Repeated leftover serosurvey of SARS-CoV-2 IgG antibodies, Greece, March and April 2020

Bogogiannidou, Zacharoula; Vontas, Alexandros; Dadouli, Katerina; Kyritsi, Maria; Soteriades, Soteris; Nikoulis, Dimitrios J.; Mouchtouri, Varvara A.; Koureas, Michalis; Kazakos, Evangelos; Spanos, Emmanouil; Gioula, Georgia; Ntzani, Evangelia; Eleftheriou, Alexandros A.; Vatopoulos, Alkiviadis; Petinaki, Efthimia; Papaevangelou, Vassiliki; Speletas, Matthaios; Tsiodras, Sotirios; Hadjichristodoulou, Christos

doi:10.2807/1560-7917.es.2020.25.31.2001369

Cited by 59 publications

(71 citation statements)

References 6 publications

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“…In our preliminary results, the weighted overall seroprevalence of Igs against SARS-CoV-2 was 0.93% (95% CI: 0.27, 2.09) among 2500 donors from the NKUA sampled in June-July 2020. Our estimate is similar to the seroprevalence (0.85%) of Igs against SARS-CoV-2 found in large urban areas in Greece in a leftover IgG serosurvey using samples tested during March and April 2020 [9]. We also showed that seroprevalence varied between gender (higher in males), age groups (higher in the 55-74 years age group) and position at the NKUA (higher in faculty members/laboratory assistants), although the differences recorded were not statistically significant.…”

Section: Discussionsupporting

confidence: 86%

“…As of now, serological surveys reported that viral spread ranges from <1.0% in countries less affected by the pandemic (e.g., Germany, Greece, Norway, Iceland) to higher levels in countries that did not implement early public health measures (5.5% in Spain, 6.0% in Belgium, 8.5% in the UK). In some heavily affected areas in Italy, Brazil and some states in the USA, seroprevalence was found to be as high as 25% [9][10][11][12][13][14][15]. Nevertheless, it was reportedly suggested that SARS-CoV-2 infections are potentially underdiagnosed and asymptomatic cases account for up to 41% [3] and in specific populations up to 59% [16] of infections.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the early nationwide lock-down and additional public health measures, Greece was among the European countries less affected by the SARS-CoV-2 pandemic, with nearly 8000 confirmed cases and 238 deaths [1]. As of April 2020, the estimated prevalence of anti-SARS-CoV-2 Igs in the general population was 0.23% [9], although higher percentages were sporadically recorded in overpopulated or SARS-CoV-2-exposed niches, due to differences in infection rates [10].…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Antibodies against SARS-CoV-2 among the Personnel and Students of the National and Kapodistrian University of Athens, Greece: A Preliminary Report

Tsitsilonis

Paraskevis²,

Lianidou³

et al. 2020

Life

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Due to early implementation of public health measures, Greece had low number of SARS-CoV-2 infections and COVID-19 severe incidents in hospitalized patients. The National and Kapodistrian University of Athens (ΝΚUA), especially its health-care/medical personnel, has been actively involved in the first line of state responses to COVID-19. To estimate the prevalence of antibodies (Igs) against SARS-CoV-2 among NKUA members, we designed a five consecutive monthly serosurvey among randomly selected NKUA consenting volunteers. Here, we present the results from the first 2500 plasma samples collected during June–July 2020. Twenty-five donors were tested positive for anti-SARS-CoV-2 Igs; thus, the overall seroprevalence was 1.00%. The weighted overall seroprevalence was 0.93% (95% CI: 0.27, 2.09) and varied between males [1.05% (95% CI: 0.18, 2.92)] and females [0.84% (95% CI: 0.13, 2.49)], age-groups and different categories (higher in participants from the School of Health Sciences and in scientific affiliates/faculty members/laboratory assistants), but no statistical differences were detected. Although focused on the specific population of NKUA members, our study shows that the prevalence of anti-SARS-CoV-2 Igs for the period June–July 2020 remained low and provides knowledge of public health importance for the NKUA members. Given that approximately one in three infections was asymptomatic, continuous monitoring of the progression of the pandemic by assessing Ig seroprevalence is needed.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Antibodies against SARS-CoV-2 among the Personnel and Students of the National and Kapodistrian University of Athens, Greece: A Preliminary Report

Tsitsilonis

Paraskevis²,

Lianidou³

et al. 2020

Life

View full text Add to dashboard Cite

show abstract

“…Population-based and community-based studies in USA showed a great variability in seroprevalence of SARS-CoV-2 antibodies from 1.1% to 14.4% [ [63] , [64] , [65] , [66] , [67] ]. Similar studies in Europe [ [68] , [69] , [70] ] and China [ 71 ] found very different seroprevalence in the general population ranging from 0.23% to 10.9%. These differences in seroprevalence among studies may be attributable to several reasons, e.g.…”

Section: Discussionsupporting

confidence: 67%

Seroprevalence of SARS-CoV-2 antibodies and associated factors in healthcare workers: a systematic review and meta-analysis

Galanis

Vraka

Fragkou

et al. 2021

Journal of Hospital Infection

288

308

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Background Health care workers (HCWs) represent a high risk population for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Aim To determine the seroprevalence of SARS-CoV-2 antibodies among HCWs, and to find out the factors that are associated with this seroprevalence. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were applied for this systematic review and meta-analysis. Databases including PubMed/MEDLINE and pre-print services (medRχiv and bioRχiv) were searched from inception up to August 24, 2020. Findings Forty-nine studies, including 127,480 HCWs met the inclusion criteria. The estimated overall seroprevalence of SARS-CoV-2 antibodies among HCWs was 8.7% (95% CI: 6.7-10.9%). Seroprevalence was higher in studies that were conducted in North America (12.7%) compared to those in Europe (8.5%), Africa (8.2), and Asia (4%). Meta-regression showed that increased sensitivity of antibodies test was associated with increased seroprevalence. The following factors were associated with seropositivity: male gender, Black, Asian, and Hispanic HCWs, work in a coronavirus disease 2019 (COVID-19) unit, patient-related work, frontline health care workers, health care assistants, personal protective equipment shortage, self-reported belief for previous SARS-CoV-2 infection, previous positive polymerase chain reaction test, and household contact with suspected or confirmed COVID-19 patients. Conclusion The seroprevalence of SARS-CoV-2 antibodies among HCWs is high. Excellent adherence to infection prevention and control measures, sufficient and adequate personal protective equipment, and early recognition, identification and isolation of HCWs that are infected with SARS-CoV-2 are imperative to decrease the risk of SARS-CoV-2 infection.

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“…Based on our findings we further evaluated the ABBOTT SARS-CoV-2 IgG assay in a cohort of 305 negative samples (before the evolution of SARS-CoV-2) and we obtained similar results (Sp 99.7% with 95% CI: 98.2-100%). These results have been presented in a recent manuscript estimating the prevalence of IgG antibodies in Greece during March and April 2020 (22).…”

Section: Discussionmentioning

confidence: 75%

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Repeated leftover serosurvey of SARS-CoV-2 IgG antibodies, Greece, March and April 2020

Cited by 59 publications

References 6 publications

Seroprevalence of Antibodies against SARS-CoV-2 among the Personnel and Students of the National and Kapodistrian University of Athens, Greece: A Preliminary Report

Seroprevalence of Antibodies against SARS-CoV-2 among the Personnel and Students of the National and Kapodistrian University of Athens, Greece: A Preliminary Report

Seroprevalence of SARS-CoV-2 antibodies and associated factors in healthcare workers: a systematic review and meta-analysis

Table_1.docx

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