Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model

Kim, Yoon Seob; Jeong, Kwan; Kim, Jung Eun; Woo, Young Sup; Kim, Beom Joon; Kang, Hoon

doi:10.5021/ad.2016.28.5.586

Cited by 69 publications

(83 citation statements)

References 22 publications

(27 reference statements)

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“…'s Murine model study of microneedling, hair growth varied based on the size of the needle and the number of times the skin was rolled over. Mice demonstrated greatest hair growth with both 0.25‐mm needles and 0.5‐mm needles rolled over the skin in a back‐and‐forth movement 10 times (0.15‐, 0.25‐, 0.5‐ and 1‐mm needles were all tested) . To derive greatest therapeutic success in human subjects, a standard optimal protocol needs to be determined.…”

Section: Microneedling Procedures For Alopeciamentioning

confidence: 99%

Microneedling for the treatment of hair loss?

Fertig

Gamret

Cervantes

et al. 2017

Acad Dermatol Venereol

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Microneedling is a minimally invasive dermatological procedure in which fine needles are rolled over the skin to puncture the stratum corneum. This therapy is used to induce collagen formation, neovascularization and growth factor production of treated areas. It has been used in a wide range of dermatologic conditions, including androgenetic alopecia (AGA) and alopecia areata, among others. While there are a limited number of studies examining this therapy in the use of hair loss, microneedling has been successfully paired with other hair growth promoting therapies, such as minoxidil, platelet-rich plasma and topical steroids, and shown to stimulate hair follicle growth. It is thought that microneedling facilitates penetration of such first-line medications, and this is one mechanism by which it promotes hair growth. To date, the area most studied and with the most success has been microneedling treatment of AGA. While the current evidence does not allow one to conclude superiority of microneedling over existing standard therapies for hair loss, microneedling shows some promise in improving hair growth, especially in combination with existing techniques. This review summarizes the current literature regarding microneedling in the treatment of alopecia and calls for further studies to define a standard treatment protocol.

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Section: Microneedling Procedures For Alopeciamentioning

confidence: 99%

Microneedling for the treatment of hair loss?

Fertig

Gamret

Cervantes

et al. 2017

Acad Dermatol Venereol

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“…Minoxidil and finasteride has been used as treatment of these conditions since long. Microneedling for AA is a new addition to the therapeutic armamentarium for AA [1][2][3][4]. Microneedling is minimally invasive procedure in which a roller with fine needles is rolled over the skin.…”

Section: Introductionmentioning

confidence: 99%

Microneedling for androgenetic alopecia not responding to conventional treatment

Parajuli¹,

Paudel²

2020

Our Dermatol Online

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Microneedling appears to be appealing treatment of androgenetic alopecia (AA). We report five cases of androgenetic alopecia that were treated with microneedling along with oral finasteride and minoxidil, as a first case series from Nepal. Most of them showed moderate to greatly increase in hair growth with satisfaction score of more than 75% without any complications. This case series highlights the importance of considering microneedling as one of the treatment choice for hair growth in patients with AA.

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“…In humans, mice and dogs, the creation of superficial microtrauma via a microneedling (MN) device has been shown to induce mechanical stimulation of the hair follicle resulting in permanent hair regrowth . Human studies also have reportedd that application of platelet‐rich plasma (PRP) in conjunction with MN results in more rapid hair regrowth with better quality hairs than MN alone …”

Section: Introductionmentioning

confidence: 99%

“…The microtrauma is also thought to activate stem cells in the hair bulge area resulting in overexpression of hair growth related genes, namely: fibroblast growth factor ( FGF ), vascular endothelial growth factor ( VEGF ), Wnt and B catenin . It is believed that these genes stimulate the development of new follicles and promote neovascularization . Because the microchannels are only briefly open, the risk of infection is negligible, and the only adverse reaction reported is short‐term erythema …”

Section: Introductionmentioning

confidence: 99%

A small scale study to evaluate the efficacy of microneedling in the presence or absence of platelet‐rich plasma in the treatment of post‐clipping alopecia in dogs

Diamond¹,

Schick²,

Savage³

et al. 2019

Veterinary Dermatology

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Background -Post-clipping alopecia often has a clinically poor response to therapy and prolonged alopecia is a source of anxiety for some owners. In humans and dogs, superficial microtrauma via a microneedling (MN) device induces mechanical stimulation of the hair follicle with resultant hair regrowth. Human studies suggest that concurrent application of platelet-rich plasma (PRP) with MN induces more rapid regrowth of better-quality hair than microneedling alone.Hypothesis -Microneedling with PRP will induce more rapid regrowth of better quality hair.Animals -Four unrelated client-owned dogs diagnosed with post-clipping alopecia.Methods and Materials -This was a prospective study. The affected site was divided in half, with the first half treated with MN alone and the second half treated with MN + PRP. Hair regrowth was assessed by clinician and owner using a hair growth assessment scale (HGAS) at one, three, six and 12 months.Results -At three months, all dogs had improved and three exhibited greater hair regrowth on the MN + PRP side. A similar response was noted bilaterally in three dogs, which had improved by 76-100% at six months and remained unchanged at 12 months. One dog improved by < 26% at six months, but had> 50% re-growth by 12 months. The small sample size precluded statistical analysis.Conclusions and clinical importance -In dogs with post-clipping alopecia, MN + PRP appeared to induce more rapid hair regrowth than MN; however, overall results were visibly equivalent by six months regardless of method. Both MN and MN + PRP proved successful for treating post-clipping alopecia.

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Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model

Cited by 69 publications

References 22 publications

Microneedling for the treatment of hair loss?

Microneedling for the treatment of hair loss?

Microneedling for androgenetic alopecia not responding to conventional treatment

A small scale study to evaluate the efficacy of microneedling in the presence or absence of platelet‐rich plasma in the treatment of post‐clipping alopecia in dogs

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