Repeated sauna therapy improves myocardial perfusion in patients with chronically occluded coronary artery-related ischemia

Sobajima, Mitsuo; Nozawa, Takashi; Ihori, Hiroyuki; Shida, Takuya; Ohori, Takashi; Suzuki, Takayuki; Matsuki, Akira; Yasumura, Satoshi; Inoue, Hiroshi

doi:10.1016/j.ijcard.2011.12.064

Cited by 50 publications

(35 citation statements)

References 32 publications

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“…Several studies have reported the effects of repeated sauna therapy in patients with CHF [3,4,7,15,16]. The majority of these studies have examined the effects of adding repeated sauna therapy to conventional therapies such as physical therapy or pharmaceutical therapy in patients with CHF.…”

Section: Introductionmentioning

confidence: 99%

Combined effects of repeated sauna therapy and exercise training on cardiac function and physical activity in patients with chronic heart failure

Haseba

Sakakima²,

Kubozono

et al. 2015

Disability and Rehabilitation

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The addition of exercise training programs to repeated sauna therapy may be efficient and effective for improvement of cardiac function and daily activities for patients with chronic heart failure. IMPLICATIONS OF REHABILITATION: Repeated sauna therapy is an effective means of improving cardiac, vascular function and mental health in CHF patients. Exercise training is an effective means of improving exercise capacity, thus improving ADL. Combination of repeated sauna therapy and exercise training may be recommended as a comprehensive treatment to improve cardiac function, ambulation capacity, and ADL in CHF patients.

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Section: Introductionmentioning

confidence: 99%

Combined effects of repeated sauna therapy and exercise training on cardiac function and physical activity in patients with chronic heart failure

Haseba

Sakakima²,

Kubozono

et al. 2015

Disability and Rehabilitation

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“…FIR therapy has been shown to improve the health of patients with chronic diseases, in particular, vessel-related disorders 16 . The evidence shows that FIR treatment increased peripheral blood circulation 17 and artery blood flow 18,19 and thereby has been applied to improve access blood flow in hemodialysis patients [20][21][22][23] . FIR also has the potential for treatment of angiogenesis-related diseases include the improvement of ECs functions 24,25 , protection of ECs from high glucose-induced injury 26 , inhibition of EC inflammation 27 , and promotion of angiogenesis by ECs 28 .…”

mentioning

confidence: 99%

miR-548aq-3p is a novel target of Far infrared radiation which predicts coronary artery disease endothelial colony forming cell responsiveness

Tsai

Chiang²,

et al. 2020

Sci Rep

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Non-invasive far infrared radiation (FIR) has been observed to improve the health of patients with coronary artery disease (CAD). Endothelial colony forming cells (ECFCs) contribute to vascular repair and CAD. The goal of this study was to uncover the role of FIR in ECFCs function and to reveal potential biomarkers for indication of FIR therapy in CAD patients. FIR significantly enhanced in vitro migration (transwell assay) and tube formation (tube length) capacities in a subpopulation of CAD ECFCs. Clinical parameters associated with the responsiveness of ECFCs to FIR include smoking and gender. ECFCs from CAD patients that smoke did not respond to FIR in most cases. In contrast, ECFCs from females showed a higher responsiveness to FIR than ECFCs from males. To decipher the molecular mechanisms by which FIR modulates ECFCs functions, regardless of sex, RNA sequencing analysis was performed in both genders of FIR-responsive and FIR-non/unresponsive ECFCs. Gene Ontology (GO) analysis of FIR up-regulated genes indicated that the pathways enriched in FIR-responsive ECFCs were involved in cell viability, angiogenesis and transcription. Small RNA sequencing illustrated 18 and 14 miRNAs that are up-and down-regulated, respectively, in FIR-responsive CAD ECFCs in both genders. Among the top 5 up-and down-regulated miRNAs, down-regulation of miR-548aq-3p in CAD ECFCs after FIR treatment was observed in FIR-responsive CAD ECFCs by RT-qPCR. Down-regulation of miR-548aq-3p was correlated with the tube formation activity of CAD ECFCs enhanced by FIR. After establishment of the down-regulation of miR-548aq-3p by FIR in CAD ECFCs, we demonstrated through overexpression and knockdown experiments that miR-548aq-3p contributes to the inhibition of the tube formation of ECFCs. This study suggests the down-regulation of miR-548aq-3p by FIR may contribute to the improvement of ECFCs function, and represents a novel biomarker for therapeutic usage of FIR in CAD patients.open Scientific RepoRtS | (2020) 10:6805 | https://doi.org/10.1038/s41598-020-63311-1 www.nature.com/scientificreports www.nature.com/scientificreports/ progenitor cells (EPCs). The classification of EPC has been applied to multiple cell types, including endothelial colony forming cells (ECFCs) 2 . ECFCs exhibit the ability to form colonies after prolonged culture and proliferate after re-plating in an in vitro culture system. These cells are identified as positive for VE-cadherin, VEGFR2 (vascular endothelial growth factor receptor 2), VEGFR1, CD31, CD105, CD146, VWF (von Willebrand factor), CD34, and negative for CD14, CD45, CD115, CD133 3 . ECFCs have the potential to incorporate into the endothelial layer and differentiate into mature ECs, thereby contributing to repair of injured vascular endothelium as well as forming new blood vessels 4 . ECFCs can further enhance vasculogenic properties by releasing trophic factors 5 . With these capacities, ECFCs have been suggested to function in maintaining vascular homeostasis and preventing CAD. In line with this, increas...

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“…Darunter verbesserte sich die Blutgefäßneubildung am Herzen, wobei als Ursache eine gesteigerte Stickoxid-Produktion in den Blutgefäßwänden genannt wurde. 2013 berichteten die gleichen Autoren [29] Erfolge bei einer Behandlung von Patienten mit einer koronaren Herzerkrankung in einer Niedrigtemperatur-Infrarot-Kabine. 16 Patienten gingen täglich für 15 min in die Wärmekabine (60 °C Lufttemperatur) und ruhten anschließend für 30 min nach.…”

Section: Sauna Zur Vorbeugung Und Behandlung Von Herz-kreislauf-erkraunclassified

Das Potenzial der Sauna im Rahmen der Prävention - eine Übersicht neuerer Erkenntnisse

Brenke¹

2015

Complement Med Res

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Die Möglichkeiten der Sauna im Rahmen von Präventionsmaßnahmen aber auch der Therapie werden bei Weitem nicht ausgeschöpft. In diesem Beitrag werden neuere Erkenntnisse vorgestellt, die das präventive und therapeutische Potenzial von Sauna bei einer Reihe von Zivilisationserkrankungen aufzeigen. Als Beispiele seien die Abhärtung gegen grippale Infekte und Herz-Kreislauf-Erkrankungen genannt sowie der Einsatz im Rahmen von Schmerztherapie z.B. bei der Fibromyalgie. Sauna ist aber auch eine empfehlenswerte Intervention zur Stressprophylaxe und bei Stoffwechselerkrankungen wie dem Diabetes Typ 2.

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Repeated sauna therapy improves myocardial perfusion in patients with chronically occluded coronary artery-related ischemia

Cited by 50 publications

References 32 publications

Combined effects of repeated sauna therapy and exercise training on cardiac function and physical activity in patients with chronic heart failure

Combined effects of repeated sauna therapy and exercise training on cardiac function and physical activity in patients with chronic heart failure

miR-548aq-3p is a novel target of Far infrared radiation which predicts coronary artery disease endothelial colony forming cell responsiveness

Das Potenzial der Sauna im Rahmen der Prävention - eine Übersicht neuerer Erkenntnisse

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