Repeated social defeat stress inhibits development of hippocampus neurons through mitophagy and autophagy

Guo, Lanmin; Jiang, Ziyi; Sun, Run‐Cang; Pang, Wei Wei; Zhou, Xiao; Du, Meiling; Chen, Meng-Xiang; Lv, Xinyue; Wang, Jingtao

doi:10.1016/j.brainresbull.2022.01.009

Cited by 15 publications

(9 citation statements)

References 19 publications

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“…In another social defeat model, B6 mice were positioned in the cage of a larger and aggressive CD-1 mouse each day for 10 consecutive days (Guo et al, 2022). After each conflict, the B6 mouse spent the day in a cage with the aggressor separated by a transparent partition.…”

Section: Social Conflict/predator Stress Models and Mitochondrial Dys...mentioning

confidence: 99%

Mitochondrial dysfunction in animal models of PTSD: Relationships between behavioral models, neural regions, and cellular maladaptation

2023

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Post-traumatic stress disorder (PTSD) is a trauma-related condition that produces distressing fear memory intrusions, avoidance behaviors, hyperarousal, stress responses, insomnia and other symptoms. This review of rodent models of PTSD examines trauma effects on fear-related learning, cognition, and avoidance, emotional and arousal behaviors and on mitochondrial dysfunction in relevant neural pathways. The review focuses on research that includes four elements: consensus PTSD rodent models, behavioral phenotyping, mitochondrial dysfunction within key neural regions. This approach allows for the integration of behavioral, neural and cellular findings in PTSD models. The PTSD models reviewed include fear conditioning, predator/social stress, chronic restraint stress, single prolonged stress, social isolation, chronic unpredictable stress and early life stress. These models produce a variety of PTSD-related behaviors that include associative and non-associative fear- and stress-related responses, hyperarousal, avoidance behaviors, cognitive disturbances, social withdrawal, compulsive behaviors, anhedonia-, anxiety- and depression-related behaviors. Neural regions included fear- and stress-related regions of the prefrontal cortex, hippocampal, amygdala, nucleus accumbens and hypothalamus. PTSD models produced mitochondrial dysfunction that includes dysregulation of oxidative phosphorylation and other metabolic pathways including β-oxidation of fatty acids and the tricarboxylic acid pathway. These models generative neural reactive oxygen species that damage DNA, proteins, and lipids. Trauma models further altered mitochondrial stucture and replication and affected neuroinflammatory responses, signal transduction and apoptosis. Antidepressant medications used for the treatment of PTSD reversed stress-induced changes in some PTSD-like behaviors and many elements of brain mitochondrial dysfunction. Future studies can develop PTSD models which are ecologically valid and result in a broader manifestation of PTSD-related behaviors as it is clinically defined. This review highlights mitochondrial mechanisms associated with PTSD-like behaviors that have been produced in an array of consensus PTSD models and identifies putative circuit-based targets for more effective treatment for this debilitating disorder.

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Section: Social Conflict/predator Stress Models and Mitochondrial Dys...mentioning

confidence: 99%

Mitochondrial dysfunction in animal models of PTSD: Relationships between behavioral models, neural regions, and cellular maladaptation

2023

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“…138 140 Furthermore, excessive mitophagy inhibits the growth and development of hippocampal neurons, which affects information processing and transmission, and thus affects the regulation of emotions in the hippocampus. 141,142…”

Section: Gut Microbiotamentioning

confidence: 99%

Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms

Zhao,

Zhou,

Liu

et al. 2023

Anim Models and Exp Med

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Anxiety disorders have become one of the most severe psychiatric disorders, and the incidence is increasing every year. They impose an extraordinary personal and socioeconomic burden. Anxiety disorders are influenced by multiple complex and interacting genetic, psychological, social, and environmental factors, which contribute to disruption or imbalance in homeostasis and eventually cause pathologic anxiety. The selection of a suitable animal model is important for the exploration of disease etiology and pathophysiology, and the development of new drugs. Therefore, a more comprehensive understanding of the advantages and limitations of existing animal models of anxiety disorders is helpful to further study the underlying pathological mechanisms of the disease. This review summarizes animal models and the pathogenesis of anxiety disorders, and discusses the current research status to provide insights for further study of anxiety disorders.

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“…Recently, another particular form of autophagy, mitophagy, has also been found to play an important role in depression [ 18 , 115 ]. Mitophagy is a method for mitochondria to achieve self-control and renewal.…”

Section: The Role Of Nrf2 In Depressionmentioning

confidence: 99%

“…Mitophagy is a method for mitochondria to achieve self-control and renewal. By removing damaged or redundant mitochondria through autophagy, mitophagy maintained the stability of mitochondrial number and energy metabolism [ 115 ]. Damage of mitochondrial DNA (mtDNA) has been reported in patients with MDD [ 18 ].…”

Section: The Role Of Nrf2 In Depressionmentioning

confidence: 99%

Nrf2: An all-rounder in depression

et al. 2022

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Repeated social defeat stress inhibits development of hippocampus neurons through mitophagy and autophagy

Cited by 15 publications

References 19 publications

Mitochondrial dysfunction in animal models of PTSD: Relationships between behavioral models, neural regions, and cellular maladaptation

Mitochondrial dysfunction in animal models of PTSD: Relationships between behavioral models, neural regions, and cellular maladaptation

Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms

Nrf2: An all-rounder in depression

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