Repeated treatment with the kappa opioid receptor agonist U69593 reverses enhanced K+ induced dopamine release in the nucleus accumbens, but not the expression of locomotor sensitization in amphetamine-sensitized rats

Escobar, A; Cornejo, Francisca; Andrés, Marı́a Estela; Fuentealba, José Antonio

doi:10.1016/j.neuint.2012.01.014

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…This suggests KORs control extracellular dopamine to alter rewarding effects of food. In the NAc, KOR activation during nicotine exposure 173 and amphetamine withdrawal 174 decreased basal and evoked dopamine, while KOR antagonism attenuated alcohol self-administration during withdrawal 175 . Furthermore, acute stress promoted TNFα in the amygdala, and amygdalar TNFα potentiated anxiety during withdrawal that was blocked by CRF antagonism 176 .…”

Section: Neuroinflammation Interacts With Stress To Modulate Dopamine...mentioning

confidence: 98%

Obesity and dietary fat influence dopamine neurotransmission: exploring the convergence of metabolic state, physiological stress, and inflammation on dopaminergic control of food intake

Wallace

Fordahl

2021

Nutr. Res. Rev.

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The aim of this review is to explore how metabolic changes induced by diets high in saturated fat (HFD) affect nucleus accumbens (NAc) dopamine neurotransmission and food intake, and to explore how stress and inflammation influence this process. Recent evidence linked diet-induced obesity and HFD with reduced dopamine release and reuptake. Altered dopamine neurotransmission could disrupt satiety circuits between NAc dopamine terminals and projections to the hypothalamus. The NAc directs learning and motivated behaviours based on homeostatic needs and psychological states. Therefore, impaired dopaminergic responses to palatable food could contribute to weight gain by disrupting responses to food cues or stress, which impacts type and quantity of food consumed. Specifically, saturated fat promotes neuronal resistance to anorectic hormones and activation of immune cells that release proinflammatory cytokines. Insulin has been shown to regulate dopamine neurotransmission by enhancing satiety, but less is known about effects of diet-induced stress. Therefore, changes to dopamine signalling due to HFD warrant further examination to characterise crosstalk of cytokines with endocrine and neurotransmitter signals. A HFD promotes a proinflammatory environment that may disrupt neuronal endocrine function and dopamine signalling that could be exacerbated by the hypothalamic-pituitary-adrenal and κ-opioid receptor stress systems. Together, these adaptive changes may dysregulate eating by changing NAc dopamine during hedonic versus homeostatic food intake. This could drive palatable food cravings during energy restriction and hinder weight loss. Understanding links between HFD and dopamine neurotransmission will inform treatment strategies for diet-induced obesity and identify molecular candidates for targeted therapeutics.

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Section: Neuroinflammation Interacts With Stress To Modulate Dopamine...mentioning

confidence: 98%

Obesity and dietary fat influence dopamine neurotransmission: exploring the convergence of metabolic state, physiological stress, and inflammation on dopaminergic control of food intake

Wallace

Fordahl

2021

Nutr. Res. Rev.

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“…Repeated quinpirole administration primes cocaine-induced stereotyped behavior (Thompson et al, 2010) and the locomotor effects of amphetamine (Cope et al, 2010), strengthening the idea that D2Rs activation underlie psychostimulant-induced sensitization and suggesting a shared mechanism between quinpirole and psychostimulants-induced sensitization. Interestingly, the sensitizing effect of repeated D2Rs activation seems to be stronger than that induced by psychostimulants, since every rat treated with quinpirole develop locomotor sensitization (Escobar et al, 2015), while around sixty percent of rats sensitize to amphetamine (Escobar et al, 2012;Casanova et al, 2013).…”

Section: Quinpirole-induced Locomotor Sensitization and Compulsive Bementioning

confidence: 99%

Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors

et al. 2020

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The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence

Clark

Abi‐Dargham

2019

Biological Psychiatry

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Schizophrenia is a debilitating mental illness that affects approximately 1% of the world's population. Despite much research in its neurobiology to aid in developing new treatments, little progress has been made. One system that has not received adequate attention is the kappa opioid system and its potential role in the emergence of symptoms, as well as its therapeutic potential. Here we present an overview of the kappa system and review various lines of evidence derived from clinical studies for dynorphin and kappa opioid receptor involvement in the pathology of both the positive and negative symptoms of schizophrenia. This overview includes evidence for the psychotomimetic effects of kappa opioid receptor agonists in healthy volunteers and their reversal by the pan-opioid antagonists naloxone and naltrexone and evidence for a therapeutic benefit in schizophrenia for 4 pan-opioid antagonists. We describe the interactions between kappa opioid receptors and the dopaminergic pathways that are disrupted in schizophrenia and the histologic evidence suggesting abnormal kappa opioid receptor signaling in schizophrenia. We conclude by discussing future directions.

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Repeated treatment with the kappa opioid receptor agonist U69593 reverses enhanced K+ induced dopamine release in the nucleus accumbens, but not the expression of locomotor sensitization in amphetamine-sensitized rats

Cited by 8 publications

References 29 publications

Obesity and dietary fat influence dopamine neurotransmission: exploring the convergence of metabolic state, physiological stress, and inflammation on dopaminergic control of food intake

Obesity and dietary fat influence dopamine neurotransmission: exploring the convergence of metabolic state, physiological stress, and inflammation on dopaminergic control of food intake

Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors

The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence

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