Abstract:Objectives: To describe the short-and medium-term repeatability of lung clearance index at 2.5% (LCI 2.5 ) in infants and calculate the number of patients needed to enroll in a study (N) using LCI 2.5 as a primary outcome.Methods: An 8-month follow-up observational study was employed for assessing short-term [coefficient of repeatability (CR) and intraclass correlation (ICC)] and medium-term repeatability (Bland-Altman method) of LCI 2.5 in infants with cystic fibrosis (CF) or recurrent wheeze (RW) measured by… Show more
“…To be able to utilize N 2 ‐MBW as a tool to monitor lung disease, data on the variability of this measurement are needed. Koucky et al 9 performed serial N 2 ‐MBW in a cohort of infants with CF and recurrent wheezing and established short‐term and medium‐term variability of in LCI. These data will be helpful in planning future studies.…”
“…To be able to utilize N 2 ‐MBW as a tool to monitor lung disease, data on the variability of this measurement are needed. Koucky et al 9 performed serial N 2 ‐MBW in a cohort of infants with CF and recurrent wheezing and established short‐term and medium‐term variability of in LCI. These data will be helpful in planning future studies.…”
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