Repeat liver resection for colorectal metastases

Kulik, Ulf; Bektaş, H.; Klempnauer, Jürgen; Lehner, Frank

doi:10.1002/bjs.9132

Cited by 54 publications

(33 citation statements)

References 24 publications

(33 reference statements)

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“…[13][14][15][16] In the patients with relapse after the initial hepatic resection, the recurrences were distributed relatively equally among the liver, lung, and liver and lung concurrently, 3 and patients with pulmonary or pulmonary with hepatic recurrence had poorer prognoses than those with isolated intrahepatic recurrence, as reported previously by our colleagues. 7 It remains unclear whether sequential operative management for successive recurrences provides survival benefit after relapse.…”

supporting

confidence: 61%

“…At each of the repeat resections with curative intent, approximately one-third of the patients remained recurrence-free, and two-thirds developed recurrence events; of the latter, onehalf were found to be suitable candidates for further resection. Compared with previous studies in which repeated resections were carried out for selected recurrences in the liver or lung (Supplementary Table I, online version only), [13][14][15][16]21 our results provide the following additional clinically beneficial information: (1) the outcomes of sequential resections for successive recurrences, namely, natural history in the patients who underwent upfront curative hepatic resection; (2) the actual benefit of the repeat resection itself without perioperative intervention (ie, systemic chemotherapy, ablation therapy, or hepatic arterial infusion therapy) as the second, third, and fourth lines of treatment; and (3) data from a sufficient number of patients treated according to the same therapeutic policy for CLM and followed for a sufficient duration of time at a single specialized center. The recent report by Saiura et al 21 also lends support to the potentially curative role of repeat resection, especially for a first recurrence in the liver or lung alone after the initial liver resection for CLM.…”

Section: Discussionmentioning

confidence: 94%

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Survival benefit of repeat resection of successive recurrences after the initial hepatic resection for colorectal liver metastases

Oba

Hasegawa

Shindoh

et al. 2016

Surgery

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supporting

confidence: 61%

Section: Discussionmentioning

confidence: 94%

Survival benefit of repeat resection of successive recurrences after the initial hepatic resection for colorectal liver metastases

Oba

Hasegawa

Shindoh

et al. 2016

Surgery

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“…Similarly, there is no consensus on frequent resection in the case of hepatic metastasis. However, Kulik et al reported that recurrent colorectal liver metastasis surgery is feasible, with morbidity and mortality rates similar to those for resection of initial or single colorectal liver metastases (3).…”

Section: Discussionmentioning

confidence: 99%

Combined resection of re‐recurrent lateral lymph nodes and external iliac vein:Case Report and Literature

et al. 2018

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Herein, we describe the operative procedure for combined resection of re-recurrent lateral lymph nodes and the external iliac vein. There is no consensus on the clinical implications of resection of locally re-recurrent colorectal tumors, as the operative procedure is extremely difficult. We present the case of a 52-year-old woman who underwent abdominoperineal resection. About one year later, we excised a recurrent lymph node in the left lateral obturator area through an extraperitoneal approach. About 18 months later, lymph node re-recurrence in the left external iliac area was observed. Re-recurrent lymph nodes directly invade the left external iliac vein. We removed the re-recurrent lymph node with combined, radical segmental resection of the left external iliac vein, left obturator artery and vein, and left obturator nerve. J. Med. Invest. 65:136-138, February, 2018.

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“…In previous studies, the number of CRLM was thought to be a prognostic factor for repeat hepatectomy. However, this has not been well studied compared with primary hepatectomy [6,11] . Major hepatectomy is associated with high morbidity rate.…”

Section: Discussionmentioning

confidence: 99%

Repeat hepatic resection in patients with colorectal liver metastases

Lee¹,

Choi

Cho

et al. 2015

WJG

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AIM:To investigate the survival outcomes of secondary hepatectomy for recurrent colorectal liver metastases (CRLM). METHODS:From October 1994 to December 2009, patients with CRLM who underwent surgical treatment with curative intent were investigated. Patients were divided into two groups: patients who underwent primary hepatectomy (Group 1) and those who underwent secondary hepatectomy for recurrent CRLM (Group 2). RESULTS:Survival and prognostic factors were analyzed. A total of 461 patients were included: 406 patients in Group 1 and 55 patients in Group 2. After a median 39-mo (range, 3-195 mo) follow-up, there was a significant difference between Groups 1 and 2 in terms of disease-free survival (P = 0.029) although there was no significant difference in overall survival (P = 0.206). Secondary hepatectomy was less effective in patients with multiple recurrent CRLM than primary hepatectomy for initial CRLM (P = 0.008). Multiple CRLM and radiofrequency ablation therapy were poor prognostic factors of secondary hepatectomy in multivariate Cox regression analysis (P = 0.006, P = 0.004, respectively). CONCLUSION:Secondary hepatectomy for single recurrent CRLM is as effective as primary surgical treatment for single recurrent CRLM. However, secondary hepatectomy for multiple recurrent CRLM is less effective than that for single recurrent CRLM. Retrospective Study ORIGINAL ARTICLEHowever, secondary hepatectomy for multiple recurrent CRLM is less effective than that for single recurrent CRLM.

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Repeat liver resection for colorectal metastases

Abstract: Recurrent CLM surgery is feasible with similar morbidity and mortality rates to those of initial or single CLM resections.

Cited by 54 publications

References 24 publications

Survival benefit of repeat resection of successive recurrences after the initial hepatic resection for colorectal liver metastases

Survival benefit of repeat resection of successive recurrences after the initial hepatic resection for colorectal liver metastases

Combined resection of re‐recurrent lateral lymph nodes and external iliac vein:Case Report and Literature

Repeat hepatic resection in patients with colorectal liver metastases

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