Abstract:5-Hydroxytryptamine 2C (5-HT ) receptor agonists have been suggested to possess an antipsychotic activity in several acute preclinical tests of antipsychotic drugs with low extra-pyramidal side effect liability. However, little is known about the long-term effect associated with chronic use of 5-HT receptor agonists. The present study examined whether repeated activation of 5-HT receptor with a highly selective 5-HT receptor agonist MK212 would induce a long-term change in its antipsychotic-like activity (eith… Show more
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