Repeated exposures to chlorpyrifos lead to spatial memory retrieval impairment and motor activity alteration

Yan, Cong; Jiao, Lifei; Zhao, Jun; Yang, Haiying; Peng, Shuangqing

doi:10.1016/j.ntt.2012.05.053

Cited by 32 publications

(27 citation statements)

References 60 publications

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“…These animal tasks include delayed matching (working memory), water maze (spatial learning and memory) novel object recognition (recognition memory), and the performance of the five-choice serial reaction time task (sustained attention) (Bushnell et al, 1991;Terry et al, 2003Terry et al, , 2007Terry et al, , 2011Middlemore-Risher et al, 2010;Yan et al, 2012;Terry et al, 2014).…”

mentioning

confidence: 99%

Repeated exposure to chlorpyrifos leads to prolonged impairments of axonal transport in the living rodent brain

et al. 2015

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mentioning

confidence: 99%

Repeated exposure to chlorpyrifos leads to prolonged impairments of axonal transport in the living rodent brain

et al. 2015

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“…У водному тесті не лише збіль-шувався час, необхідний тваринам для запам'ятовування положення підводної платформи, але й виникали труднощі з виявленням платформи після зміни її по-ложення (зниження гнучкості мислення) [12,13].…”

Section: вступunclassified

“…Це корелює з літературними даними [4,[11][12][13], згідно з якими одним з основних негативних наслідків впливу ХПФ на нервову систему є погіршення пам'яті.…”

Section: результати та їх обговоренняunclassified

The Effect of Chronic Intoxication With Low Doses of Chlorpyrifos on the Behavioral Parameters of Female Rats

Grabovska¹,

Salyha²

2015

Fiziol Zh

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“…By inhibiting the enzyme cleavage of acetylcholine, synapses are not allowed to reset, which may result in death at high doses in adults and in neurodevelopmental abnormality in children at lower doses. Residential studies of exposure to the OP chlorpyrifos have shown reductions in working memory, reductions in intelligence, and brain anomalies in the babies of exposed mothers (25)(26)(27)(28)(29), as well as in laboratory animal experiments (30). Studies of acute exposure to these compounds have resulted in restrictions on the use of some OPs in both occupational and residential settings.…”

mentioning

confidence: 99%

Human Oral Buccal Microbiomes Are Associated with Farmworker Status and Azinphos-Methyl Agricultural Pesticide Exposure

Stanaway

Wallace

Shojaie

et al. 2017

Appl Environ Microbiol

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In a longitudinal agricultural community cohort sampling of 65 adult farmworkers and 52 adult nonfarmworkers, we investigated agricultural pesticide exposure-associated changes in the oral buccal microbiota. We found a seasonally persistent association between the detected blood concentration of the insecticide azinphos-methyl and the taxonomic composition of the buccal swab oral microbiome. Blood and buccal samples were collected concurrently from individual subjects in two seasons, spring/summer 2005 and winter 2006. Mass spectrometry quantified blood concentrations of the organophosphate insecticide azinphosmethyl. Buccal oral microbiome samples were 16S rRNA gene DNA sequenced, assigned to the bacterial taxonomy, and analyzed after "centered-log-ratio" transformation to handle the compositional nature of the proportional abundances of bacteria per sample. Nonparametric analysis of the transformed microbiome data for individuals with and without azinphos-methyl blood detection showed significant perturbations in seven common bacterial taxa (Ͼ0.5% of sample mean read depth), including significant reductions in members of the common oral bacterial genus Streptococcus. Diversity in centered-log-ratio composition between individuals' microbiomes was also investigated using principal-component analysis (PCA) to reveal two primary PCA clusters of microbiome types. The spring/summer "exposed" microbiome cluster with significantly less bacterial diversity was enriched for farmworkers and contained 27 of the 30 individuals who also had azinphos-methyl agricultural pesticide exposure detected in the blood. IMPORTANCEIn this study, we show in human subjects that organophosphate pesticide exposure is associated with large-scale significant alterations of the oral buccal microbiota composition, with extinctions of whole taxa suggested in some individuals. The persistence of this association from the spring/summer to the winter also suggests that long-lasting effects on the commensal microbiota have occurred. The important health-related outcomes of these agricultural community individuals' pesticide-associated microbiome perturbations are not understood at this time. Future investigations should index medical and dental records for common and chronic diseases that may be interactively caused by this association between pesticide exposure and microbiome alteration.KEYWORDS farmworkers, azinphos-methyl, oral, microbiome, bacteria, buccal mucosa, 16S rRNA, sequencing

show abstract

Repeated exposures to chlorpyrifos lead to spatial memory retrieval impairment and motor activity alteration

Cited by 32 publications

References 60 publications

Repeated exposure to chlorpyrifos leads to prolonged impairments of axonal transport in the living rodent brain

Repeated exposure to chlorpyrifos leads to prolonged impairments of axonal transport in the living rodent brain

The Effect of Chronic Intoxication With Low Doses of Chlorpyrifos on the Behavioral Parameters of Female Rats

Human Oral Buccal Microbiomes Are Associated with Farmworker Status and Azinphos-Methyl Agricultural Pesticide Exposure

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