Repeat Hepatectomy After Major Hepatectomy for Colorectal Liver Metastases

Takamoto, Takeshi; Hashimoto, Takeji; Miyata, Akinori; Shimada, Kaoru; Maruyama, Yoshikazu; Makuuchi, Masatoshi

doi:10.1007/s11605-019-04154-8

Cited by 23 publications

(22 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The safety and effectiveness of repeat hepatectomy in selected patients have been reported in several studies. [1][2][3][4][5][6] With proper selection, repeat hepatectomy is considered safe, with similar mortality and morbidity to the initial hepatectomy. In well-selected patients, median OS after second hepatectomy has been reported to range from 32 to 43 months, 2,6,8,17 and 5-year OS rates ranged from 30% to 48%.…”

Section: Discussionmentioning

confidence: 99%

“…16 Previous studies identified factors associated with worse OS to include CRLM larger than 5 cm at initial hepatectomy, age below 40 years at initial hepatectomy, more than 5 liver tumors at repeat hepatectomy, and major hepatectomy at time of repeat resection. 1,5 A concern about previous studies is their small sample size, limiting the power of their analyses. None of these previously identified prognostic factors at the time of initial hepatectomy was associated with OS in multivariable analysis in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Repeat resection of colorectal liver metastases (CRLM) is safe and feasible. [1][2][3][4][5][6] Nearly half of all patients undergo re-resection and/or ablation for intrahepatic recurrences after initial resection of CRLM. 2,7 Previous studies have demonstrated favorable overall survival (OS) for highly selected patients after repeat hepatectomy, with a 5-year OS of almost 50%.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Recurrence After Liver Resection of Colorectal Liver Metastases: Repeat Resection or Ablation Followed by Hepatic Arterial Infusion Pump Chemotherapy

et al. 2020

View full text Add to dashboard Cite

Background. The aim of this study was to investigate the effectiveness of adjuvant hepatic arterial infusion pump (HAIP) chemotherapy after complete resection or ablation of recurrent colorectal liver metastases (CRLM). Methods. A retrospective cohort study was conducted of patients from two centers who were treated with resection and/or ablation of recurrent CRLM only between 1992 and 2018. Overall survival (OS) and hepatic disease-free survival (hDFS) were estimated using the Kaplan-Meier method. The Cox regression method was used to calculate hazard ratios (HRs) with corresponding 95% confidence intervals (CI). Results. Of 374 eligible patients, 81 (22%) were treated with adjuvant HAIP chemotherapy. The median follow-up for survivors was 65 months (IQR 32-118 months). Patients receiving adjuvant HAIP were more likely to have multifocal disease and receive perioperative systemic chemotherapy at time of resection for recurrence. A

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Recurrence After Liver Resection of Colorectal Liver Metastases: Repeat Resection or Ablation Followed by Hepatic Arterial Infusion Pump Chemotherapy

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Large international multi-institutional retrospective series and several other groups on repeat partial hepatectomy with curative intent of new CRLM demonstrated 5-year OS following the second treatment reaching 51% [ 19 , 20 , 21 , 22 ]. As a result the current standard of care for new CRLM is repeat local treatment, either upfront or after induction chemotherapy [ 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Thermal Ablation Compared to Partial Hepatectomy for Recurrent Colorectal Liver Metastases: An Amsterdam Colorectal Liver Met Registry (AmCORE) Based Study

Dijkstra

Nieuwenhuizen

Puijk

et al. 2021

Cancers

View full text Add to dashboard Cite

The aim of this study was to assess safety, efficacy and survival outcomes of repeat thermal ablation as compared to repeat partial hepatectomy in patients with recurrent colorectal liver metastases (CRLM). This Amsterdam Colorectal Liver Met Registry (AmCORE) based study of two cohorts, repeat thermal ablation versus repeat partial hepatectomy, analyzed 136 patients (100 thermal ablation, 36 partial hepatectomy) and 224 tumors (170 thermal ablation, 54 partial hepatectomy) with recurrent CRLM from May 2002 to December 2020. The primary and secondary endpoints were overall survival (OS), distant progression-free survival (DPFS) and local tumor progression-free survival (LTPFS), estimated using the Kaplan–Meier method, and complications, analyzed using the chi-square test. Multivariable analyses based on Cox proportional hazards model were used to account for potential confounders. In addition, subgroup analyses according to patient, initial and repeat local treatment characteristics were performed. In the crude overall comparison, OS of patients treated with repeat partial hepatectomy was not statistically different from repeat thermal ablation (p = 0.927). Further quantification of OS, after accounting for potential confounders, demonstrated concordant results for repeat local treatment (hazard ratio (HR), 0.986; 95% confidence interval (CI), 0.517–1.881; p = 0.966). The 1-, 3- and 5-year OS were 98.9%, 62.6% and 42.3% respectively for the thermal ablation group and 93.8%, 74.5% and 49.3% for the repeat resection group. No differences in DPFS (p = 0.942), LTPFS (p = 0.397) and complication rate (p = 0.063) were found. Mean length of hospital stay was 2.1 days in the repeat thermal ablation group and 4.8 days in the repeat partial hepatectomy group (p = 0.009). Subgroup analyses identified no heterogeneous treatment effects according to patient, initial and repeat local treatment characteristics. Repeat partial hepatectomy was not statistically different from repeat thermal ablation with regard to OS, DPFS, LTPFS and complications, whereas length of hospital stay favored repeat thermal ablation. Thermal ablation should be considered a valid and potentially less invasive alternative for small-size (0–3 cm) CRLM in the treatment of recurrent new CRLM. While, the eagerly awaited results of the phase III prospective randomized controlled COLLISION trial (NCT03088150) should provide definitive answers regarding surgery versus thermal ablation for CRLM.

show abstract

“…The rate of repeat hepatectomy may vary according to the expertise and to the surgical policy of the Center. The reported rates of repeat hepatectomy range from 8% to 35% (14). A recent Eastern paper by Takamoto et al (14) reported a high rate of repeat hepatectomy (50% for all recurrences and 87% for liver only recurrences).…”

mentioning

confidence: 99%

Possibility of repeat surgery for recurrence following two-stage hepatectomy for colorectal liver metastases: impact on patient outcome

Ardito

2020

Hepatobiliary Surg Nutr

View full text Add to dashboard Cite

Repeat Hepatectomy After Major Hepatectomy for Colorectal Liver Metastases

Cited by 23 publications

References 31 publications

Recurrence After Liver Resection of Colorectal Liver Metastases: Repeat Resection or Ablation Followed by Hepatic Arterial Infusion Pump Chemotherapy

Recurrence After Liver Resection of Colorectal Liver Metastases: Repeat Resection or Ablation Followed by Hepatic Arterial Infusion Pump Chemotherapy

Thermal Ablation Compared to Partial Hepatectomy for Recurrent Colorectal Liver Metastases: An Amsterdam Colorectal Liver Met Registry (AmCORE) Based Study

Possibility of repeat surgery for recurrence following two-stage hepatectomy for colorectal liver metastases: impact on patient outcome

Contact Info

Product

Resources

About