Imaging of the spine is increasingly available, whether as dedicated spine examinations or as studies that include the spine in the images obtained (e.g. CT abdomen). This pictorial review discusses imaging of the spine with CT and MRI and how prior review of this imaging can be helpful with potentially difficult spinal procedures. Pathologies illustrated include osteoarthritis, scoliosis, inflammatory spondyloarthropathies and post-operative spines.Many spinal procedures are performed using the interspinous (midline) or interlaminar (paramedian) approach with high success rates. These procedures include myelograms for diagnosis, epidural corticosteroid injections for pain relief, central neuraxial blocks in regional anaesthesia and lumbar punctures for cerebrospinal fluid (CSF) analysis. The causes for difficult spinal procedures are wide in range and include pathological/ anatomical conditions of the spine. As with all imaging as a whole, spinal imaging is increasingly more available with each individual patient [1], and review of such imaging can be helpful for difficult procedures.This pictorial review will discuss imaging (CT, MRI) of spinal conditions that can contribute to difficult spinal procedures, in particular osteoarthritis, scoliosis and the inflammatory spondyloarthropathies. The illustrations will focus on the