Repeated high‐frequency transcranial magnetic stimulation over the dorsolateral prefrontal cortex reduces cigarette craving and consumption

Amiaz, Revital; Levy, Dino J.; Vainiger, Dana; Grunhaus, Leon; Zangen, Abraham

doi:10.1111/j.1360-0443.2008.02448.x

Cited by 272 publications

(210 citation statements)

References 48 publications

(56 reference statements)

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“…Although DA-containing neurons are located deeply in the brainstem, making them inaccessible to direct rTMS stimuli, DA neurons may be reached indirectly through neurons located elsewhere in the brain. For example, the dorsolateral prefrontal cortex (DLPfcx), the brain region targeted in many rTMS studies (eg, Amiaz et al, 2009), projects monosynaptically to the VTA, which contains the cell bodies of DA-producing cells (Carr and Sesack, 2010). Indeed, these cortical neurons could be 'used' as the primary target of the rTMS stimulus to produce, ultimately, an increase in DA availability in the synaptic cleft in the Nacc.…”

Section: Future Research Directions: Transcranial Magnetic Stimulationmentioning

confidence: 99%

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

Addolorato

Leggio

Hopf

et al. 2011

Neuropsychopharmacol

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Drug addiction represents a major social problem where addicts and alcoholics continue to seek and take drugs despite adverse social, personal, emotional, and legal consequences. A number of pharmacological compounds have been tested in human addicts with the goal of reducing the level or frequency of intake, but these pharmacotherapies have often been of only moderate efficacy or act in a sub-population of humans. Thus, there is a tremendous need for new therapeutic interventions to treat addiction. Here, we review recent interesting studies focusing on gamma-aminobutyric acid receptors, voltage-gated ion channels, and transcranial magnetic stimulation. Some of these treatments show considerable promise to reduce addictive behaviors, or the early clinical studies or pre-clinical rationale suggest that a promising avenue could be developed. Thus, it is likely that within a decade or so, we could have important new and effective treatments to achieve the goal of reducing the burden of human addiction and alcoholism.

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Section: Future Research Directions: Transcranial Magnetic Stimulationmentioning

confidence: 99%

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

Addolorato

Leggio

Hopf

et al. 2011

Neuropsychopharmacol

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“…Although no difference in craving was found, the results illustrated an advantage of TMS in smoking cessation [28]. Meanwhile, Johann et al demonstrated that rTMS can also reduce cigarette craving [29]; this effect was replicated in a subsequent study using a more rigorous experimental design and a larger group of participants [30]. This study demonstrated that rTMS over the dlPFC reduces both cigarette consumption and craving, though the effects were not robust and seemed to dissipate over time [30].…”

Section: Evidence Supporting Tms As a Treatmentmentioning

confidence: 76%

“…Meanwhile, Johann et al demonstrated that rTMS can also reduce cigarette craving [29]; this effect was replicated in a subsequent study using a more rigorous experimental design and a larger group of participants [30]. This study demonstrated that rTMS over the dlPFC reduces both cigarette consumption and craving, though the effects were not robust and seemed to dissipate over time [30]. Furthermore, rTMS may serve as an additional aid in cognitive-behavioral therapy for intermediate nicotine abstinence [31].…”

Section: Evidence Supporting Tms As a Treatmentmentioning

confidence: 78%

Non-invasive Brain Stimulation for the Treatment of Nicotine Addiction: Potential and Challenges

Yang

Zhang

2016

Neurosci. Bull.

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Tobacco consumption is one of the leading causes of preventable death worldwide. However, it is difficult to give up smoking by relying on the help of traditional treatments only. Recent years have witnessed emerging positive evidence that non-invasive brain stimulation (NIBS), such as transcranial magnetic stimulation and transcranial direct-current stimulation, can reduce smoking-related behaviors. Although their potential has been implied by advances in research, several methodological issues restrict the clinical application of NIBS to treating nicotine dependence. In this review, we critically evaluate related studies and give suggestions for future research and applications to meet these challenges.

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“…In addition, studies successfully employing brain stimulation of the prefrontal cortex as treatment in nicotine dependent individuals further argues for the role of plasticity executive function across nicotine addiction and recovery [33,34].…”

Section: Journal Of Addiction Research and Therapymentioning

confidence: 99%

Changes in Executive Function Following Short-Term Tobacco Cessation Therapy in College Students

Meil¹,

Sesti²,

Desai³

et al. 2017

J Addict Res Ther

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Objective: Evidence has been accumulating regarding the role of executive deficits in nicotine addiction; however, little is known as to whether executive abilities change as a function of treatment for nicotine dependence. The purpose of this study was to investigate whether executive function improves following short-term tobacco cessation therapy. Methods:College students (N=17) expressing an interest in tobacco cessation therapy involving Motivational Interviewing Therapy with or without the nicotine patch were administered the self-report Frontal Systems Behavioral Scale (FrSBe), the performance-based Delis-Kaplan Executive Function System (D-KEFS) and the Fagerstrom Test of Nicotine Dependence (FTND) prior to treatment and approximately 1.5 months later. A group of non-smoking college students (N=19) was also administered the same measures of executive function across the same time period.Results: Prior to treatment smokers had significantly higher FrSBe Apathy subscale scores compared to nonsmokers. Acute tobacco cessation therapy significantly decreased nicotine dependence as measured by the FTDN. After controlling for pre-treatment scores, a significant difference emerged between tobacco cessation participants and non-smoking controls on post-test FrSBe Disinhibition scores. Post hoc analyses revealed a significant improvement in FrSBe Disinhibition scores among tobacco cessation participants, but no change among nonsmokers. Conclusion:While caution is warranted due to the small sample size of this study, these results suggest selfreport measures of executive function maybe more sensitive to executive deficits among smokers and change following short-term tobacco cessation therapy, particularly measures indicative of an improved ability to inhibit impulses and behavior. These results also highlight the multidimensional nature of executive function.

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Repeated high‐frequency transcranial magnetic stimulation over the dorsolateral prefrontal cortex reduces cigarette craving and consumption

Abstract: Multiple high-frequency rTMS of the DLPFC can attenuate nicotine craving.

Cited by 272 publications

References 48 publications

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

Non-invasive Brain Stimulation for the Treatment of Nicotine Addiction: Potential and Challenges

Changes in Executive Function Following Short-Term Tobacco Cessation Therapy in College Students

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