Repeatability and reproducibility of retinal nerve fibre layer thickness measurements with the iVue-100 optical coherence tomographer

Abstract

BackgroundAccurate and repeatable measurements of the retinal nerve fibre layer (RNFL) thickness are important in the diagnosis and management of glaucoma and other disorders.ObjectiveTo assess the repeatability and reproducibility of the iVue-100 optical coherence tomographer (OCT).MethodsThe thickness of the RNFL was measured for 50 healthy participants using the iVue-100 OCT. Although both eyes per participant were measured, only right eyes were analysed here. Repeatability and reproducibility of the iVue-100 OCT were assessed using the intraclass correlation coefficient (ICC), coefficient of variation (CoV), paired t-tests and Bland-Altman analysis.ResultsGood intra-observer repeatability was obtained as indicated by the ICC of observer 1 (range: 0.941 – 0.976) and observer 2 (range: 0.829 – 0.953) as well by the CoV of observer 1 (range: 0.098 – 0.137) and observer 2 (0.091 – 0.132). In terms of inter-observer reproducibility, significant differences (p< 0.05) in mean measurements between the observers were noted for the average RNFL readings and in the superior and inferior quadrants as assessed with paired t-tests. Even though significant inter-session differences were found for the average RNFL thickness and the superior quadrant (p = 0.003 and p = 0.013, respectively), excellent ICCs were obtained for inter-session reproducibility (range: 0.914 – 0.979).ConclusionThe iVue-100 OCT demonstrated good repeatability and reproducibility for RNFL thickness measurements.

Sexuality and other issues in Africa and beyond

“…The work by Jibrin and others11 highlights the histo-pathological pattern of brain tumours in Nigeria. The rest of the NCD papers, deal with diagnosis of ischemic disease12, rheumatoid arthritis13, the retina14, hearing loss15, limb injury16, poisoning17, and glaucoma 18…”