 5 days), memory was rendered insensitive to hippocampal lesions when tested in the training context (Lehmann and McNamara, 2011). This study did not test the context-specificity of the memory expression.…”

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confidence: 89%

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Periodically reactivated context memory retains its precision and dependence on the hippocampus

et al. 2011

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Hippocampus is hypothesized to play a temporary role in the retrieval of context memories. Similarly, previous studies have reported that the expression of context memories becomes more generalized as memory ages. We report, first, that contextual fear memory expression changes from being sensitive to dorsal hippocampus inactivation by muscimol at 2 days post-conditioning, to insensitive at 28 days, and second, that over the same period rats lose their ability to discriminate between a novel and conditioned context. Furthermore, we show that repeated brief memory reactivation sessions prevent memory from becoming both hippocampus-independent and generalized.

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confidence: 81%

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confidence: 89%

Periodically reactivated context memory retains its precision and dependence on the hippocampus

et al. 2011

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“…Some previous work has implicated medial frontal cortex in successful long-term memory. For example, medial prefrontal cortex has been implicated in systems-level consolidation of memories in humans (Takashima et al, 2007;Sterpenich et al, 2009;van Kesteren et al, 2010) and in rodents (Frankland and Bontempi, 2005;Restivo et al, 2009;Lehmann and McNamara, 2011). Also, Eriksson et al (2011) demonstrated a relationship between longterm retention after successful repeated retrieval and medial prefrontal cortex activity (in dorsal medial PFC/ACC).…”

Section: Day 1 Bold Signal Changes In Relation To Successful Longtermmentioning

confidence: 99%

Lesser Neural Pattern Similarity across Repeated Tests Is Associated with Better Long-Term Memory Retention

Wirebring

Wiklund-Hörnqvist

Eriksson

et al. 2015

Journal of Neuroscience

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Encoding and retrieval processes enhance long-term memory performance. The efficiency of encoding processes has recently been linked to representational consistency: the reactivation of a representation that gets more specific each time an item is further studied. Here we examined the complementary hypothesis of whether the efficiency of retrieval processes also is linked to representational consistency. Alternatively, recurrent retrieval might foster representational variability-the altering or adding of underlying memory representations. Human participants studied 60 Swahili-Swedish word pairs before being scanned with fMRI the same day and 1 week later. On Day 1, participants were tested three times on each word pair, and on Day 7 each pair was tested once. A BOLD signal change in right superior parietal cortex was associated with subsequent memory on Day 1 and with successful long-term retention on Day 7. A representational similarity analysis in this parietal region revealed that beneficial recurrent retrieval was associated with representational variability, such that the pattern similarity on Day 1 was lower for retrieved words subsequently remembered compared with those subsequently forgotten. This was mirrored by a monotonically decreased BOLD signal change in dorsolateral prefrontal cortex on Day 1 as a function of repeated successful retrieval for words subsequently remembered, but not for words subsequently forgotten. This reduction in prefrontal response could reflect reduced demands on cognitive control. Collectively, the results offer novel insights into why memory retention benefits from repeated retrieval, and they suggest fundamental differences between repeated study and repeated testing.

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“…For example, in the conditioned place preference task, amnestic treatments disrupted reconsolidation for weak memories (four pairings), but had little effect on stronger memories (eight pairings) reactivated 1 d after training (Robinson and Franklin 2010). In the fear conditioning task, an increase of training strength by increasing the number of CS -US associations makes the reactivated memory trace less susceptible to interference (Suzuki et al 2004;Lehmann and McNamara 2011). However, it has been reported that strong memories can still be destabilized and then undergo reconsolidation relatively to their age (Wang et al 2009), suggesting that boundary conditions to the reconsolidation process can be in interaction.…”

mentioning

confidence: 99%

Characterization of spatial memory reconsolidation

Jaeger¹,

Courtey²,

Brus³

et al. 2014

Learn. Mem.

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Reconsolidation is necessary for the restabilization of reactivated memory traces. However, experimental parameters have been suggested as boundary conditions for this process. Here we investigated the role of a spatial memory trace's age, strength, and update on the reconsolidation process in mice. We first found that protein synthesis is necessary for reconsolidation to occur in the hippocampal CA3 region after reactivation of partially acquired and old memories but not for strongly acquired and recent memories. We also demonstrated that the update of a previously stable memory required, again, a memory reconsolidation in the hippocampal CA3. Finally, we found that the reactivation of a strongly acquired memory requires an activation of the anterior cingulate cortex as soon as 24 h after acquisition. This study demonstrates the importance of the knowledge of the task on the dynamic nature of memory reconsolidation processing.

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Repeatedly reactivated memories become more resistant to hippocampal damage

Cited by 24 publications

References 45 publications

Periodically reactivated context memory retains its precision and dependence on the hippocampus

Periodically reactivated context memory retains its precision and dependence on the hippocampus

Lesser Neural Pattern Similarity across Repeated Tests Is Associated with Better Long-Term Memory Retention

Characterization of spatial memory reconsolidation

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