Repeat semen analysis – an unnecessary delay in urologic evaluation?

Ursillo, Lauren; Yeshua, Arielle; Mullin, Christine; Hershlag, Avner; Shan, Weiwei; Abittan, Baruch; Girardi, Sarah K.; Goldman, Randi H.

doi:10.1016/j.fertnstert.2019.07.1042

Cited by 1 publication

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“…There were only three occasions where a participant returned an abnormal semen parameter in their first collection and then normal results on subsequent collections. These results align with that of Ursillo et al [ 29 ], who also showed concordance in their second semen collection in approximately 75% of patients who returned an abnormal semen parameter (i.e. count and motility) on first collection.…”

Section: Discussionsupporting

confidence: 91%

The influence of lifestyle and biological factors on semen variability

Lyons,

Gyawali,

Mathews

et al. 2024

J Assist Reprod Genet

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Purpose Semen parameters are subjected to within-individual variability over time. The driving factors for this variability are likely multi-factorial, with healthier lifestyle associated with better semen quality. The extent in which variations in individual’s lifestyle contributes to within-individual semen variability is unknown. Methods A total of 116 repeat semen samples from 29 men aged 19–37 over 6 months were collected. Basic semen analysis as per 5th WHO manual and extended semen parameters (sperm DNA fragmentation, redox potential and lipid peroxidation, sperm binding to hyaluronan and hyperactive motility) were assessed. An additional 39 lifestyle/biological factors (weight, blood pressure, etc.) were collected at each sample including validated health questionnaires SF36 Health Status, Australian Recommend Food Score, and International Physical Activity Questionnaire. Results Only 10 out of the 39 lifestyle factors varied within men across samples including age (P = 0.0024), systolic blood pressure (P = 0.0080), social functioning (P = 0.0340), energy (P = 0.0069), non-alcoholic caffeinated beverages (P = 0.0010), and nutrition (P < 0.0001). The only semen parameter that varied between collections was sperm morphology (coefficient of variation 23.8 (6.1–72.0), P < 0.05). We only observed weak (r < 0.3) to moderate (r > 0.3– < 0.6) correlations between lifestyle factors, including body mass index, waist circumference, nutrition, exercise, blood pressure and semen parameters including sperm count, progressive motility, and sperm DNA fragmentation (P < 0.05). Conclusion In healthy men from the general population, semen quality and associated lifestyle factors do not significantly vary over 6 months, indicating that one semen sample is likely sufficient for determining male fertility in this population.

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Section: Discussionsupporting

confidence: 91%