Repeat Screening Outcomes with Digital Breast Tomosynthesis Plus                    Synthetic Mammography for Breast Cancer Detection: Results from the Prospective                    Verona Pilot Study

Caumo, Francesca; Montemezzi, Stefania; Romanucci, Giovanna; Brunelli, S.; Bricolo, Paola; Cugola, L; Gennaro, Gisella

doi:10.1148/radiol.2020201246

Cited by 15 publications

(6 citation statements)

References 30 publications

(17 reference statements)

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“…Few studies report results from consecutive screening rounds after screening with DBT -however, following the women in the next screening round is one way to understand this issue. In the Verona study (207), half of the women screened in the consecutive round after DBT+SM were screened with DBT+SM and half with DM. The cancer detection rate at baseline screening with DBT+SM was 9.3/1000, whereas the cancer detection rates at consecutive screening were 8.1/1000 (DBT+SM) and 3.5/1000 (DM).…”

Section: Screening With Dbtmentioning

confidence: 99%

True and Missed Interval Cancer in Organized Mammographic Screening: A Retrospective Review Study of Diagnostic and Prior Screening Mammograms

et al. 2022

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Section: Screening With Dbtmentioning

confidence: 99%

True and Missed Interval Cancer in Organized Mammographic Screening: A Retrospective Review Study of Diagnostic and Prior Screening Mammograms

et al. 2022

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“…The additional role of tomosynthesis in asymptomatic patients with predominantly dense breasts in screening examinations has been well investigated with encouraging results. DBT has demonstrated an increased cancer detection rate of 2.2 to 2.5 per 1000 screenings [5][6][7][8]. However, one of the main problems associated with the use of tomosynthesis in a screening setting is a non-negligible average glandular dose to which patients are subjected [29].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have introduced Digital Breast Tomosynthesis (DBT) in mammography screening, especially in high-risk patients with dense breasts [5][6][7]. Those studies found increased cancer detection rates with DBT, from 1.9 to 4.1 per 1000 women screened with recall rates lower than or comparable to those with DM, and an increased cancer detection rate of up to 30-40% [8].…”

Section: Introductionmentioning

confidence: 99%

Breast Digital Tomosynthesis versus Contrast-Enhanced Mammography: Comparison of Diagnostic Application and Radiation Dose in a Screening Setting

Nicosia

Bozzini

Pesapane

et al. 2023

Cancers

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This study aims to evaluate the Average Glandular Dose (AGD) and diagnostic performance of CEM versus Digital Mammography (DM) as well as versus DM plus one-view Digital Breast Tomosynthesis (DBT), which were performed in the same patients at short intervals of time. A preventive screening examination in high-risk asymptomatic patients between 2020 and 2022 was performed with two-view Digital Mammography (DM) projections (Cranio Caudal and Medio Lateral) plus one Digital Breast Tomosynthesis (DBT) projection (mediolateral oblique, MLO) in a single session examination. For all patients in whom we found a suspicious lesion by using DM + DBT, we performed (within two weeks) a CEM examination. AGD and compression force were compared between the diagnostic methods. All lesions identified by DM + DBT were biopsied; then, we assessed whether lesions found by DBT were also highlighted by DM alone and/or by CEM. We enrolled 49 patients with 49 lesions in the study. The median AGD was lower for DM alone than for CEM (3.41 mGy vs. 4.24 mGy, p = 0.015). The AGD for CEM was significantly lower than for the DM plus one single projection DBT protocol (4.24 mGy vs. 5.55 mGy, p < 0.001). We did not find a statistically significant difference in the median compression force between the CEM and DM + DBT. DM + DBT allows the identification of one more invasive neoplasm one in situ lesion and two high-risk lesions, compared to DM alone. The CEM, compared to DM + DBT, failed to identify only one of the high-risk lesions. According to these results, CEM could be used in the screening of asymptomatic high-risk patients.

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“…In recent years there has been consistent evidence that synthesized mammography (synt2D) in place of conventional mammography in screening and symptomatic settings is at least the equal of standard 2D digital mammography in the detection of malignancy [6][7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Lobular Breast Cancer Conspicuity on Digital Breast Tomosynthesis Compared to Synthesized 2D Mammography: A Multireader Study

Romanucci¹,

Zantedeschi²,

Ventriglia³

et al. 2021

J. Imaging

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Objectives: To compare the conspicuity of lobular breast cancers at digital breast tomosynthesis (DBT) versus synthesized 2D mammography (synt2D). Materials and methods: Seventy-six women (mean age 61.2 years, range 50–74 years) submitted to biopsy in our institution, from 2019 to 2021, with proven invasive lobular breast cancer (ILC) were enrolled in this retrospective study. The participants underwent DBT and synt2D. Five breast radiologists, with different years of experience in breast imaging, independently assigned a conspicuity score (ordinal 6-point scale) to DBT and synt2D. Lesion conspicuity was compared, for each reader, between the synt2D overall conspicuity interpretation and DBT overall conspicuity interpretation using a Wilcoxon matched pairs test. Results: A total of 50/78 (64%) cancers were detected on both synt2D and DBT by all the readers, while 28/78 (26%) cancers where not recognized by at least one reader on synt2D. For each reader, in comparison with synt2D, DBT increased significantly the conspicuity of ILC (p < 0.0001). The raw proportion of high versus low conspicuity by modality confirmed that cancers were more likely to have high conspicuity at DBT than synt2D. Conclusions: ILCs were more likely to have high conspicuity at DBT than at synt2D, increasing the chances of the detection of ILC breast cancer.

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Repeat Screening Outcomes with Digital Breast Tomosynthesis Plus Synthetic Mammography for Breast Cancer Detection: Results from the Prospective Verona Pilot Study

Cited by 15 publications

References 30 publications

True and Missed Interval Cancer in Organized Mammographic Screening: A Retrospective Review Study of Diagnostic and Prior Screening Mammograms

True and Missed Interval Cancer in Organized Mammographic Screening: A Retrospective Review Study of Diagnostic and Prior Screening Mammograms

Breast Digital Tomosynthesis versus Contrast-Enhanced Mammography: Comparison of Diagnostic Application and Radiation Dose in a Screening Setting

Lobular Breast Cancer Conspicuity on Digital Breast Tomosynthesis Compared to Synthesized 2D Mammography: A Multireader Study

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