Repeated exposure to social stress alters the development of agonistic behavior in male golden hamsters

Wommack, Joel C.; Taravosh-Lahn, Kereshmeh; David, Jesuye; Delville, Yvon

doi:10.1016/s0018-506x(02)00029-6

Cited by 77 publications

(77 citation statements)

References 16 publications

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“…Given differences in corticosterone between genotype, we cannot rule out a role for glucocorticoids in our findings. Interestingly, in hamsters higher attacks to the belly region occur with transitions to adulthood from puberty and exposure to stressors (or glucocorticoids) accelerates the production of attacks to the region [9,43,44]. Thus, lower attacks to the ventral portion of the mid-section (including belly) of the intruder by KO mice would be consistent with lower glucorticoid activity in these mice.…”

Section: Discussionmentioning

confidence: 84%

Intermale aggression in corticotropin-releasing factor receptor 1 deficient mice

Gammie

Stevenson

2006

Behavioural Brain Research

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The anxiogenic neuropeptide, corticotropin-releasing factor (CRF), has a complex effect on intermale aggression. CRF receptor 1 (CRFR1) is the primary receptor for CRF and in this study, we examined in detail isolation-induced intermale aggression in CRFR1 deficient mice. All mice contained a mixed 50:50 inbred/outbred background to improve aggressive performance. Mice were isolated for 4 weeks prior to two consecutive days of aggression testing using the resident-intruder paradigm. Mice were also tested for anxiety on the elevated plus maze. Relative to littermate wild-type (WT) controls, CRFR1-mutant mice exhibited normal levels of intermale aggression over the two test days in terms of percentage showing aggression, number of attacks, time aggressive, and latency to first attack. In terms of sites of attacks on intruders, CRFR1-deficient mice attacked the ventral portion of the midsection (including belly) significantly less frequently than WT males on test day 1, but these differences did not reach significance on test day 2. No other differences in sites of attacks were observed. Tail rattling also did not differ between groups. Importantly, KO males showed decreased anxiety relative to WT mice (consistent with previous reports) as evidenced by spending significantly more time on the open arms and significantly less time on the closed arms of the elevated plus maze. Plus maze performance did not correlate with any measure of levels of aggression, suggesting a dissociation between altered levels of anxiety and aggressive performance. Taken together, the results suggest that the activation CRFR1 is not necessary for the normal production of isolation-induced intermale aggression.

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Section: Discussionmentioning

confidence: 84%

Intermale aggression in corticotropin-releasing factor receptor 1 deficient mice

Gammie

Stevenson

2006

Behavioural Brain Research

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“…When stressful conditions are present during development, effects can be measured in the neural circuitries that regulate both aggression and stress, and in some brain regions those circuitries coincide. Repeated or chronic stress applied during puberty accelerates the progression of development of aggressive behaviors in male hamsters (Wommack et al, 2003;Delville et al, 2003), accompanied by neuroendocrine changes in brain regions like medial amygdala and bed nucleus of the stria terminalis (BNST) that are active in both stress and aggression (Wommack et al, 2004). Stressful conditions such as frustration (absence of reward) stimulates a significant increase in synaptic activity in the neural circuitry controlling aggression (David et al, 2004).…”

Section: Cross Linkage Of Aggression and Stress Circuitrymentioning

confidence: 99%

Interactions between the neural regulation of stress and aggression

Summers

Winberg

2006

Journal of Experimental Biology

177

155

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Socially aggressive interaction is stressful. What is more, social aggression is stressful for both dominant and subordinate animals. Much of the neurocircuitry for stress and aggression overlap. The pattern of neurochemical and hormonal events stimulated by social interaction make it clear that subtle differences in this pattern of response distinguish social rank. The neurotransmitter serotonin (5-HT) responds rapidly to stress, and also appears to play the most important role for inhibitory regulation of aggressive interactions. In addition, the adrenocortical/ interrenal steroid hormones corticosterone and cortisol are responsive to stress and influence aggression. However, while 5-HT and glucocorticoids can both be inhibitory to aggression, the relationship between 5-HT and glucocorticoids is not straightforward, and much of the distinctions in function depend upon timing. Neither is inhibitory during the early stressful phase of aggression. This transmitter-hormone combination follows and influences a four-stage functional pattern of effect: (1) predisposed (positively or negatively) toward aggression, (2) motivated toward behavior, (3) responsive to stress (including aggression) and passively allowing aggression, and finally (4) chronically applied 5-HT and glucocorticoids inhibit aggression.Key words: antagonism, attack, corticosterone, cortisol, dominant, dopamine (DA), fight, hostility, serotonin (5-HT), social stress, stages, subordinate, timeline. territorial animals that must constantly protect resources, most of the time aggressive tendencies are held in check. Revealing aggressive potential is the consequence of numerous provocations in the normal life history of most animals and humans. Therefore, in this review, we will consider neural systems that stimulate aggression, but we will focus on inhibitory regulation. That inhibitory regulation emanates primarily from one neurotransmitter system, serotonin (5-HT) (Nelson and Chiavegatto, 2001), but it is far from simple. Its complex nature is derived from neuroendocrine relationships between stress and aggression. The timeline on which these two interacting systems are co-expressed take place before, during and after socially aggressive interaction (Fig.·1). The timeline is suggested as a model of aggressive interaction in all vertebrates, but we especially draw from examples of evolutionarily conserved behavior and neuroendocrine adaptation in fish and lizards (Winberg and Nilsson, 1993;Summers et al., 2005c). We describe neurotransmitter and hormonal responses during four stages, where they: (1) influence predisposition (positively or negatively) toward aggression, (2) motivate behavior (3) are responsive to stress (including aggression) but passively allow aggression and finally (4) may chronically inhibit aggression. Summary Aggression neurocircuitryExperimental inhibitory effects of 5-HT on aggressive behavior are most often the result of systemic application of serotonergic drugs, like selective 5-HT reuptake inhibitors (SSRI; usually a stage 4...

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“…The majority of bites performed by adults are focused on the lower belly and rump. This transition in the focus of attacks occurs around mid-puberty as testicles start growing and serum testosterone levels start rising (Wommack et al, 2003). In this study, we found that more fighting occurred as juvenile crayfish became larger.…”

Section: Development Of Agonistic Bouts During Growth Of Crayfishmentioning

confidence: 53%

“…Only in male golden hamsters has agonistic behaviour been characterized as maturing during puberty, changing from play fighting to adult aggression (Goldman and Swanson, 1975). Juvenile play fighting is characterized by more repetitive attacks and contact bouts during agonistic interactions than that in adults (Goldman and Swanson, 1975;Wommack et al, 2003). In addition, hamsters target different parts on the body of opponents during play fighting and adult aggression.…”

Section: Development Of Agonistic Bouts During Growth Of Crayfishmentioning

confidence: 99%

“…This behaviour is initiated before puberty and gradually matures into adult aggression in late puberty. Juveniles are a lot more active than adults during agonistic encounters and perform more attacks and bites than adults (Goldman and Swanson, 1975;Wommack et al, 2003). The majority of bites performed by adults are focused on the lower belly and rump, while attacks and bites performed by juveniles during play fighting are mainly focused on the cheeks and face (Pellis and Pellis, 1988;Wommack et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Development of agonistic encounters in dominance hierarchy formation in juvenile crayfish

Sato

Nagayama

2012

Journal of Experimental Biology

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SUMMARYWe have characterized the behavioural patterns of crayfish during agonistic bouts between groups of crayfish of four different body lengths (9-19, 20-32, 41-48 and 69-75mm) to characterize changes in the patterns of agonistic encounter during development. The behaviour of both dominant and subordinate animals was analysed by single frame measurement of video recordings. Behavioural acts that occurred during agonistic bouts were categorized as one of seven types: capture, fight, contact, approach, retreat, tailflip and neutral. Dominant-subordinate relationships were formed between juvenile crayfish as early as the third stage of development. Patterns of agonistic bouts to determine social hierarchy became more aggressive during development. The dominant-subordinate relationship was usually determined after contact in crayfish of less than 20mm and 20-32mm in length, while several bouts of fights were necessary for crayfish of 41-48 and 69-75mm in length. Furthermore, social hierarchy was formed more rapidly in small crayfish. In larger animals, the number of approaches by dominant animals that promoted retreat in subordinate animals increased after the establishment of the winner-loser relationship. In smaller crayfish, in contrast, no measurable changes in these behaviour patterns were observed before and after the establishment of the winner-loser relationship. With increasing body size, the probability of tailflips decreased while that of retreats increased as the submissive behavioural act of subordinate animals.

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Repeated exposure to social stress alters the development of agonistic behavior in male golden hamsters

Cited by 77 publications

References 16 publications

Intermale aggression in corticotropin-releasing factor receptor 1 deficient mice

Intermale aggression in corticotropin-releasing factor receptor 1 deficient mice

Interactions between the neural regulation of stress and aggression

Development of agonistic encounters in dominance hierarchy formation in juvenile crayfish

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