Repeated surveillance of exposure to cadmium, manganese, and arsenic in school-age children living in rural, urban, and nonferrous smelter areas in Belgium

Buchet, Jean‐Pierre; Roels, Harry; Lauwerys, Robert; Bruaux, P.; Claeys-Thoreau, F.; Lafontaine, A; Verduyn, G.

doi:10.1016/0013-9351(80)90122-x

Cited by 71 publications

(43 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The children's methylation indices were consistent with those measured in children in Mexico and Belgium (27,28). In contrast, they were not consistent with the low %MMA reported in one study from Argentina (25).…”

Section: Discussioncontrasting

confidence: 46%

Family correlations of arsenic methylation patterns in children and parents exposed to high concentrations of arsenic in drinking water.

Chung

Kalman

Moore

et al. 2002

Environ Health Perspect

109

View full text Add to dashboard Cite

We investigated the evidence of a familial contribution to urinary methylation patterns in families ingesting arsenic in drinking water. Arsenic methylation can be assessed by measuring urinary levels of inorganic arsenic (InAs) and its methylated metabolites, monomethylarsonate (MMA), and dimethylarsinate (DMA). Methylation activity is reflected in the ratios: InAs/methylated arsenic (InAs/metAs) and MMA/DMA. Eleven families from Chile were selected because of their long-term exposure to very high levels of arsenic in drinking water (735-762 microg/L). Each family consisted of a father, a mother, and two children. We measured urinary arsenic and its methylated metabolites for each participant (n = 44). The intraclass correlation coefficients showed that 13-52% of the variations in the methylation patterns were from being a member of a specific family. Family correlations were calculated for father-mother, parent-child, and sibling-sibling pairs. Methylation patterns correlated strongly between siblings [r = 0.78 for InAs/metAs, 95% confidence interval (CI), 0.34-0.94; r = 0.82 for MMA/DMA, 95%CI, 0.43-0.95] compared to lower correlations in father-mother pairs (r = 0.18, r = -0.01, respectively), after adjustment for total urinary arsenic, age, and sex. Family correlations were not notably altered when adjustments were made for specific blood micronutrients (methionine, homocysteine, folate, vitamin B6, selenium, and vitamin B12 potentially related to methylation. We also report on a family pedigree with high prevalence of arsenic-induced effects. Participants from this family had low InAs/metAs values, which is consistent with increased toxicity of trivalent methylated arsenic species. Despite our small sample size, we observed that methylation patterns aggregate in families and are correlated in siblings, providing evidence of a genetic basis for the variation in arsenic methylation. Larger studies with more extensive pedigrees will need to be conducted to confirm these findings.

show abstract

Section: Discussioncontrasting

confidence: 46%

Family correlations of arsenic methylation patterns in children and parents exposed to high concentrations of arsenic in drinking water.

Chung

Kalman

Moore

et al. 2002

Environ Health Perspect

109

View full text Add to dashboard Cite

show abstract

“…The rate of excretion in urine depends on the chemical form of arsenic, the duration of exposure, and the species exposed. in humans exposed to a single low dose of arsenite, about 35 percent was excreted in urine over a period of 48 hours (Buchet et al, 1980;198 1). In the case of continuous human intake over a few days, 60…”

Section: The Major Route Of Excretion Following Human Exposure T O Inmentioning

confidence: 99%

Baseline risk assessment of ground water contamination at the uranium mill tailings site near Riverton, Wyoming. Revision 1

1995

View full text Add to dashboard Cite

“…The excretion rate in urine varies, depending on the chemical form of arsenic and the species exposed. In humans exposed t o a single low dose of arsenite, about 35 percent was excreted in urine over a period of 48 hours (Buchet et al, 1980;1981 …”

Section: Arsenic Absordtionmentioning

confidence: 99%

Baseline risk assessment of ground water contamination at the uranium mill tailings site near Lakeview, Oregon. Revision 1

1995

View full text Add to dashboard Cite

Repeated surveillance of exposure to cadmium, manganese, and arsenic in school-age children living in rural, urban, and nonferrous smelter areas in Belgium

Cited by 71 publications

References 18 publications

Family correlations of arsenic methylation patterns in children and parents exposed to high concentrations of arsenic in drinking water.

Family correlations of arsenic methylation patterns in children and parents exposed to high concentrations of arsenic in drinking water.

Baseline risk assessment of ground water contamination at the uranium mill tailings site near Riverton, Wyoming. Revision 1

Baseline risk assessment of ground water contamination at the uranium mill tailings site near Lakeview, Oregon. Revision 1

Contact Info

Product

Resources

About