Repeat measurements of uterine artery pulsatility index, mean arterial pressure and serum placental growth factor at 12, 22 and 32 weeks in prediction of pre‐eclampsia

Andrietti, Silvia; Carlucci, Stefania; Wright, Alan; Wright, Dave; Nicolaides, Kypros H.

doi:10.1002/uog.17403

Cited by 22 publications

(22 citation statements)

References 28 publications

(47 reference statements)

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“…The subsequent fall in UtA‐PI with advancing gestation is thought to result from decreasing impedance to the uterine blood flow as trophoblast invasion is eventually completed. However, we, and others, have demonstrated that there is a de‐novo increase in third‐trimester UtA‐PI in pregnancies that are at increased risk of HDP. Furthermore, de‐novo increase in UtA‐PI in the third trimester is also associated with FGR, stillbirth and adverse clinical outcomes, even in the absence of HDP.…”

Section: Introductionmentioning

confidence: 70%

Correlation between central and uterine hemodynamics in hypertensive disorders of pregnancy

Perry

Lehmann

Mantovani

et al. 2019

Ultrasound in Obstet & Gyne

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Differences observed in the uterine artery resistance in the third trimester of pregnancy are mirrored in the central maternal haemodynamic parameters. Late pregnancy differences in the utero-placental circulation in preterm and term HDP are an index of maternal cardiovascular function rather than being related to inadequate spiral artery modelling and impaired placentation. This article is protected by copyright. All rights reserved.

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Section: Introductionmentioning

confidence: 70%

Correlation between central and uterine hemodynamics in hypertensive disorders of pregnancy

Perry

Lehmann

Mantovani

et al. 2019

Ultrasound in Obstet & Gyne

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“…Ocular Doppler assessments are also more amenable to use in an office setting rather than requiring a scheduled exam with an ultrasound technician. The latter is of particular relevance when considering the increasing utility of repeat and third‐trimester measurement of maternal hemodynamic assessment in later pregnancy in screening and diagnosis of PE. There is no study combining serum biomarkers with ophthalmic artery Doppler for the prediction of PE; however, given similar performance to uterine artery Doppler screening, it might be safe to expect equal effectiveness in combined Doppler/biochemical screening for PE.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic artery Doppler for prediction of pre‐eclampsia: systematic review and meta‐analysis

Kalafat

Laoreti

Khalil

et al. 2018

Ultrasound in Obstet & Gyne

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Ophthalmic artery Doppler is a simple, accurate and objective technique with a standalone predictive value for the development of early-onset PE equivalent to that of uterine artery Doppler evaluation. The relationship between ophthalmic Doppler indices and PE cannot be a consequence of trophoblast invasion and may be related to maternal hemodynamic adaptation to pregnancy. The findings of this review justify efforts to elucidate the effectiveness and underlying mechanism whereby two seemingly unrelated maternal vessels can be used for the prediction of a disease considered a 'placental disorder'. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

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“…The mechanisms linking low maternal circulating PlGF levels with decreases in cord blood IGF-I and leptin levels are unclear. Low maternal PlGF levels are associated with placental insufficiency as indicated by Doppler measurement of uterine artery pulsatility index ( 24 – 26 ). Low maternal PlGF levels may be indicative of placental insufficiency with reduced nutrient transfer and oxygen supply across the placenta ( 4 ).…”

Section: Discussionmentioning

confidence: 99%

Maternal Circulating Placental Growth Factor and Neonatal Metabolic Health Biomarkers in Small for Gestational Age Infants

Nuyt

Luo

et al. 2018

Front. Endocrinol.

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Small for gestational age (SGA) infants are at increased risk of type 2 diabetes in adulthood. It is unknown whether any prenatal biomarkers are helpful for identifying SGA infants with altered metabolic health profile at birth or later life. In a nested study of 162 SGA (birth weight < 10th percentile) and 161 optimal birth weight (25th–75th percentiles) control infants in the 3D (design, develop and discover) birth cohort in Canada, we assessed whether maternal circulating placental growth factor (PlGF), a biomarker of placental function, is associated with metabolic health biomarkers in SGA infants. Main outcomes were cord plasma insulin, proinsulin, insulin-like growth factor-I (IGF-I), leptin, and high-molecular weight (HMW) adiponectin concentrations. Maternal PlGF concentrations at 32–35 weeks of gestation were substantially lower in SGA versus control infants (P < 0.001), so as were cord plasma proinsulin (P = 0.005), IGF-I (P < 0.001), leptin (P < 0.001), and HMW adiponectin (P = 0.002) concentrations. In SGA infants with both low (<25th percentile) and normal maternal PlGF concentrations, cord plasma IGF-I and leptin concentrations were lower than control infants, but the decreases were to a greater extent in SGA infants with low maternal PlGF. Cord blood leptin levels were lower comparing SGA infants with low vs. normal maternal PlGF levels (P = 0.01). SGA infants with low maternal circulating PlGF levels at late gestation were characterized by greater decreases in cord blood IGF-I and leptin concentrations. Maternal circulating PlGF appears to be associated with neonatal metabolic health profile in SGA infants.

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Repeat measurements of uterine artery pulsatility index, mean arterial pressure and serum placental growth factor at 12, 22 and 32 weeks in prediction of pre‐eclampsia

Abstract: Objective

Cited by 22 publications

References 28 publications

Correlation between central and uterine hemodynamics in hypertensive disorders of pregnancy

Correlation between central and uterine hemodynamics in hypertensive disorders of pregnancy

Ophthalmic artery Doppler for prediction of pre‐eclampsia: systematic review and meta‐analysis

Maternal Circulating Placental Growth Factor and Neonatal Metabolic Health Biomarkers in Small for Gestational Age Infants

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