Repeated Anaphylactic Responses Induced by Oral Challenge with Ranitidine

Walker, Annett; Werfel, Sabine; Kick, Gerold; Przybilla, Bernhard

doi:10.2340/00015555-0773

Cited by 10 publications

(10 citation statements)

References 10 publications

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“…[3] Ranitidinin hipersensitiviteye hangi mekanizma yol açtığı tam olarak bilinmemekle birlikte, IgE aracılıklı reaksiyonlar ve nonimmünolojik mekanizmalar suçlanmaktadır. [3,5] İlaç alerjisi tanısında ayrıntılı anamnez ve fizik muayene esastır. [9] Klinik bulguların şiddetine göre anafilaksi, Evre 1; deri bulguları, Evre 2; deri tutulum, arteriyel hipotansiyon, solunum güçlüğü veya öksürük, Evre 3; hayati tehdit eden kardiyovasküler kollaps, taşikardi veya bradikardi, aritmi ve şid-detli bronkospazm, Evre 4; dolaşım yetmezliği, kardiyak arrest ve/veya respiratuvar arrest olarak sınıflandırılmaktadır.…”

Section: Discussionunclassified

“…Walker ve ark. [5] ile Koh ve ark. [4] olgumuza benzer şekilde oral ranitidin alımını takiben anafilaktik reaksiyon gelişen ve epinefrin, steroid ve antihistaminik tedavi ile olguların düzeldiğini bildirmişlerdir.…”

Section: Discussionunclassified

“…[2] Ranitidine bağlı anafilaktik reaksiyonlar nadir olmakla beraber literatür-de mevcuttur. [1,[3][4][5] Bu yazıda, ranitidin oral alımı sonrasında acil servise başvu-ran ve yetersiz anamnez alınması nedeniyle, dispepsiye yö-nelik intravenöz (iv) ranitidin uygulanan ve anafilaktik reaksiyon gelişen olgu sunuldu.…”

Section: Introductionunclassified

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A Case Report: Anaphylactic Reaction due to Ranitidine

et al. 2011

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ÖZETRanitidin, peptik ülser ve gastroözefageal reflü tedavisinde yaygın olarak kullanılan selektif histamin 2 reseptör antagonistidir. Midede asit salgısını azaltarak etki göstermektedir. Bununla birlikte selektif histamin 2 reseptör antagonistleri, histamin 1 reseptör antagonistleri ile kombine olarak, kronik ürtiker, anafilaksi ve anjiyoö-dem tedavisinde de kullanılmaktadır. Histamin 2 reseptör antagonistlerinin kullanımında nadiren de olsa baş ağrısı, halsizlik, baş dönmesi, kabızlık, ishal, bradikardi, döküntü, jinekomasti ve anafilaksi gibi yan etkiler görülebilir. Bu yazıda, ranitidin kullanımına bağlı anafilaksi gelişen bir olgu literatür eşliğinde sunuldu.

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Section: Discussionunclassified

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A Case Report: Anaphylactic Reaction due to Ranitidine

et al. 2011

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“…Drug hypersensitivity reactions are commonly encountered in clinical practice, approximately 15% of the adverse drug reactions were observed in drug therapy. 1 The drug acts as an antigen and induces the development of various chemical mediators and antibodies that finally gives rise to an immense immunogenic reaction causing hypersensitivity. This response varies from person to person and depend on the type and dose of the drug, the age and genetic composition of the patient and the diseases.…”

Section: Introductionmentioning

confidence: 99%

“…This response varies from person to person and depend on the type and dose of the drug, the age and genetic composition of the patient and the diseases. 1 Thus, identification of these hypersensitive reactions, the causative drug, causality relationship between the drug and the reaction, are essential to optimize the therapeutic safety. Present case report deals with anaphylactic shock experienced by a patient, with a history of drug allergy to Ranitidine, immediately after cesarean delivery.…”

Section: Introductionmentioning

confidence: 99%

Proton Pump Inhibitor-induced Hypersensitivity Reaction: A Case Report

Adhikari¹,

Indu²,

Ray³

et al. 2017

JYP

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Introduction: Drug induced allergy or hypersensitivity reaction is of great clinical significance in therapeutics. Various factors may contribute like age, genetic composition, disease of the patients and the types of drugs used. Such reactions increases the patient's suffering and lowers the therapeutic efficacy of any drug. Therefore, it is essential to collect data and investigate important drug reactions for safe therapy. Presentation of Case: A 27-years old female patient, with a history of drug allergy to ranitidine, experienced severe anaphylactic shock immediately after cesarean delivery. Post-operative medications include Ceftriaxone, Metronidazole, Tramadol, Metoclopramide and Pantoprazole. With intravenous injections of Adrenaline, Hydrocortisone, Dexamethasone, Atropine, Promethazine and intubation, she slowly recovered after three days and was discharged. Conclusion: Past history of the patient suggested a rare case of drug allergy to ranitidine. Therefore, instead of ranitidine, pantoprazole was used for this patient. Clinicians suspected this anaphylactic reaction may be induced by drug. However, the drug responsible for this reaction was not detected clearly but Pantoprazole may be a possibility. Though allergy due to H 2 receptor antagonists and proton-pump inhibitors are rare but may cause fatal consequences. Thus proper investigation of this case may help in designing the treatment schedule in an effective way, in future.

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Current awareness: Pharmacoepidemiology and drug safety

2010

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 23 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Antidiabetic Agents; 21 Contrast Agents; 22 Bone Conservation Agents; 23 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Repeated Anaphylactic Responses Induced by Oral Challenge with Ranitidine

Cited by 10 publications

References 10 publications

A Case Report: Anaphylactic Reaction due to Ranitidine

A Case Report: Anaphylactic Reaction due to Ranitidine

Proton Pump Inhibitor-induced Hypersensitivity Reaction: A Case Report

Current awareness: Pharmacoepidemiology and drug safety

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