Repeated intravenous administrations of teneurin-C terminal associated peptide (TCAP)-1 attenuates reinstatement of cocaine seeking by corticotropin-releasing factor (CRF) in rats

Erb, Suzanne; McPhee, Matthew; Brown, Zenya J.; Kupferschmidt, David A.; Song, Ling; Lovejoy, David A.

doi:10.1016/j.bbr.2014.04.013

Cited by 21 publications

(21 citation statements)

References 24 publications

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“…[ 105 ] In corroboration of these cellular actions, synthetic TCAP‐1 regulates anxious, depressive, and addictive behaviors in rats. [ 93,107–111 ] Moreover, modulation of mitochondrial activity by TCAP‐1 has been implicated in both in vitro [ 112 ] and in vivo [ 105 ] studies. Importantly, this peptide antagonizes the action of CRF in vivo and in vitro.…”

Section: Finding the Ancestor Of Crf And The Secretin Family Of Peptidesmentioning

confidence: 99%

Information Processing in Affective Disorders: Did an Ancient Peptide Regulating Intercellular Metabolism Become Co‐Opted for Noxious Stress Sensing?

Lovejoy

Hogg

2020

BioEssays

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Affective disorders arise in stressful situations from aberrant sensory information integration that affects energetic nutrient (i.e., glucose) utilization to the cognitive centers of the brain. Because energy flow is mediated by molecular signals and receptors that evolved before the first complex brains, the phylogenetically oldest signaling systems are essential in the etiology of affective disorders. The corticotropin‐releasing factor (CRF) peptide subfamily is a phylogenetically old metazoan peptide family and is pivotal for regulating organismal energy response associated with stress. Highly conserved, both the CRF peptide family and its receptors possess a structural relationship to the teneurins, and their receptors, latrophilins, respectively. The CRF homologous region of teneurin is defined as the “teneurin C‐terminal associated peptide” (TCAP) and antagonizes CRF action, regulates mitochondrial energy production, and is anxiolytic in vivo. Here, it is postulated that TCAP represents an ancient peptide that mediates intercellular information transfer of stressful and noxious events by regulating energy utilization among neurons.

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Section: Finding the Ancestor Of Crf And The Secretin Family Of Peptidesmentioning

confidence: 99%

Information Processing in Affective Disorders: Did an Ancient Peptide Regulating Intercellular Metabolism Become Co‐Opted for Noxious Stress Sensing?

Lovejoy

Hogg

2020

BioEssays

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“…TCAP-1 blocked CRF-mediated c-fos synthesis in the hippocampus and amygdala of the adult rat (Tan et al, 2009 ) and increased spine density in the CA1 and CA3 neurons of the rodent hippocampus but not in the amygdala (Tan et al, 2011 ). Moreover, repeated ICV and IV TCAP- 1 administration ablates CRF-induced cocaine-seeking reinstatement in rats (Kupferschmidt et al, 2011 ; Erb et al, 2014 ).…”

Section: Cognitive and Behavioral Effects Of The Teneurin/tcap-lphn Smentioning

confidence: 99%

Ancient interaction between the teneurin C-terminal associated peptides (TCAP) and latrophilin ligand-receptor coupling: a role in behavior

et al. 2015

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Teneurins are multifunctional transmembrane proteins that are found in all multicellular animals and exist as four paralogous forms in vertebrates. They are highly expressed in the central nervous system, where they exert their effects, in part, by high-affinity binding to latrophilin (LPHN), a G-protein coupled receptor (GPCR) related to the adhesion and secretin GPCR families. The teneurin C-terminal associated peptides (TCAPs) are encoded by the terminal exon of all four teneurins, where TCAPs 1 and 3 are independently transcribed as soluble peptides, and TCAPs 2 and 4 remain tethered to their teneurin proprotein. Synthetic TCAP-1 interacts with LPHN, with an association with β-dystroglycan, to induce a tissue-dependent signal cascade to modulate cytoskeletal dynamics. TCAP-1 reduces stress-induced behaviors associated with anxiety, addiction and depression in a variety of models, in part, by regulating synaptic plasticity. Therefore, the TCAP-1-teneurin-LPHN interaction represents a novel receptor-ligand model and may represent a key mechanism underlying the association of behavior and neurological conditions.

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“…It has not been determined beyond doubt to date which of them is the ligand and which the signal-receiving molecule or if both of them signal. However, some studies show that Teneurins are cleaved at several distinct sites rendering liberated fragments (Wang et al, 2005), which are involved in different functions in the brain such as neurite outgrowth (Al Chawaf et al, 2007a; Erb et al, 2014). It has been suggested that one of these TEN2 fragments, generated by regulated proteolysis, is soluble and can still bind LPHN1 and trigger signaling (Silva et al, 2011; Vysokov et al, 2016, 2018) indicating that LPHN1 is the receptor transducing information into the cell.…”

Section: Latophilins and Teneurins Form A Transsynaptic Complex In Mamentioning

confidence: 99%

Latrophilins and Teneurins in Invertebrates: No Love for Each Other?

Schöneberg

Prömel

2019

Front. Neurosci.

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Transsynaptic connections enabling cell–cell adhesion and cellular communication are a vital part of synapse formation, maintenance and function. A recently discovered interaction between the Adhesion GPCRs Latrophilins and the type II single transmembrane proteins Teneurins at mammalian synapses is vital for synapse formation and dendrite branching. While the understanding of the effects and the molecular interplay of this Latrophilin-Teneurin partnership is not entirely understood, its significance is highlighted by behavioral and neurological phenotypes in various animal models. As both groups of molecules, Latrophilins and Teneurins, are generally highly conserved, have overlapping expression and often similar functions across phyla, it can be speculated that this interaction, which has been proven essential in mammalian systems, also occurs in invertebrates to control shaping of synapses. Knowledge of the generality of this interaction is especially of interest due to its possible involvement in neuropathologies. Further, several invertebrates serve as model organisms for addressing various neurobiological research questions. So far, an interaction of Latrophilins and Teneurins has not been observed in invertebrates, but our knowledge on both groups of molecules is by far not complete. In this review, we give an overview on existing experimental evidence arguing for as well as against a potential Latrophilin-Teneurin interaction beyond mammals. By combining these insights with evolutionary aspects on each of the interaction partners we provide and discuss a comprehensive picture on the functions of both molecules in invertebrates and the likeliness of an evolutionary conservation of their interaction.

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Repeated intravenous administrations of teneurin-C terminal associated peptide (TCAP)-1 attenuates reinstatement of cocaine seeking by corticotropin-releasing factor (CRF) in rats

Cited by 21 publications

References 24 publications

Information Processing in Affective Disorders: Did an Ancient Peptide Regulating Intercellular Metabolism Become Co‐Opted for Noxious Stress Sensing?

Information Processing in Affective Disorders: Did an Ancient Peptide Regulating Intercellular Metabolism Become Co‐Opted for Noxious Stress Sensing?

Ancient interaction between the teneurin C-terminal associated peptides (TCAP) and latrophilin ligand-receptor coupling: a role in behavior

Latrophilins and Teneurins in Invertebrates: No Love for Each Other?

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