Repeated Activation of Gαq by neurotransmitters causes age-dependent accumulation of stress granules inC.elegans
Madison Rennie,
Suzanne Scarlata
Abstract:Gαq proteins mediate signals from neurotransmitters to transduce calcium signals. In PC12 cells, we have shown that Gαq stimulation results in retraction of neurites and induces the formation of stress granules that sequester two specific mRNAs,ChbgbandATP5f1b. Here, we show that repeated activation of Gαq inC. elegansadversely reduces lifespan potentially through accumulation of stress granules and inefficient recovery from neurite retraction. In the absence of stimulation, we could not detect significant cha… Show more
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