Repeatability of Computerized Tomography–Based Anthropomorphic Measurements of Frailty in Patients With Pulmonary Fibrosis Undergoing Lung Transplantation

McClellan, Taylor R; Allen, Brian C.; Kappus, Matthew R.; Bhatti, Lubna; Dafalla, R; Snyder, Laurie D.; Bashir, Mustafa R.

doi:10.1067/j.cpradiol.2016.12.009

Cited by 12 publications

(3 citation statements)

References 32 publications

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“…Primary analyses were performed using areas at L4/L5, with sensitivity analyses performed at L3/L4. 20,25 All tissue within the peritoneal cavity with the density of adipose tissue was identified as VAT. All tissue with the density of adipose and located outside of the peritoneal cavity but not within the muscle was identified as SAT.…”

Section: Pericardial Adipose Tissue Volumementioning

confidence: 99%

Adiposity and Interstitial Lung Abnormalities in Community-Dwelling Adults

Anderson

Kim

Allison

et al. 2021

Chest

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Section: Pericardial Adipose Tissue Volumementioning

confidence: 99%

Adiposity and Interstitial Lung Abnormalities in Community-Dwelling Adults

Anderson

Kim

Allison

et al. 2021

Chest

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“…Generally, multireader studies are preferred; however, we did not feel this was necessary based on very strong interreader reliability of our measurement technique established in prior studies. ( 33‐36 ) In vivo precision errors for muscle mass measurements have been reported but are low due to high‐resolution imaging (≤50 μm). ( 35 )…”

Section: Discussionmentioning

confidence: 99%

Use of Skeletal Muscle Index as a Predictor of Wait‐List Mortality in Patients With End‐Stage Liver Disease

Kappus

Wegermann

Bozdogan³

et al. 2020

Liver Transpl

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The aim of this study is to validate a proposed definition of sarcopenia in predicting wait‐list mortality. We retrospectively evaluated 355 adults (age ≥18 years) with cirrhosis listed for first‐time LT from January 1, 2010, to April 1, 2018 from our center. Demographic, laboratory, and outcome data were collected in conjunction with computed tomography scans performed within 3 months of listing. Using imaging analysis software, the skeletal muscle index (SMI), which is a marker for sarcopenia‐related mortality, was calculated. A survival analysis was performed to evaluate the association of the proposed sarcopenia definition of SMI <50 cm2/m2 for men or <39 cm2/m2 for women with wait‐list mortality or delisting. Median SMI was 54.1 cm2/m2 (range, 47‐60 cm2/m2). A total of 61 (17.2%) patients exhibited sarcopenia according to the proposed threshold, and 24.6% (57/232) of men were sarcopenic compared with 3.3% (4/123) of women (P < 0.001). Mean (standard deviation [SD]) SMI was also higher for men (56.6 ± 9.6 cm2/m2) than for women (50.7 ± 8.0 cm2/m2; P < 0.001). Median follow‐up time among patients was 2.1 months (0‐12 months), and 30 events were observed (hazard ratio, 0.98; 95% confidence interval, 0.95‐1.02; P = 0.41). There was no statistically significant difference in time on the waiting list between patients with and without sarcopenia (P = 0.89) as defined at the threshold. Using the prespecified definitions of sarcopenia based on SMI, there was no statistically significant difference in mortality and delisting from the transplant waiting list between patients with and without sarcopenia in this population. Practice and region‐specific patterns for pretransplant selection and median Model for End‐Stage Liver Disease at transplant may affect SMI as a predictor of wait‐list mortality.

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“…Reports utilizing the sarcopenia criteria in ILD have been limited ( 82 , 84 ). Skeletal muscle mass in ILD has often been quantified using the cross-sectional area of thoraco-abdominal muscles measured from computed tomography (CT) ( 90 ). Studies have shown that decreased cross-sectional areas of erector spinae muscles (ESMCSA) ( 91 , 92 ) and pectoralis muscles (PM CSA) ( 62 , 93 ) measured with CT images were associated with lower skeletal muscle mass index, decreased quadriceps strength, increased ILD severity ( 11 , 93 - 95 ) and mortality ( 93 ).…”

Section: Main Findings—physical and Cognitive Limitations In Ild Pati...mentioning

confidence: 99%

The interplay of physical and cognitive function in rehabilitation of interstitial lung disease patients: a narrative review

Hanada,

Tanaka,

Kozu

et al. 2023

J Thorac Dis

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Background and Objective Interstitial lung disease (ILD) encompasses several diverse pulmonary pathologies that result in abnormal diffuse parenchymal changes. When prescribing rehabilitation, several additional factors need to be considered as a result of aging, polypharmacy, and comorbidities manifested in ILD patients. This review aims to discuss issues related to frailty, skeletal muscle and cognitive function that limit physical activities in ILD patients. It will also highlight exercise training and propose complementary strategies for pulmonary rehabilitation. Methods A literature search was performed in MEDLINE, CINAHL (inception to October 19th, 2022) using search terms based on concepts of: idiopathic pulmonary fibrosis or interstitial lung disease; frailty; muscular atrophy; skeletal muscle dysfunction; cognitive dysfunction; sleep quality; sleep disorders; anxiety disorders; or depressive disorders. After eligible texts were screened, additional references were included from references cited in the screened articles. Key Content and Findings Frailty and skeletal muscle dysfunction are common in ILD. Weight loss, exhaustion, and anti-fibrotic medications can impact frailty, whereas physical inactivity, aging, corticosteroids and hypoxemia can contribute to sarcopenia (loss of muscle mass and function). Frailty is associated with worse clinical status, exercise intolerance, skeletal muscle dysfunction, and decreased quality of life in ILD. Sarcopenia appears to influence wellbeing and can potentially affect overall physical conditioning, cognitive function and the progression of ILD. Optimal assessment tools and effective strategies to prevent and counter frailty and sarcopenia need to be determined in ILD patients. Even though cognitive impairment is evident in ILD, its prevalence and underlying neurobiological model of contributing factors (i.e., inflammation, disease severity, cardiopulmonary status) requires further investigation. How ILD affects cognitive interference, motor control and consequently physical daily activities is not well defined. Strategies such as pulmonary rehabilitation, which primarily focuses on strength and aerobic conditioning have demonstrated improvements in ILD patient outcomes. Future incorporation of interval training and the integration of motor learning could improve transfer of rehabilitation strategies to daily activities. Conclusions Numerous underlying etiologies of ILD contribute to frailty, skeletal muscle and cognitive function, but their respective neurobiologic mechanisms require further investigation. Exercise training increases physical measures, but complementary approaches may improve their applicability to improve daily activities.

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Repeatability of Computerized Tomography–Based Anthropomorphic Measurements of Frailty in Patients With Pulmonary Fibrosis Undergoing Lung Transplantation

Cited by 12 publications

References 32 publications

Adiposity and Interstitial Lung Abnormalities in Community-Dwelling Adults

Adiposity and Interstitial Lung Abnormalities in Community-Dwelling Adults

Use of Skeletal Muscle Index as a Predictor of Wait‐List Mortality in Patients With End‐Stage Liver Disease

The interplay of physical and cognitive function in rehabilitation of interstitial lung disease patients: a narrative review

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