Repeated fasting events sensitize enhancers, transcription factor activity and gene expression to support augmented ketogenesis
Noga Korenfeld,
Meital Charni-Natan,
Justine Bruse
et al.
Abstract:Mammals withstand frequent and prolonged fasting periods due to hepatic production of ketone bodies. Because the fasting response is transcriptionally-regulated, we asked whether enhancer dynamics impose a transcriptional program during recurrent fasting and whether this generates effects distinct from a single fasting bout. We found that mice undergoing alternate-day fasting (ADF) respond profoundly differently to a following fasting bout compared to mice first experiencing fasting. Hundreds of genes enabling… Show more
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