Repeated transcranial magnetic stimulation prevents kindling-induced changes in electrophysiological properties of rat hippocampal CA1 pyramidal neurons

Shojaei, Amir; Semnanian, Saeed; Janahmadi, Mahyar; Moradi-Chameh, Homeira; Firoozabadi, Seyed Mohammad; Mirnajafi‐Zadeh, Javad

doi:10.1016/j.neuroscience.2014.09.022

Cited by 21 publications

(16 citation statements)

References 75 publications

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“…Previous study in our lab showed that application of rTMS following kindling stimulations prevents the kindlinginduced potentiation in the synaptic plasticity (Yadollahpour et al, 2014). In addition, it decreases the seizure-induced changes in some electrophysiological properties of hippocampal CA1 pyramidal neurons (Shojaei et al, 2014). To complete and confirm our previous studies other electrophysiological parameters were addressed in this study.…”

Section: Discussionsupporting

confidence: 62%

“…Previous studies on human showed that application of lowfrequency rTMS led to decrement in neuronal excitability and had anticonvulsant effect (Bae et al, 2007;Chen et al, 1997;Fregni et al, 2005;Hsu et al, 2011;Joo et al, 2007;Sun et al, 2011Sun et al, , 2012Tergau et al, 1999). The anticonvulsant action of rTMS has been also observed in laboratory models of epilepsy, including amygdala kindling (Akamatsu et al, 2001;Anschel et al, 2003;Fleischmann et al, 1999;Lin et al, 2014;Mongabadi et al, 2013;Rotenberg et al, 2008;Shojaei et al, 2014;Yadollahpour et al, 2014). The mechanisms of these effects may be similar to those involved in induction of longterm depression or depotentiation (Chen et al, 1997;Hallett, 2000;Hoffman and Cavus, 2002;Kobayashi and PascualLeone, 2003;Tokay et al, 2009).…”

Section: Introductionmentioning

confidence: 94%

“…rTMS (1 Hz for 4 min) was applied at 5 min after the end of kindling stimulation as described previously (Shojaei et al, 2014;Yadollahpour et al, 2014). Briefly, the animals were exposed to CO 2 during the application of rTMS.…”

Section: Rtms Applicationmentioning

confidence: 99%

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Effect of low frequency repetitive transcranial magnetic stimulation on kindling-induced changes in electrophysiological properties of rat CA1 pyramidal neurons

et al. 2015

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 94%

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Effect of low frequency repetitive transcranial magnetic stimulation on kindling-induced changes in electrophysiological properties of rat CA1 pyramidal neurons

et al. 2015

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“…TMS is known to induce persistent changes in hippocampal synaptic plasticity in in vivo 27 , 37 and in vitro 28 , 29 . TMS-based in vivo studies have primarily focused on finding methods to treat neurodegenerative 27 , 38 , 39 or psychiatric diseases 40 . In vitro TMS experiments investigated the effects used to control the signal pathway of specific synaptic proteins 41 , as well as changes in the functional and structural plasticity of postsynapses in organotypic cultured slices 30 , 31 , 42 or acute slices 28 , 29 , 43 .…”

Section: Discussionmentioning

confidence: 99%

Planar coil-based contact-mode magnetic stimulation: synaptic responses in hippocampal slices and thermal considerations

Park

Kang

et al. 2018

Sci Rep

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Implantable magnetic stimulation is an emerging type of neuromodulation using coils that are small enough to be implanted in the brain. A major advantage of this method is that stimulation performance could be sustained even though the coil is encapsulated by gliosis due to foreign body reactions. Magnetic fields can induce indirect electric fields and currents in neurons. Compared to transcranial magnetic stimulation, the coil size used in implantable magnetic stimulation can be greatly reduced. However, the size reduction is accompanied by an increase in coil resistance. Hence, the coil could potentially damage neurons from the excess heat generated. Therefore, it is necessary to study the stimulation performance and possible thermal damage by implantable magnetic stimulation. Here, we devised contact-mode magnetic stimulation (CMS), wherein magnetic stimulation was applied to hippocampal slices through a customized planar-type coil underneath the slice in the contact mode. With acute hippocampal slices, we investigated the synaptic responses to examine the field excitatory postsynaptic responses of CMS and the temperature rise during CMS. A long-lasting synaptic depression was exhibited in the CA1 stratum radiatum after CMS, while the temperature remained in a safe range so as not to seriously affect the neural responses.

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“…Abbreviations: AD, afterdischarge; AM, amygdala; AK, amygdaloid kindling; CSF, cerebrospinal fluid; SE, status epilepticus; TFS, transcranial focal electrical stimulation; TCRE, tripolar concentric ring electrodes; tDCS, transcranial direct current stimulation.. (Faria et al, 2012;Santiago-Rodríguez et al, 2008) and in experimental animal models of temporal lobe epilepsy (Kamida et al, 2011;Shojaei et al, 2014). Despite these non-invasive antiepileptic treatments, the best structures to stimulate and the most effective stimuli to use are still unknown (Theodore and Fisher, 2007).…”

Section: Introductionmentioning

confidence: 99%

Transcranial focal electrical stimulation via concentric ring electrodes in freely moving cats: Antiepileptogenic and postictal effects

Valdés-Cruz

Villasana‐Salazar

Williams

et al. 2019

Experimental Neurology

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Transcranial focal electrical stimulation (TFS) via tripolar concentric ring electrodes (TCRE), tripolar TFS, is proposed to treat pharmacoresistant epilepsy. We determined the effect of tripolar TFS on electrical amygdaloid kindling (AK) in freely moving cats. Fifteen cats were bilaterally implanted with electrodes in the amygdala (AM) and prefrontal cortex and assigned to three groups: the control group, which only received AK; the tripolar TFS before AK group, in which TCREs were placed over the vertex and tripolar TFS (300 Hz, 200 μs biphasic equal charge, square pulses) was delivered for 40 min just prior to AK; and the tripolar TFS after AK group, in which the TCREs were placed over the temporal bone ipsilateral to the kindled AM, while tripolar TFS was administered for 2 min just after AK onset for 40 days, and, thereafter, only AK was applied. AK was applied daily until all animals reached kindling stage VI. A three concentric spheres finite element cat head model was developed to analyze the electric fields caused by tripolar TFS. Tripolar TFS after AK inhibited kindling development. Animals with tripolar TFS after AK remained at the focal seizure stages for 20 days after tripolar TFS cessation and required 80.0 ± 15.42 AK stimulations to reach stage VI, significantly higher than TFS before AK, and control (P < .001). Tripolar TFS before AK did not show signs of protection against epileptogenesis. The finite modeling of tripolar TFS showed that the electric field is >0.3 mV/mm at depths less than approximately 12.6 mm in the cat brain, which should be strong enough to alter brain activity. In conclusion, tripolar TFS applied via a TCRE over the ipsilateral temporal area significantly delayed AK. This taken together with other reports of tripolar TFS aborting seizures in acute seizure models suggests that tripolar TFS is a promising new modality that should be considered for further testing.

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Repeated transcranial magnetic stimulation prevents kindling-induced changes in electrophysiological properties of rat hippocampal CA1 pyramidal neurons

Cited by 21 publications

References 75 publications

Effect of low frequency repetitive transcranial magnetic stimulation on kindling-induced changes in electrophysiological properties of rat CA1 pyramidal neurons

Effect of low frequency repetitive transcranial magnetic stimulation on kindling-induced changes in electrophysiological properties of rat CA1 pyramidal neurons

Planar coil-based contact-mode magnetic stimulation: synaptic responses in hippocampal slices and thermal considerations

Transcranial focal electrical stimulation via concentric ring electrodes in freely moving cats: Antiepileptogenic and postictal effects

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