Repeated Serum Lipid Measurements During the Peri-Hospitalization Period

Nawaz, Haq; Comerford, Beth; Njike, Valentine Yanchou; Dhond, Abhay J.; Plavec, Martin; Katz, David L.

doi:10.1016/j.amjcard.2006.06.030

Cited by 14 publications

(10 citation statements)

References 13 publications

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“…This suggests that the small dip in LDL-C was associated with the day after admission (Day 2 of hospitalization), rather than with the time after onset of ACS symptoms. This observation is similar to the slight decrease in LDL-C levels from admission to Day 3 found in patients hospitalized for a variety of complaints, including infectious, respiratory, and gastrointestinal diseases (13). Therefore, the decrease in LDL-C concentration on Day 2 of hospitalization may reflect causes related to hospitalization, such as altered oral intake or intravenous hydration.…”

Section: Discussionsupporting

confidence: 65%

Lipid Levels After Acute Coronary Syndromes

Pitt

Loscalzo

Ycas

et al. 2008

Journal of the American College of Cardiology

141

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Section: Discussionsupporting

confidence: 65%

Lipid Levels After Acute Coronary Syndromes

Pitt

Loscalzo

Ycas

et al. 2008

Journal of the American College of Cardiology

141

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“…Also, there is a controversy on assessing serum lipid levels during hospitalization, due to the wide range of variability noted with the in-hospital and 1-2 months post-discharge lipoprotein measurement [13-15]. It is postulated that in acute coronary syndrome, serum triglycerides act as acute phase reactants and its variability with fasting states alters the assessment of serum lipoprotein measurements [16].…”

Section: Discussionmentioning

confidence: 99%

Serum lipoprotein levels in takotsubo cardiomyopathy vs. myocardial infarction

Gaddam¹,

Nimmagadda²,

Nagrani³

et al. 2011

Int Arch Med

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BackgroundIn the setting of myocardial infarction (MI) or acute coronary syndrome (ACS), current guidelines recommend early and aggressive lipid lowering therapy with statins, irrespective of the baseline lipoprotein levels. Takotsubo cardiomyopathy (TCM) patients have a clinical presentation similar to myocardial infarction and thus receive early and aggressive statin therapy during their initial hospitalization. However, the pathology of TCM is not atherosclerotic coronary artery disease and hence we assumed the lipid profiles in TCM would be healthier than coronary artery disease patients.MethodsIn this retrospective study, we assessed fasting serum lipoprotein levels of ten TCM patients and compared them with forty, age and sex-matched myocardial infarction (MI) patients.ResultsComparing serum lipoprotein levels of TCM with MI group, there was no significant difference in mean total cholesterol between the two groups (174.5 mg/dL vs. 197.6 mg/dL, p = 0.12). However, in the TCM group, mean HDL-C was significantly higher (66.87 mg/dL vs. 36.5 mg/dL, p = 0.008), the mean LDL-C was significantly lower (89.7 mg/dL vs. 128.9 mg/dL, p = 0.0002), and mean triglycerides was also significantly lower (65.2 mg/dL vs. 166.8 mg/dL, p < 0.0001).ConclusionsIn this study, TCM patients in comparison to MI patients had significantly higher levels of HDL-C, lower levels of LDL-C levels and triglycerides. The lipid profiles in TCM were consistent with the underlying pathology of non-atherosclerotic, non-obstructive coronary artery disease. As lipoproteins in most TCM patients were within the optimal range, we recommend an individual assessment of lipid profiles along with their coronary heart disease risk factors for considering long term lipid-lowering therapy. A finding of hyperalphalipoproteinemia or hypotriglyceridemia in 40% of TCM patients is novel but this association needs to be confirmed in future studies with larger sample sizes. These findings may provide clues in understanding the pathogenesis of takotsubo cardiomyopathy.

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“…Comparisons of the high prevalence of low HDL cholesterol to other young ACS cohort studies are not valid because of the known reductions in lipid measurements after 24 h of AMI. While the use of specific components of the lipid panel to assess CV risk is limited, the total cholesterol/HDL cholesterol ratio is a stable lipid parameter between acute illness and subsequent recovery of various illnesses (Nawaz et al, 2006). The ratio also remains constant between lipid panels obtained within 24 h of an AMI and 4 days post‐AMI (Wattanasuwan et al, 2001).…”

Section: Discussionmentioning

confidence: 99%