Repeated administration of a selenium-containing indolyl compound attenuates behavioural alterations by streptozotocin through modulation of oxidative stress in mice

Bampi, Suely Ribeiro; Casaril, Angela Maria; Sousa, Fernanda Severo Sabedra; Pesarico, Ana Paula; Vieira, Beatriz; Lenardão, Eder J.; Savegnago, Lucielli

doi:10.1016/j.pbb.2019.06.006

Cited by 21 publications

(14 citation statements)

References 49 publications

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“…The data reviewed from animal studies in this paper provides further support for this suggestion, suggesting that both selenium and selenium-containing organic compounds were effective in reducing anxiety-like behaviours in rodents. This research also identified some of the possible molecular mechanisms underlying the anxiolytic effect of selenium, involving reduction in oxidative stress [49,50,54,53,56], reductions in the levels of pro-inflammatory cytokines [51], normalization of stress-induced changes in hypothalamic-pituitary-adrenal axis functioning [45,53], interactions with neurotransmitters such as serotonin, glutamate and GABA [43-46, 48, 49, 52], and alterations in thyroid functioning [46]. However, these results should be interpreted with caution for the following reasons.…”

Section: Discussionmentioning

confidence: 99%

“…Sixteen of the papers included in this review belonged to this category [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57]. Methodological details and results for each of these studies are summarized in Table 1.…”

Section: Selenium Selenoproteins and Selenium-containing Compounds In...mentioning

confidence: 99%

“…Methodological details and results for each of these studies are summarized in Table 1. Fourteen studies examined the effects of selenium or selenium compounds on animal models of anxiety [43][44][45][46][47][48][49][50][51][52][53][54][55][56]. Of these studies, the majority (n = 10) used organic seleniumcontaining compounds as interventions, while two used elemental selenium and two used sodium selenite.…”

Section: Selenium Selenoproteins and Selenium-containing Compounds In...mentioning

confidence: 99%

“…Various procedures were used for the induction of anxiety in experimental animals. In seven studies, anxiety was induced by the administration of a drug or toxin: these included lipopolysaccharide (LPS) (n = 2), streptozotocin (n = 2), corticosterone, kainate and arsenic (n = 1 each) [45,48,50,51,[54][55][56]. In two studies, anxiety was induced by subjecting animals to acute restraint [49,53].…”

Section: Selenium Selenoproteins and Selenium-containing Compounds In...mentioning

confidence: 99%

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Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Rajkumar¹

2022

Preprint

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Anxiety disorders are among the most common mental disorders worldwide, and often respond incompletely to existing treatments. Selenium, a micronutrient that is a component of several biologically active selenoproteins, is also involved in several aspects of brain functioning, and may exert antidepressant and anxiolytic effects through multiple pathways. The current paper is a scoping review of translational, observational and interventional evidence on the potential role of selenium and its compounds in the management of anxiety and related disorders. Evidence from animal models suggests that this approach may be promising. Though evidence from observational studies in humans is inconsistent and affected by several confounding factors, the available evidence from randomized controlled trials suggests that selenium supplementation may be beneficial in the management of certain anxiety-related conditions, such as anxiety in medically ill patients, prevention of anxiety following exposure to traumatic stress, and obsessive-compulsive disorder. This paper provides a critical evaluation of the existing evidence base, including unanswered questions that could serve as the focus of further research, and outlines the potential benefits and risks associated with the use of selenium in anxiety disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Selenium Selenoproteins and Selenium-containing Compounds In...mentioning

confidence: 99%

Section: Selenium Selenoproteins and Selenium-containing Compounds In...mentioning

confidence: 99%

Section: Selenium Selenoproteins and Selenium-containing Compounds In...mentioning

confidence: 99%

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Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Rajkumar¹

2022

Preprint

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“…86,87 It is also found that another strong antioxidant, Zinc, has shown its antidepressant activity. 88 Moreover, some literature has supported that several micronutrients including zinc, 89 magnesium 90 and selenium 91 are relevant to the oxidative stress. Therefore, future…”

Section: Antioxidation System and Nitric Oxiderelated Antidepressanmentioning

confidence: 99%

Curcumin in antidepressant treatments: An overview of potential mechanisms, pre‐clinical/clinical trials and ongoing challenges

Zhang

2020

Basic Clin Pharma Tox

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Depression is one of the most common but serious psychiatric disorders affecting millions of people globally, which has become increasingly prevalent during the past few decades. To alleviate this challenging health and social burden, various therapeutic strategies have been developed to achieve efficient treatments for depression. In particular, plenty of chemical ingredients of natural origin have been investigated as new direct antidepressants or served as adjuvants to improve the current treatment outcomes of existing antidepressant drugs. Among them, curcumin, a natural compound derived from the herb Curcuma longa, exhibits a wide range of pharmacological properties and has been considered a potent antidepressant drug with diverse mechanisms including monoaminergic imbalances (associated with serotonin, dopamine, noradrenaline and glutamate), effect on neurotransmitters, neuroprogression, the hypothalamic‐pituitary‐adrenal (HPA) axis disturbances, dysregulated inflammation and immune pathways, oxidative and nitrosative stress, and mitochondrial disturbances. In this review, multiple potential mechanisms of curcumin for treating depression demonstrated in either animal or human studies are summarized. To better understand the significant role of curcumin, specific emphasis will be placed on the aetiopathogenesis of depression. Finally, current pre‐clinical/clinical trials and ongoing challenges of curcumin used for antidepressant treatments will be discussed and their future outlooks will be briefly presented.

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Toxicology and pharmacology of synthetic organoselenium compounds: an update

2021

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Here, we addressed the pharmacology and toxicology of synthetic organoselenium compounds and some naturally occurring organoselenium amino acids. The use of selenium as a tool in organic synthesis and as a pharmacological agent goes back to the middle of the nineteenth and the beginning of the twentieth centuries. The rediscovery of ebselen and its investigation in clinical trials have motivated the search for new organoselenium molecules with pharmacological properties. Although ebselen and diselenides have some overlapping pharmacological properties, their molecular targets are not identical. However, they have similar anti-inflammatory and antioxidant activities, possibly, via activation of transcription factors, regulating the expression of antioxidant genes. In short, our knowledge about the pharmacological properties of simple organoselenium compounds is still elusive. However, contrary to our early expectations that they could imitate selenoproteins, organoselenium compounds seem to have non-specific modulatory activation of antioxidant pathways and specific inhibitory effects in some thiol-containing proteins. The thiol-oxidizing properties of organoselenium compounds are considered the molecular basis of their chronic toxicity; however, the acute use of organoselenium compounds as inhibitors of specific thiol-containing enzymes can be of therapeutic significance. In summary, the outcomes of the clinical trials of ebselen as a mimetic of lithium or as an inhibitor of SARS-CoV-2 proteases will be important to the field of organoselenium synthesis. The development of computational techniques that could predict rational modifications in the structure of organoselenium compounds to increase their specificity is required to construct a library of thiol-modifying agents with selectivity toward specific target proteins.

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Repeated administration of a selenium-containing indolyl compound attenuates behavioural alterations by streptozotocin through modulation of oxidative stress in mice

Cited by 21 publications

References 49 publications

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

Curcumin in antidepressant treatments: An overview of potential mechanisms, pre‐clinical/clinical trials and ongoing challenges

Toxicology and pharmacology of synthetic organoselenium compounds: an update

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