Repeated measurements of aldicarb in blood and urine in a case of nonfatal poisoning

Abstract

<jats:p> A nonfatal case of poisoning involving aldicarb, an extremely toxic carbamate pesticide, is presented. A 39-year-old female ingested an unknown amount of aldicarb, together with alprazolam and sertraline. On admission to ICU (T<jats:sub>0</jats:sub>), she displayed marked cholinergic symptoms and a deep coma. The patient was given pralidoxime and atropine. Her condition gradually improved on days 2 and 3 and she was discharged at T<jats:sub>0</jats:sub>+80 h. Aldicarb was assayed by high-performance liquid chromatography on 21 blood and 8 urine samples successively taken during hospitalization. At the same time, serum pseudocholinesterase activity was followed on 21 successive samples. Blood aldicarb level was 3.11 g/mL at T<jats:sub>0</jats:sub> and peaked at T<jats:sub>0</jats:sub>+3.5 h (3.22 g/mL), then followed a two-slope decay with a terminal half-life of ca. 20 h. Aldicarb was detected in all urine samples (peak level: 6.95 g/mL at T<jats:sub>0</jats:sub>+31.5 h) and was still present at the time of discharge. Serum pseudo-cholinesterase activity remained low (10% of normal) until the 30th hour then rapidly increased and returned to normal after the 60th hour. The patient’s clinical picture closely followed blood aldicarb levels and serum pseudo-cholinesterase activities. To our knowledge, this is the first report of an aldicarb poisoning documented by repeated measurements of the drug in the intoxicated person. Human &amp; Experimental Toxicology (2001) 20, 657–660. </jats:p>

Aldicarb poisoning: one case report

“…A few cases of aldicarb poisoning have been described, eight nonlethal [5][6][7][8][9][10][11][12] and one reporting a fatal intoxication case [13].…”

Toxicologia do praguicida aldicarb ("chumbinho"): aspectos gerais, clínicos e terapêuticos em cães e gatos

“…Aldicarb: propriedades químicas, toxicocinética e toxicodinâmica O aldicarb ou 2-metil-2(metiltio)-propionaldeído O-(metilcarbamoil) oxima, um metilcarbamato, foi introduzido na agricultura na década de 60 com o objetivo de controlar uma ampla variedade de insetos, ácaros e nematódeos (TRACQUI et al, 2001). No Brasil, ele é manufaturado na forma de pequenos grânulos pretos, com 15% de princípio ativo (Temik 150 ® ), e é popularmente conhecido como "chumbinho".…”

“…A elevada lipofilicidade deste composto resulta em toxicidade dérmica aproximadamente mil vezes maior que a dos outros carbamatos, podendo ser absorvido rapidamente pela pele íntegra, se na forma líquida (TRACQUI et al, 2001).…”

Difficultés analytiques de la caractérisation des pesticides dans le sang

“…[17] ont développé en 2001 une technique de dosage de l'aldicarbe par HPLC et détection UV par barrettes de diodes. Brièvement 3 mL de sang sont extraits par le chloroforme en milieu tampon phosphate à pH 5,5 en pré-sence de l'étalon interne (carbofuran).…”