Repeated swimming stress and responsiveness of the isolated rat pacemaker to the chronotropic effect of noradrenaline and isoprenaline: Role of adrenal corticosteroids

Spadari, Regina Célia; Moraes, Suzana Alves de

doi:10.1016/0306-3623(88)90163-2

Cited by 31 publications

(12 citation statements)

References 16 publications

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“…Forty-eight hours after the last exercise session, the rats were anaesthetized under halothane, and blood was immediately collected from left renal vein (Spadari and De Moraes, 1988) into sterilized glass tubes (B&D 4.5 mL) with EDTA and into sterilized glass-gel tubes (B&D 4 mL). Thirty minutes after collection, blood was centrifuged (15 minutes, 2500 rpm) and plasma or serum was isolated.…”

Section: Blood Sampling Tissue Collection and Analytic Methodsmentioning

confidence: 99%

Influence of high-intensity exercise training and anabolic androgenic steroid treatment on rat tissue glycogen content

et al. 2005

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Section: Blood Sampling Tissue Collection and Analytic Methodsmentioning

confidence: 99%

Influence of high-intensity exercise training and anabolic androgenic steroid treatment on rat tissue glycogen content

et al. 2005

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“…Current intensity was 1.0 mA and duration was 1.0 s at random intervals of 5-25 s (mean interval of 15 s). The rats were returned to their cages at the end of each footshock session (10)(11)(12)(13).…”

Section: Stress Proceduresmentioning

confidence: 99%

“…Using a footshock stress paradigm (7), we demonstrated that ß-adrenergic receptor signaling was altered in cardiac and adipose tissues of stressed rats (6)(7)(8)(9)(10). Altered myocardial adrenergic receptor signaling has been demonstrated in several models of cardiac disease such as heart failure (11,12) and ischemic heart disease (12), and these pathologies had been associated with stress (13).…”

Section: Introductionmentioning

confidence: 99%

Metabolic markers following beta-adrenoceptor agonist infusion in footshock-stressed rats

Verago

Kassisse

Spadari-Bratfisch

2001

Braz J Med Biol Res

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Stress hormones can alter metabolic functions in adipose tissue and liver, as well as the sensitivity of rat white adipocytes and rat atrial responses to ß-adrenergic agonists. In this study, we examined the effects of three daily footshock stress sessions on the plasma corticosterone, glucose, glycerol and triacylglycerol levels of fed, conscious male rats, and on the plasma glucose, glycerol and triacylglycerol levels of the same rats following iv infusions of ß-adrenergic agonists (isoproterenol: 0.4 nmol kg -1 min -1 , noradrenaline: 5.0 µg kg -1 day -1 , and BRL 37344 ([±]-[4-(2-[(2-[3-chlorophenyl]-2-hydroxyethyl) amino]propyl)phenoxy]acetic acid), a selective ß 3 -adrenoceptor agonist: 0.4 nmol kg -1 min -1 ). Plasma corticosterone levels increased significantly after each stress session, while triacylglycerol levels increased after the first session and glucose increased after the second and third sessions. Glycerol levels were unaltered after stress. These results suggest that repeated footshock stress may induce a metabolic shift from triacylglycerol biosynthesis to glucose release by hepatic tissue, with glycerol serving as one of the substrates in both pathways. Stressed rats were more sensitive to infusion of noradrenaline plus prazosin and to infusion of isoproterenol, with elevated plasma glucose, glycerol and triacylglycerol levels. The higher sensitivity of stressed rats to isoproterenol and noradrenaline was probably related to the permissive effect of plasma corticosterone. Only BRL 37344 increased plasma glycerol levels in stressed rats, probably because ß 3 -adrenoceptors are not involved in hepatic triacylglycerol synthesis, thus allowing glycerol to accumulate in plasma.

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“…The trained or sedentary animals were anesthetized by halothane inhalation (22) . Median laparotomy and puncture of the left renal vein was performed to collect blood (23) tubes under vacuum, containing EDTA (B&D ® No. 367653), for obtaining plasma afterwards.…”

Section: Materials Collection and Biochemical Analysesmentioning

confidence: 99%

Relação entre a administração de esteróide anabólico androgênico, treinamento físico aeróbio e supercompensação do glicogênio

Cunha

Tanno

Moura

et al. 2005

Rev Bras Med Esporte

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A supercompensação do glicogênio é uma das adaptações induzidas pelo treinamento físico. Visando potencializar este fenômeno, muitos atletas utilizam doses suprafisiológicas de esteróides anabólicos androgênicos (EAA). O objetivo deste estudo foi avaliar em ratos os efeitos da nandrolona e do exercício aeróbio sobre o peso corporal, triglicerídeos, glicose e reservas de glicogênio. Ratos Wistar machos foram aleatoriamente divididos em quatro grupos: sedentário + veículo (SV), treinado + veículo (TV), sedentário + EAA (SEAA) e treinado + EAA (TEAA, n = 7-14/grupo). Receberam injeção i.m. de nandrolona ou veículo durante nove semanas e durante o mesmo período os animais treinados foram submetidos a exercício aeróbio. Os dados foram analisados por ANOVA bifatorial e Tukey (p < 0,05). Os grupos SEAA, TV e TEAA apresentaram menor peso corporal do que o grupo SV (SEAA: 339 ± 10 = TV: 342 ± 14 = TEAA: 332 ± 6 < SV: 398 ± 9g). O treinamento físico reduziu significativamente a concentração plasmática de triglicerídeos [(TV: 46 ± 4 = TEAA: 44 ± 3) < (SV: 104 ± 1 = SEAA: 101 ± 6mg/dL)] e de glicogênio hepático [(TV: 3,38 ± 0,57 = TEAA: 2,62 ± 0,34) < (SV: 4,95 ± 0,11 = SEAA: 4,43 ± 0,23mg/100mg)] e aumentou a concentração cardíaca de glicogênio [(TV: 0,38 ± 0,04 = TEAA: 0,42 ± 0,03) > (SV: 0,2 ± 0,02 = SEAA: 0,21 ± 0,02mg/100mg)]. A glicemia e as reservas de glicogênio do sóleo permaneceram inalteradas. O uso de doses suprafisiológicas de nandrolona não potencializou nenhum dos efeitos obtidos em resposta ao treinamento aeróbio.

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Repeated swimming stress and responsiveness of the isolated rat pacemaker to the chronotropic effect of noradrenaline and isoprenaline: Role of adrenal corticosteroids

Cited by 31 publications

References 16 publications

Influence of high-intensity exercise training and anabolic androgenic steroid treatment on rat tissue glycogen content

Influence of high-intensity exercise training and anabolic androgenic steroid treatment on rat tissue glycogen content

Metabolic markers following beta-adrenoceptor agonist infusion in footshock-stressed rats

Relação entre a administração de esteróide anabólico androgênico, treinamento físico aeróbio e supercompensação do glicogênio

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