Repeatability of the measurement of augmentation index in the clinical assessment of arterial stiffness using radial applanation tonometry

Crilly, Michael A; Coch, Christoph; Clark, Hazel J; Bruce, Margaret; Williams, David

doi:10.1080/00365510601131946

Cited by 24 publications

(13 citation statements)

References 19 publications

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“…Two measurements meeting manufacturer‐defined quality control values were averaged. This technique has demonstrated satisfactory inter‐ and intra‐operator reproducibility in previous studies …”

Section: Methodsmentioning

confidence: 70%

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Pilot study of the effects of bariatric surgery and continuous positive airway pressure treatment on vascular function in obese subjects with obstructive sleep apnoea

Bakker

Balachandran

Tecilazich

et al. 2013

Internal Medicine Journal

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The mechanisms by which obesity and obstructive sleep apnoea (OSA) may contribute to endothelial dysfunction are unclear.\ud \ud AIMS:\ud We sought to follow up a sample of obese subjects undergoing either bariatric surgery or continuous positive airway pressure (CPAP) therapy to treat OSA. We hypothesised improved vascular function with both therapeutic approaches, consistent with a reversible OSA effect on the circulation.\ud \ud METHODS:\ud Twenty-seven obese (BMI ≥30 kg/m(2)) subjects with OSA underwent either bariatric surgery without CPAP (n = 12, median BMI 43.7 kg/m(2) IQR 9.4) or CPAP (n = 15, median BMI 33.8 kg/m(2) IQR 6.6). Polysomnography and vascular testing (flow-mediated dilation of the brachial artery measured with high-resolution ultrasound, endothelium-dependent change in skin blood flow measured with laser Doppler flowmetry, and arterial stiffness measured with applanation tonometry) took place at baseline and after 6 months.\ud \ud RESULTS:\ud Both groups showed significant improvements in the apnoea-hypopnea index and overnight oxygen saturation. Endothelium-dependent microvascular reactivity was 45.6% (IQR 37.5) at baseline in the CPAP group, which increased to 69.1% (IQR 62.3) post-treatment (P < 0.05). No significant changes were observed in the surgery group, despite significant weight loss (post-surgery BMI 32.7 kg/m2 IQR 8.6 (P < 0.01); no change in BMI was observed in the CPAP group. There were no significant changes in brachial artery flow-mediated dilation in either group.\ud \ud CONCLUSIONS:\ud This pilot study demonstrates that 6 months of CPAP may be sufficient to improve endothelium-dependent microvascular reactivity, while substantial surgically induced weight loss did not result in improvements. Further research should be directed towards comparative effectiveness trials using these novel surrogate outcomes, as well as hard cardiovascular outcomes

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Section: Methodsmentioning

confidence: 70%

“…This technique has demonstrated satisfactory inter-and intra-operator reproducibility in previous studies. 25,26…”

Section: Assessment Of Blood Pressure and Arterial Stiffnessmentioning

confidence: 99%

Pilot study of the effects of bariatric surgery and continuous positive airway pressure treatment on vascular function in obese subjects with obstructive sleep apnoea

Bakker

Balachandran

Tecilazich

et al. 2013

Internal Medicine Journal

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“…Two observers measured pulse waves sequentially using the same probe types for the analysis of inter-observer reproducibility. To assess intra-observer reproducibility, the pulse wave was measured three times, in the radial artery only, by the same observer, with no interval between the measurements (Chen et al, 1997;Crilly et al, 2007b). Stability is the ability of a sensor to maintain its performance parameters for a period of time.…”

Section: Protocolmentioning

confidence: 99%

Quantitative Comparison of the Performance of Piezoresistive, Piezoelectric, Acceleration, and Optical Pulse Wave Sensors

Wang

Sun

et al. 2020

Front. Physiol.

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“…Applanation tonometry has previously been established as highly reproducible (intra-and inter-operator) in healthy as well as diseased populations. 12,13 PWV measurements were performed in duplicate and averaged for statistical analyses. Reported values are mean AE standard deviation (SD).…”

Section: Arterial Stiffness and Haemodynamic Measurementsmentioning

confidence: 99%

Carotid Endarterectomy Improves Peripheral but not Central Arterial Stiffness

Gorgui

Doonan

Gomez

et al. 2013

European Journal of Vascular and Endovascular Surgery

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We assessed, for the first time, the short-term effect of CEA on arterial stiffness and haemodynamics. CEA improved peripheral but not central arterial stiffness. This study provides evidence for significant changes in certain arterial stiffness and haemodynamic parameters. Longer-term follow-up will assess whether these changes are sustained and whether CEA is associated with further haemodynamic benefits.

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Repeatability of the measurement of augmentation index in the clinical assessment of arterial stiffness using radial applanation tonometry

Abstract: Even when undertaken by relatively inexperienced operators, both 'within' and 'between' observer repeatability of AIx measurement is very high. Such non-invasive assessment of arterial stiffness has the potential to be included in the clinical assessment of ambulant patients.

Cited by 24 publications

References 19 publications

Pilot study of the effects of bariatric surgery and continuous positive airway pressure treatment on vascular function in obese subjects with obstructive sleep apnoea

Pilot study of the effects of bariatric surgery and continuous positive airway pressure treatment on vascular function in obese subjects with obstructive sleep apnoea

Quantitative Comparison of the Performance of Piezoresistive, Piezoelectric, Acceleration, and Optical Pulse Wave Sensors

Carotid Endarterectomy Improves Peripheral but not Central Arterial Stiffness

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