Repeated Dose Oral Toxicity Study of Alismatis Rhizoma in SD Rats

Roh, Hang-Sik; Seok, Ji-Hyun; Jeong, Jayoung; Lee, Jong‐Kwon; Kim, Taesung; Choi, Hye-Kyung; Ha, Hun-Yong

doi:10.6114/jkood.2014.27.1.079

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…According to the previous reports, a single oral administration of ARAE did not induce any toxic effect at a dose of ≤ 4,000 mg/kg in rats (18), and the NOAEL in a 14-day repeated oral dose toxicity study was assumed as over 2,000 mg/kg/day (19). A 60-day oral dose toxicity study showed that some renal function parameters can be affected by a high dose (33.3 g/kg/day) of ARAE in male rats, but histopathological changes were not observed at any doses tested (15).…”

Section: Discussionmentioning

confidence: 99%

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A 90-Day Repeated Oral Dose Toxicity Study of Alismatis Rhizoma Aqueous Extract in Rats

et al. 2019

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Alismatis rhizoma (AR), the dried rhizome of Alisma orientale (Sam.) Juzep, is a well-known, traditional medicine that is used for the various biological activities including as a diuretic, to lower cholesterol and as an anti-inflammatory agent. The present study was carried out to investigate the potential toxicity of the Alismatis rhizoma aqueous extract (ARAE) following 90-day repeated oral administration to Sprague-Dawley rats. ARAE was administered orally to male and female rats for 90 days at 0 (control), 500, 1,000 and 2,000 mg/kg/day ( n = 10 for male and female rats for each dose). Additional recovery groups from the control group and high dose group were observed for a 28-day recovery period. Chromatograms of ARAE detected main compounds with four peaks. Treatment-related effects including an increase in the red blood cells, hemoglobin, hematocrit, albumin, total protein, and urine volume were observed in males of the 2,000 mg/kg/day group ( p < 0.05). However, the diuretic effect of ARAE was considered, a major cause of hematological and serum biochemical changes. The oral no-observed-adverse-effect level (NOAEL) of the ARAE was > 2,000 mg/kg/day in both genders, and no target organs were identified.

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Section: Discussionmentioning

confidence: 99%

“…A dose of 2,000 mg/kg/day was set as the high dose based on the results of a preliminary 2-week repeated oral dose toxicity study (19) and the characteristics of the natural test substance. Doses of 1,000 and 500 mg/kg/day were set as the middle and low doses, respectively, using a common ratio of 2.…”

Section: Methodsmentioning

confidence: 99%

A 90-Day Repeated Oral Dose Toxicity Study of Alismatis Rhizoma Aqueous Extract in Rats

et al. 2019

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Evaluation of 3-week Repeated Dose Oral Toxicity on Amomum tsao-ko Extract in Balb/c Mice

Park

Cho

et al. 2015

JABC

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In the present study, we investigated the oral toxicity of Amomum tsao-ko Crevost et Lemaire, (Zingiberaceae) extract in Balb/c mice (BALB, n=60) for 3 weeks. Balb/c mice (10 mice/ group, 6 group, 20±2 g, 6 weeks) were orally administered for 21 days, with dosage of 250, 500, 1000, 2000 mg/kg/day. Ethanol extract of A. tsao-ko did not affect any significant change of mortality, clinical signs, organs and body weights. Also, there were not significantly difference from the naive group (control) in hematological and serum biochemical examination. Consequently, these findings indicate that 3-week treatment with the ethanol extract of A. tsao-ko was not any toxic effects in Balb/c mice and the no-observed adverse effect level (NOAEL) for oral toxicity was determined to be 2000 mg/kg/day under our experimental conditions. Keywords 3-week repeated-dose oral toxicity • Amomum tsaoko • Balb/c mouse • hematology • serum biochemical examination 서 론

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3-week repeated dose oral toxicity study of Clausena excavata extract in ICR mice

Park

rak

Min

et al. 2019

JABC

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Medicinal herb in Asian countries has been traditionally used for a long time. However, the safety and adverse effect of medicinal herb have not been established yet. The aim of this study is to evaluate toxicity in the oral administration of Clausena excavata (C. excavata) in male ICR mice for 3 weeks and the noobserved adverse effect level (NOAEL). C. excavata has been used as a medicinal herb for the treatment of dermatopathy, malaria, abdominal pain, dysentery, and enteritis. C. excavata was orally administered daily for 21 days at a dose of 100, 250, 500, 1000, and 2000 mg/kg/day (MPK). There were no significant differences in mortalities, clinical signs, body weight changes, hematological, and serum biochemistry examination in all animals administrated with C. excavate. Consequently, these findings indicated that C. excavata did not affect the toxic effect in ICR mice and the NOAEL of C. excavata was considered as more than 2000 MPK. Keywords 3-week repeated-dose oral toxicity • Clausena excavata • ICR mouse • No-observed adverse effect level

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Repeated Dose Oral Toxicity Study of Alismatis Rhizoma in SD Rats

Cited by 5 publications

References 2 publications

A 90-Day Repeated Oral Dose Toxicity Study of Alismatis Rhizoma Aqueous Extract in Rats

A 90-Day Repeated Oral Dose Toxicity Study of Alismatis Rhizoma Aqueous Extract in Rats

Evaluation of 3-week Repeated Dose Oral Toxicity on Amomum tsao-ko Extract in Balb/c Mice

3-week repeated dose oral toxicity study of Clausena excavata extract in ICR mice

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