Repeated administration of synthetic cathinone 3,4-methylenedioxypyrovalerone persistently increases impulsive choice in rats

Hyatt, William S.; Berquist, Michael D.; Chitre, Neha Milind; Russell, Lauren; Rice, Kenner C.; Murnane, Kevin S.; Fantegrossi, William E.

doi:10.1097/fbp.0000000000000492

Cited by 7 publications

(8 citation statements)

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“…38,39 Hyatt et al ( 2019), one of the first papers to describe the effects of MDPV on impulsivity, found that acute administration of MDPV, but not cocaine, led to increases in choice impulsivity in a delay-discounting task. 40 Hyatt et al (2020) then reported that both MDPV and cocaine consistently increased impulsive action in a differential reinforcement of low rates of responding task, similar to the effects observed in the 1-CSRTT. 41 While the current study mostly aligns with the results of these papers, the increase in impulsive action after acute administration of increasing doses of each drug was not as robust, which is different from that found in previous studies.…”

Section: Discussionmentioning

confidence: 83%

“…41 While the current study mostly aligns with the results of these papers, the increase in impulsive action after acute administration of increasing doses of each drug was not as robust, which is different from that found in previous studies. 38,40,41 In addition, the amount of premature responses and food reinforcers earned decreased (and thus omissions increased) at the largest doses of cocaine and MDPV tested. Similar results were reported in Hyatt et al (2020), but operant responding suppression in the current study occurred at lower doses than what was observed in the Hyatt study.…”

Section: Discussionmentioning

confidence: 98%

“…While the number of earned reinforcers decreased as MDPV dose increased for both rat groups, the drop was less precipitous in the drug‐naïve rats. It is possible that these animals, with a history of self‐administration of either MDPV or cocaine, were sensitized to higher doses of that drug and went on to exhibit stereotypies for prolonged periods, which may explain why so many animals responded less in the 1‐CSRTT after acute administration of higher doses of drug 40 …”

Section: Discussionmentioning

confidence: 99%

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Interactions between impulsivity and MDPV self‐administration in rats

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Synthetic cathinones, such as 3,4-methylenedioxypyrovalerone (MDPV), are recreational drugs of abuse often identified in 'bath salts' preparations. Humans report compulsive patterns of bath salts use, and previous work suggests that a subset of rats develop unusually high levels of MDPV self-administration. This study aims to test the hypothesis that high levels of impulsivity (e.g., inability to withhold responding for a sucrose reward) will predispose rats to high levels of MDPV self-administration relative to rats with lower levels of impulsivity. The 1-choice serial reaction time task (1-CSRTT) was used to assess impulsivity (i.e., premature responding) in 10 female and 10 male Sprague Dawley rats. Rats were then allowed to self-administer 0.032 mg/kg/inf MDPV or 0.32 mg/kg/inf cocaine, after which full dose-response curves for MDPV (0.001-0.1 mg/kg/inf ) or cocaine (0.01-1 mg/kg/inf) were generated under a FR5 schedule of reinforcement. After a history of self-administering MDPV or cocaine, impulsivity was reassessed under the 1-CSRTT, prior to evaluating the acute effects of MDPV (0.032-0.32 mg/kg) or cocaine (0.1-1 mg/kg) on impulsivity. Level of impulsivity was not correlated with subsequent levels of either MDPV or cocaine selfadministration, and level of drug self-administration was also not correlated with subsequent levels of impulsivity, although acute administration of MDPV and cocaine did increase premature responding. In failing to find direct relationships between either impulsivity and subsequent drug-taking behaviour, or drug-taking behaviour and subsequent assessments of impulsivity, these findings highlight the complexity inherent in the associations between impulsive behaviour and drug-taking behaviour in both animal models and humans.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Interactions between impulsivity and MDPV self‐administration in rats

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“…Similarly, recent studies have shown the benefits of antiinflammatory agents for neuropsychiatric disorders [111,112]. Exposure to drugs of abuse is also known to disrupt brain dopamine systems and dopamine-related behavior [113][114][115], which may be reversible with DHA treatment. DHA and other O3FA are ligands for nuclear receptors such as the retinoid X receptor (RXR) [116].…”

Section: Neuroprotective Effects Of O3famentioning

confidence: 99%

Omega-3 Fatty Acids as Druggable Therapeutics for Neurodegenerative Disorders

Chitre

Moniri

Murnane

2020

CNSNDDT

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: Neurodegenerative disorders are commonly associated with a complex pattern of pathophysiological hallmarks, including increased oxidative stress and neuroinflammation, which makes their treatment challenging. Omega-3 Fatty Acids (O3FA) are natural products with reported neuroprotective, anti-inflammatory, and antioxidant effects. These effects have been attributed to their incorporation into neuronal membranes or through the activation of intracellular or recently discovered cell-surface receptors (i.e., Free-Fatty Acid Receptors; FFAR). Molecular docking studies have investigated the roles of O3FA as agonists of FFAR and have led to the development of receptor-specific targeted agonists for therapeutic purposes. Moreover, novel formulation strategies for targeted delivery of O3FA to the brain have supported their development as therapeutics for neurodegenerative disorders. Despite the compelling evidence of the beneficial effects of O3FA for several neuroprotective functions, they are currently only available as unregulated dietary supplements, with only a single FDA-approved prescription product, indicated for triglyceride reduction. This review highlights the relative safety and efficacy of O3FA, their drug-like properties, and their capacity to be formulated in clinically viable drug delivery systems. Interestingly, the presence of cardiac conditions such as hypertriglyceridemia is associated with brain pathophysiological hallmarks of neurodegeneration, such as neuroinflammation, thereby further suggesting potential therapeutic roles of O3FA for neurodegenerative disorders. Taken together, this review article summarizes and integrates the compelling evidence regarding the feasibility of developing O3FA and their synthetic derivatives as potential drugs for neurodegenerative disorders.

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“…The relative activation of these two systems is associated with choices in delay discounting procedures (McClure, Laibson, Loewenstein, & Cohen, 2004). Other research suggests that a range of additional biological and genetic factors can play a role in discounting rates (Anderson & Woolverton, 2005; MacKillop, 2013; Mitchell, 2004; Rung & Madden, 2018) including systemic administration of drugs of abuse (Dallery & Locey, 2005; Helms, Reeves, & Mitchell, 2006; Hyatt et al, 2019; Xue, Siemian, Johnson, Zhang, & Li, 2018). Early life adversity has also been linked to steep discounting and SUDs (Acheson, Vincent, Cohoon, & Lovallo, 2019).…”

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Delay discounting rate by a surrogate decision maker depends on the smoking status of the recipient.

Cola¹,

Dallery²

2021

Experimental and Clinical Psychopharmacology

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The tendency to devalue future rewards is known as delay discounting. Discounting is measured using a series of intertemporal choices between smaller, sooner outcomes and larger, later outcomes. We used a surrogate delay discounting task to explore whether such choices would differ if a hypothetical recipient was a smoker or was an individual with good health habits. Across three studies, the descriptions of the recipient included only information about smoking status (n ϭ 66), smoking status and equal annual income (n ϭ 47), and smoking status and equal weekly expenditures (n ϭ 42). Higher rates of delay discounting for the smoker recipient compared to the nonsmoker recipient were observed across all three studies. These results parallel previous findings showing group differences in discounting between actual smokers and nonsmokers. We discuss the similarities between the present results and previous studies in light of an extension of Bem's (1967) self-perception theory, which posits that choices in laboratorybased delay discounting tasks are informed by observation of real-world intertemporal choice. The theory asserts that there is no fundamental difference between a first-person account of such knowledge and a third-person account.

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Repeated administration of synthetic cathinone 3,4-methylenedioxypyrovalerone persistently increases impulsive choice in rats

Cited by 7 publications

References 74 publications

Interactions between impulsivity and MDPV self‐administration in rats

Interactions between impulsivity and MDPV self‐administration in rats

Omega-3 Fatty Acids as Druggable Therapeutics for Neurodegenerative Disorders

Delay discounting rate by a surrogate decision maker depends on the smoking status of the recipient.

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