REPDOSE: A database on repeated dose toxicity studies of commercial chemicals—A multifunctional tool

Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the Transatlantic Think Tank for Toxicology (t4)

“…According to the of nervous system involvement in adult studies e.g. repeated dose toxicity studies 3) Have a mode of action that has been closely linked to neurotoxic or developmental neurotoxicity effects evaluations of repeated-dose toxicity studies (Bitsch et al, 2006) suggest about 10% of chemicals cause neurotoxic effects, thus we assume that in half of the cases (5%) DNt studies will be considered and carried out in 2.5%, as suggested in the OeCD tG 426. this is disputed by some practitioners, but optimistically we will assume that this is possible in half of the cases, resulting in a 50% cost reduction and no additional animals. Furthermore, it is suggested that "evidence of endocrine disruption seen in a repeated dose toxicity study provides a trigger for the conduct of a more comprehensive study, for example a two-generation study."…”

A category approach to predicting the hemolytic effects of ethylene glycol alkyl ethers in repeated-dose toxicity

“…The data quality used in this study is reasonably high because all the data were derived from RDT DB and RepDose DB, where studies were carefully selected by data quality (Hayashi and Sakuratani, 2011;Bitsch et al, 2006). The toxicity endpoint of the category is hemolytic effects, which is one of the endpoints used for regulatory decisions.…”

“…The database will be published in 2012 and is provisionally termed the RDT DB in this study. For evaluating a category, seven chemicals were selected from RepDose DB, a database on RDT studies of commercial chemicals developed by Fraunhofer Institute of Toxicology and Experimental Medicine, Germany, (Bitsch et al, 2006). Chemicals and their abbreviations, and the data source of the RDT test data are depicted in Table 1.…”

The ChemScreen project to design a pragmatic alternative approach to predict reproductive toxicity of chemicals

“…This can be complemented with other in silico, or in vitro test information on these compounds. We expanded databases that contain information relevant to reproductive toxicity in the RepDose (repeated dose) [15] and FeDTex (fertility and developmental toxicity) databases [16]. First, reproductive toxicity studies were identified from peer reviewed publications.…”