Repeated vagus nerve stimulation produces anxiolytic effects via upregulation of AMPAR function in centrolateral amygdala of male rats

Zhang, Shao-Qi; Xia, Zhi-Xuan; Deng, Qiao; Yang, Ping-Fen; Long, Li‐Hong; Wang, Fang; Chen, Jianguo

doi:10.1016/j.ynstr.2022.100453

Cited by 2 publications

(2 citation statements)

References 66 publications

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“…Signals were obtained through a MultiClamp 700B amplifier (Molecular Devices, CA, USA) and acquired with pCLAMP10 software (Axon Instruments, Molecular Devices, CA, USA). Series resistance was monitored during recording, and data were discarded for those altered by > 20% 91 . Data were analyzed by the Mini Analysis Program (Synaptosoft, GA, USA).…”

Section: Methodsmentioning

confidence: 99%

Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression

Zhang,

Deng,

Zhu

et al. 2023

Cell Discov

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Dysfunctional autophagy and impairment of adult hippocampal neurogenesis (AHN) each contribute to the pathogenesis of major depressive disorder (MDD). However, whether dysfunctional autophagy is linked to aberrant AHN underlying MDD remains unclear. Here we demonstrate that the expression of nuclear receptor binding factor 2 (NRBF2), a component of autophagy-associated PIK3C3/VPS34-containing phosphatidylinositol 3-kinase complex, is attenuated in the dentate gyrus (DG) under chronic stress. NRBF2 deficiency inhibits the activity of the VPS34 complex and impairs autophagic flux in adult neural stem cells (aNSCs). Moreover, loss of NRBF2 disrupts the neurogenesis-related protein network and causes exhaustion of aNSC pool, leading to the depression-like phenotype. Strikingly, overexpressing NRBF2 in aNSCs of the DG is sufficient to rescue impaired AHN and depression-like phenotype of mice. Our findings reveal a significant role of NRBF2-dependent autophagy in preventing chronic stress-induced AHN impairment and suggest the therapeutic potential of targeting NRBF2 in MDD treatment.

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Section: Methodsmentioning

confidence: 99%

Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression

Zhang,

Deng,

Zhu

et al. 2023

Cell Discov

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“…These neuroanatomical pathways are critically involved in various psychiatric disorders. Chronic stimulation of the vagus nerve (VNS) produces an anxiolytic effect by enhancing excitatory neurotransmission [ 17 ], mediated by the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR). Concurrently, transcutaneous auricular VNS has been demonstrated as an efficacious and safe technique for reducing depression scores, showing comparable effectiveness to traditional antidepressants [ 18 ].…”

Section: Brain and Intestinal Microbiotic Interaction: A Molecular Pe...mentioning

confidence: 99%

Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders

Toader,

Dobrin,

Costea

et al. 2024

IJMS

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Psychiatric disorders represent a primary source of disability worldwide, manifesting as disturbances in individuals’ cognitive processes, emotional regulation, and behavioral patterns. In the quest to discover novel therapies and expand the boundaries of neuropharmacology, studies from the field have highlighted the gut microbiota’s role in modulating these disorders. These alterations may influence the brain’s processes through the brain–gut axis, a multifaceted bidirectional system that establishes a connection between the enteric and central nervous systems. Thus, probiotic and prebiotic supplements that are meant to influence overall gut health may play an insightful role in alleviating psychiatric symptoms, such as the cognitive templates of major depressive disorder, anxiety, or schizophrenia. Moreover, the administration of psychotropic drugs has been revealed to induce specific changes in a microbiome’s diversity, suggesting their potential utility in combating bacterial infections. This review emphasizes the intricate correlations between psychiatric disorders and the gut microbiota, mentioning the promising approaches in regard to the modulation of probiotic and prebiotic treatments, as well as the antimicrobial effects of psychotropic medication.

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Repeated vagus nerve stimulation produces anxiolytic effects via upregulation of AMPAR function in centrolateral amygdala of male rats

Cited by 2 publications

References 66 publications

Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression

Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression

Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders

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