Repeated Hepatic Resection for Recurrent Hepatocellular Carcinoma - In 15 Cases.

Growth Rate of Locally Recurrent Hepatocellular Carcinoma After Transcatheter Arterial Chemoembolization: Comparing the Growth Rate of Locally Recurrent Tumor with That of Primary Hepatocellular Carcinoma

“…As reported by many authors, intrahepatic recurrence after the initial therapy for HCC is very common, with fewer than 50% of the patients showing disease-free survival for 3 to 5 years [11,12]. Liver resection for recurrent HCC is a potentially curative intervention; however, in most cases, multifocality of the tumor, deteriorating liver function, and increasing portal hypertension prevent patients from undergoing surgery [13,14].…”

Radiation therapy for intrahepatic recurrence after hepatectomy for hepatocellular carcinoma

“…The reported resection rates of recurrent HCC range from 10% to 48%, and the 3-year survival rates after second hepatectomy range from 21% to 87%. [4][5][6]14,15 Patients who underwent repeat hepatectomy for recurrent HCC were comparable to the patients with no recurrence in terms of their cumulative survival rates from the first hepatectomy. 4,16 However, indications for hepatectomy are restricted by the patient's liver function and the type of recurrence.…”

“…1,2 However, recurrence was observed in 51.0%-68.6% of patients after curative hepatectomy, with most recurrences being restricted to the remnant liver. [3][4][5][6] Therefore, the treatment for recurrent HCC is essentially the same as that for primary HCC. Radiation therapy (RT) for HCC has been used less commonly than surgical resection, TAE, or PEIT, although the effectiveness of RT has been reported for unresectable HCC.…”

Treatment Strategy for Recurrent Hepatocellular Carcinoma

“…It should be the treatment of choice in suitable patients with preserved liver function and functional status. The safety and long-term results of repeated resection has been well-established, with operative mortality rates ranging from 0% to 8.5% and the reported cumulative 5-year survival rate after a second hepatectomy was comparable to the survival after initial hepatectomy for primary HCC (Aeii et al, 1998;Farges et al, 1998;Hu et al, 1996;Itamota et al, 2000;Kakazu et al, 1993;Matsuda Y et al, 1993;Minagawa et al, 2003;Nagano et al, 2009;Nagasue et al, 1996;Poon et al, 1999;Shimada et al, 1996Shimada et al, , 1998Suenaga M et al, 1994;Sugimachi et al, 2001;Zhou et al, 2010).…”