Repeated Structural Imaging Reveals Nonlinear Progression of Experience-Dependent Volume Changes in Human Motor Cortex

Wenger, Elisabeth; Kühn, Simone; Verrel, Julius; Mårtensson, Johan; Bodammer, Nils; Lindenberger, Ulman; Lövdén, Martin

doi:10.1093/cercor/bhw141

Cited by 55 publications

(80 citation statements)

References 77 publications

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“…A recent longitudinal study on healthy individuals showed that structural neuroplasticity was inversely quadratic over time, and that motor-cortex plasticity occurred without any significant change in functional responsivity within the same brain region (Wenger et al, 2016). This finding indicates that functional and structural changes may not always be linear, and similarly to the present thesis, also stress the importance of using multimodal neuroimaging techniques to elucidate neuroplasticity.…”

Section: Amygdala Neuroplasticity Is Time-dependentsupporting

confidence: 80%

Hjärnan formas av psykologisk behandling

Månsson

2016

Linköping Studies in Behavioural Science

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Restructuring the socially anxious brain -using magnetic resonance imaging to advance our understanding of effective cognitive behaviour therapy for social anxiety disorder Printed by Linköping University Print Services (LiU-Tryck) in Linköping, Sweden, 2016 All previously published papers were reproduced with permission from the publishers ACKNOWLEDGEMENTAvhandlingen har genomförts i ett nära samarbete med forskare vid Uppsala universitet och Umeå Centre for Functional Brain Imaging (UFBI). Forskarskolan i klinisk psykiatri vid Karolinska Institutet tillhandhöll en bra forskarutbildning och PRIMA barn-och vuxenpsykiatri gav mig klinisk erfarenhet.Gerhard Andersson har utmanat och sporrat mig genom hela resan. Förutom färdigheter som forskare så kommer jag minnas när Gerhard gömt mina nycklar, häcklat Björn Afzelius-plattorna och burit iväg min cykel och annonserat att den "bortskänkes". Men Gerhards hyss överträffar knappats det brev som jag skickade med internposten för ett par år sedan. Tomas Furmark är en viktig del på min utvecklingskurva som forskare och när ni hör mig säga att "det finns ett par stenar till att vända på" eller att "man skulle ju vilja veta…" så förstår ni nu var det kommer från. Tomas är en av mina förebilder som forskare, men vi har också haft väldigt rolig under konferenserna och karaokekvällarna. C-J Boraxbekk fångade tidigt upp mitt intresse för forskning och det är tack vare C-Js inbjudan som jag fick möjligheten att pyssla med hjärnavbildningsforskning. Per Carlbring kom till Umeå som en vind och tog psykologstudenter med storm. Det hade inte blivit en randomiserad klinisk prövning utan Per. Jag har haft turen att få lära mig av fyra duktiga forskare från olika forskningskulturer och arbetssätt. Denna erfarenhet kommer forma mig som vetenskapsman. Jag har nu flera rollmodeller vars hantverk jag fått se på nära håll. Inte minst har jag haft väldigt kul. Från botten av mitt hjärta -tack Gerhard, Tomas, C-J och Per! Jag har haft ett stort nätverk av kollegor och kompisar som varit betydelsefulla och som jag vill berätta mer om. Andre F Marquand, Steven C R Williams, Alireza Salami, Owe Bodlund, Malin Gren Landell och Carl-Johan Uckelstam bidrog med klinisk kompetens och stöd vid analysarbete. I Umeå hade jag ett stort gäng studenter som hjälpte till vid experimenten, ingen nämnd ingen glömd. Blivande hjärnforskaren Hugo Hesser är inte bara en kul gubbe och en engagerad lärare som jag beundrar han tackade även ja till att vara granskare på mitt slutseminarium. Delar av mina arbeten granskades vid halvtid av Håkan Fischer, en hyvens person som också introducerat mig till ett gäng hyggliga sömnforskare. Helen MacDonald, a dear friend and a fellow EABCT board member, helped me with proof reading. Det var med alla dessa personers hjälp som jag kunde sätta pricken över i:et! Många har bidragit med kunskap genom att jag tagit del av deras forskning, lyssnat på deras presentationer eller att vi diskuterat kniviga frågor. Här vill jag passa på att tacka ett urval av dessa inspiratörer. För e...

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Section: Amygdala Neuroplasticity Is Time-dependentsupporting

confidence: 80%

Hjärnan formas av psykologisk behandling

Månsson

2016

Linköping Studies in Behavioural Science

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“…These graphs allow one to assign properties to a node, and, in the context of dynamic networks during learning, one could imagine assigning properties to brain regions including activity magnitudes [122], oscillatory information [123], grey matter volumes [124], and dopamine levels [12] that together would offer a more comprehensive picture of the neurophysiological processes accompanying learning. Tools are currently being developed to extend the network metrics described earlier for use in annotated graphs.…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

A Network Neuroscience of Human Learning: Potential to Inform Quantitative Theories of Brain and Behavior

Bassett

Mattar

2017

Trends in Cognitive Sciences

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Humans adapt their behavior to their external environment in a process often facilitated by learning. Efforts to describe learning empirically can be complemented by quantitative theories that map changes in neurophysiology to changes in behavior. In this review we highlight recent advances in network science that offer a sets of tools and a general perspective that may be particularly useful in understanding types of learning that are supported by distributed neural circuits. We describe recent applications of these tools to neuroimaging data that provide unique insights into adaptive neural processes, the attainment of knowledge, and the acquisition of new skills, forming a network neuroscience of human learning. While promising, the tools have yet to be linked to the well-formulated models of behavior that are commonly utilized in cognitive psychology. We argue that continued progress will require the explicit marriage of network approaches to neuroimaging data and quantitative models of behavior.

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“…A great deal of research has been devoted to unveiling the functional changes at the basis of such improvements (Krakauer et al, 2019). At the neural level, neuroimaging ( e.g., Wiestler and Diedrichsen, 2013; Wenger et al, 2017; Yokoi and Diedrichsen, 2019) and transcranial magnetic stimulation (TMS) studies ( e.g., Rosenkranz et al, 2007; Reis et al, 2008; Mawase et al, 2017) have shown that training is accompanied by a plastic reorganization of the motor cortex, potentially supporting the formation of new motor memories. Most noticeably, training was shown to amplify resting corticospinal (CS) excitability ( e.g., Christiansen et al, 2018) and to induce learning-specific changes of motor activity during movement execution (Krakauer et al, 2004; Steele and Penhune, 2010; Shmuelof et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Motor training strengthens corticospinal suppression during movement preparation

Vassiliadis

Derosière

Grandjean

et al. 2020

Preprint

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46Motor training improves the efficiency of trained movements and modifies neural activity 47 at rest and during motor execution. Training may also shape preparatory processes but the neural 48 correlates and the potential behavioral relevance of changes at the level of action preparation 49 remain unclear. In humans, transcranial magnetic stimulation (TMS) studies have shown that 50 movement preparation is accompanied by a suppression of corticospinal (CS) excitability relative 51 to a baseline measure; a phenomenon called preparatory suppression. Here, we trained participants 52 to initiate quick movements in an instructed-delay reaction time (RT) task and investigated resting 53 CS excitability as well as preparatory suppression over the practice blocks. We found that training 54 speeds up motor initiation, with no repercussion on error rates. Moreover, training increased 55 baseline CS excitability and deepened preparatory suppression. Importantly, training-related 56 changes in preparatory suppression were correlated to behavioral improvements: the subjects who 57 showed a stronger expansion of preparatory suppression were also those exhibiting larger gains in 58 RTs. Finally, in line with previous data, we observed a trial-by-trial relationship between the 59 amount of preparatory suppression and the subsequent RT: subjects responded faster on trials with 60 more preparatory suppression. Strikingly though, such a dependency of RTs on preparatory 61 suppression was tuned by the amount of training performed: while it was not evident early on, the 62 link emerged during the later practice blocks. Overall, our data indicate that training induces 63 changes in motor preparatory processes that are linked to an enhanced ability to initiate fast 64 movements. 65 66 67 3 Significance statement 68 69 Any movement is preceded by a period of preparation which involves significant changes 70 in the activity of the motor system, including a broad suppression of the corticospinal output 71 pathway, commonly referred to as preparatory suppression in human studies. Whether training can 72 alter such preparatory activity is unknown. Here, we show that motor training leads to a 73 strengthening of preparatory suppression in an instructed-delay reaction time (RT) task, and that 74 such change is related to a shortening of RTs. Moreover, at the single-trial level, we observed a 75 dependency of RTs on preparatory suppression which developed over training: the stronger the 76 preparatory suppression, the faster the RT. These results indicate that motor training can alter 77 motor preparatory activity in a behaviorally-relevant manner. 78 79 80 4 1. Introduction 81 82 Motor training generally improves the speed and/or accuracy at which movements are 83 selected, initiated and executed. A great deal of research has been devoted to unveiling the 84 functional changes at the basis of such improvements (Krakauer et al., 2019). At the neural level, 85 neuroimaging (e.g., Wiestler and Diedrichsen, 2013; Wenger et al., 2017; Yokoi and D...

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Repeated Structural Imaging Reveals Nonlinear Progression of Experience-Dependent Volume Changes in Human Motor Cortex

Cited by 55 publications

References 77 publications

Hjärnan formas av psykologisk behandling

Hjärnan formas av psykologisk behandling

A Network Neuroscience of Human Learning: Potential to Inform Quantitative Theories of Brain and Behavior

Motor training strengthens corticospinal suppression during movement preparation

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