2020
DOI: 10.1002/alz.038143
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Repeated memory‐based assessments: Implications for clinical trials and practice

Abstract: Background Detailed longitudinal neuropsychological assessment in the Harvard Aging Brain Study (HABS) and related studies has revealed that subtle decrements in associative and semantic memory, as well as reduced practice effects for repeated items may be the earliest cognitive changes in preclinical AD. Utilizing digital, repeated, and remote assessment of these cognitive functions has the potential to increase the rapidity and ease with which these subtle changes can be detected. We previously showed that d… Show more

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Cited by 2 publications
(3 citation statements)
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“…BRANCH primarily consists of measures of associative memory, pattern separation, and semantically facilitated learning and recall. BRANCH also uses paradigms and stimuli relevant to everyday cognitive tasks 79 …”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…BRANCH primarily consists of measures of associative memory, pattern separation, and semantically facilitated learning and recall. BRANCH also uses paradigms and stimuli relevant to everyday cognitive tasks 79 …”
Section: Resultsmentioning
confidence: 99%
“…BRANCH also uses paradigms and stimuli relevant to everyday cognitive tasks. 79 In a similar vein, the Online Repeatable Cognitive Assessment-Language Learning Test (ORCA-LLT) developed by Dr. Lim at Monash University in Australia, asks participants to learn the English word equivalents of 50 Chinese characters for 25 minutes daily over 6 days.…”
Section: Using Mobile and Serial Assessment To Identify Subtle Decrem...mentioning
confidence: 99%
“…HABS has also developed the Boston Remote Assessment for Neurocognitive Health (BRANCH), which combines two paired associative learning tasks, an associated memory test, and a continuous visual recognition task accessible on a smartphone. In a recent study, BRANCH was shown to be correlated with scores on the paper-based preclinical Alzheimer’s cognitive composite (PACC5) ( 20 ).…”
Section: Implementing Digital Devices In Ad Clinical Studiesmentioning
confidence: 99%