Repeated pre-exposure to morphine into the ventral pallidum enhances morphine-induced place preference: Involvement of dopaminergic and opioidergic mechanisms

Zarrindast, Mohammad‐Reza; Ebrahimi-Ghiri, Mohaddeseh; Rostami, Parastoo; Rezayof, Ameneh

doi:10.1016/j.bbr.2007.03.019

Cited by 28 publications

(13 citation statements)

References 56 publications

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“…This finding indicated that a single dose of morphine is sufficient to induce long-term behavioral sensitization in an invertebrate system. The induction of behavioral sensitization with a single dose of morphine had previously been observed in mammals (Smith, 1985, 1991; Zarrindast et al, 2007) and such motivational similarities appear to extend to invertebrates (Panksepp and Burgdorf, 2000; Poerzgen et al, 2001). Although sensitization (or reverse tolerance) is progressively enhanced, sensitization is not only a direct pharmacological action of the drug, but also of learned associations with drug experience (Pierce and Kalivas, 1997).…”

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confidence: 57%

“…For instance, repeated drug exposure, separated by long intervals, is thought to be more effective in inducing sensitization than a chronic regime of high or escalating doses at short intervals (Vanderschueren and Kalivas, 2000; Vanderschueren et al, 1997; Robinson and Becker, 1986). Repeated, intermittent, or chronic exposure to amphetamine, cocaine, and morphine causes long-lasting behavioral sensitization in rats (Vanderschueren et al, 1999; Pierce and Kalivas, 1997; Zarrindast et al, 2007; White, 1995). Opioids in mammals either reduce or enhance locomotor activity, depending on dose and time protocols (Timára et al, 2005; Zhao et al, 2004).…”

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confidence: 99%

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Drug-sensitive reward in crayfish: An invertebrate model system for the study of SEEKING, reward, addiction, and withdrawal

Huber

Panksepp

Nathaniel

et al. 2011

Neuroscience & Biobehavioral Reviews

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In mammals, rewarding properties of drugs depend on their capacity to activate appetitive motivational states. With the underlying mechanisms strongly conserved in evolution, invertebrates have recently emerged as a powerful new model in addiction research. In crayfish natural reward has proven surprisingly sensitive to human drugs of abuse, opening an unlikely avenue of research into the basic biological mechanisms of drug addiction. In a series of studies we first examined the presence of natural reward systems in crayfish, then characterized its sensitivity to a wide range of human drugs of abuse. A conditioned place preference (CPP) paradigm was used to demonstrate that crayfish seek out those environments that had previously been paired with the psychostimulants cocaine and amphetamine, and the opioid morphine. The administration of amphetamine exerted its effects at a number of sites, including the stimulation of circuits for active exploratory behaviors (i.e., SEEKING). A further study examined morphineinduced reward, extinction and reinstatement in crayfish. Repeated intra-circulatory infusions of morphine served as a reward when paired with distinct visual or tactile cues. Morphine-induced CPP was extinguished after repeated saline injections. Following this extinction phase, morphineexperienced crayfish were once again challenged with the drug. The priming injections of morphine reinstated CPP at all tested doses, suggesting that morphine-induced CPP is unrelenting. In an exploration of drug-associated behavioral sensitization in crayfish we concurrently mapped measures of locomotion and rewarding properties of morphine. Single and repeated intra-✩ Studies reported in this paper were supported by a grant to R.H. and J.P. (NIH/NIDA 1R21DA016435-01A1) and by the help of Hope for Depression Research Foundation to J.P.

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confidence: 57%

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confidence: 99%

Drug-sensitive reward in crayfish: An invertebrate model system for the study of SEEKING, reward, addiction, and withdrawal

Huber

Panksepp

Nathaniel

et al. 2011

Neuroscience & Biobehavioral Reviews

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“…Repeated intrapallidal morphine injections facilitated a CPP induced by a low dose of systemic morphine. Peripheral pretreatment with the opioid receptor antagonist naloxone or dopaminergic antagonists suppressed the CPP, indicating that the facilitatory effects of intra-VP morphine involve activation of mu and dopaminergic receptors (424). …”

Section: Local Pharmacological Manipulation Of the Opioid Systemmentioning

confidence: 99%

Reward Processing by the Opioid System in the Brain

Merrer¹,

Becker²,

Befort³

et al. 2009

Physiological Reviews

803

676

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The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides processed from three protein precursors, proopiomelanocortin, proenkephalin, and prodynorphin. Opioid receptors are recruited in response to natural rewarding stimuli and drugs of abuse, and both endogenous opioids and their receptors are modified as addiction develops. Mechanisms whereby aberrant activation and modifications of the opioid system contribute to drug craving and relapse remain to be clarified. This review summarizes our present knowledge on brain sites where the endogenous opioid system controls hedonic responses and is modified in response to drugs of abuse in the rodent brain. We review 1) the latest data on the anatomy of the opioid system, 2) the consequences of local intracerebral pharmacological manipulation of the opioid system on reinforced behaviors, 3) the consequences of gene knockout on reinforced behaviors and drug dependence, and 4) the consequences of chronic exposure to drugs of abuse on expression levels of opioid system genes. Future studies will establish key molecular actors of the system and neural sites where opioid peptides and receptors contribute to the onset of addictive disorders. Combined with data from human and nonhuman primate (not reviewed here), research in this extremely active field has implications both for our understanding of the biology of addiction and for therapeutic interventions to treat the disorder.

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“…Furthermore, vehicle treatments (saline or artificial cerebrospinal fluid) injected into VP even as slow as 0.1 μl/min for a total volume of only 0.25 μg are sufficient to produce a persistent deficits in radial arm maze performance (Chrobak and Napier, 2002). While motor (e.g., Johnson and Napier, 2000; Skoubis and Maidment, 2003) and place conditioning behaviors (e.g., Nikolaus et al, 1999; Skoubis and Maidment, 2003; Zarrindast et al, 2007) are not altered by intra-VP injections of a variety of treatment vehicles, the observation that radial arm maze performance deficits can occur suggests that at least some VP neurons are sensitive to fluid perturbation and/or that some behavioral readouts are more sensitive to such perturbations.…”

Section: 0 Vp Influences On Behaviormentioning

confidence: 99%

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

Root

Meléndez

Záborszky

et al. 2015

Progress in Neurobiology

284

362

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The ventral pallidum (VP) plays a critical role in the processing and execution of motivated behaviors. Yet this brain region is often overlooked in published discussions of the neurobiology of mental health (e.g., addiction, depression). This contributes to a gap in understanding the neurobiological mechanisms of psychiatric disorders. This review is presented to help bridge the gap by providing a resource for current knowledge of VP anatomy, projection patterns and subregional circuits, and how this organization relates to the function of VP neurons and ultimately behavior. For example, ventromedial (VPvm) and dorsolateral (VPdl) VP subregions receive projections from nucleus accumbens shell and core, respectively. Inhibitory GABAergic neurons of the VPvm project to mediodorsal thalamus, lateral hypothalamus, and ventral tegmental area, and this VP subregion helps discriminate the appropriate conditions to acquire natural rewards or drugs of abuse, consume preferred foods, and perform working memory tasks. GABAergic neurons of the VPdl project to subthalamic nucleus and substantia nigra pars reticulata, and this VP subregion is modulated by, and is necessary for, drug-seeking behavior. Additional circuits arise from nonGABAergic neuronal phenotypes that are likely to excite rather than inhibit their targets. These subregional and neuronal phenotypic circuits place the VP in a unique position to process motivationally-relevant stimuli and coherent adaptive behaviors.

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Repeated pre-exposure to morphine into the ventral pallidum enhances morphine-induced place preference: Involvement of dopaminergic and opioidergic mechanisms

Cited by 28 publications

References 56 publications

Drug-sensitive reward in crayfish: An invertebrate model system for the study of SEEKING, reward, addiction, and withdrawal

Drug-sensitive reward in crayfish: An invertebrate model system for the study of SEEKING, reward, addiction, and withdrawal

Reward Processing by the Opioid System in the Brain

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

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