Repatterning in amphibian limb regeneration: A model for study of genetic and epigenetic control of organ regeneration

Yakushiji, Nayuta; Yokoyama, Hitoshi; Tamura, Koji

doi:10.1016/j.semcdb.2008.12.007

Cited by 56 publications

(48 citation statements)

References 109 publications

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“…Evolutionary novelties often arise through combinatorial processes (Sanetra et al, 2005). Therefore, the co-option of conserved genes and signaling pathways, together with the trans-acting regulatory factors and their epigenetic regulation (Yakushiji et al, 2007(Yakushiji et al, , 2009, could explain why different species have a regenerative capability without necessarily invoking a common origin or only multiple losses.…”

Section: Resultsmentioning

confidence: 99%

“…Wnt, BMP and Nodal represent the signaling pathways defining the body axes during embryonic development, at least in bilaterians. These pathways were possibly present in the most recent common ancestor of all metazoans (reviewed in Holstein et al, 2011) and their involvement in whole body or body structure re-patterning has been reported in cnidarians, acoel, platyhelminthes, and deuterostomes (Holstein et al, 2003;Yakushiji et al, 2009;Adell et al, 2010;Reddien, 2011;Srivastava et al, 2014;Watanabe et al, 2014).…”

Section: Morphogenetic Events In Regenerationmentioning

confidence: 99%

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Reconsidering regeneration in metazoans: an evo-devo approach

Tiozzo

Copley

2015

Front. Ecol. Evol.

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Regeneration of body structures is an ability widely but unevenly distributed amongst the animal kingdom. Understanding regenerative biology in metazoans means understanding the multiplicity of the cellular and molecular mechanisms that lead to the differentiation, morphogenesis and ultimately the development of a particular regenerating unit. In this manuscript we critically assess the evolutionary considerations suggesting that regeneration is an ancestral trait rather than a mechanism independently evolved in different taxa. As a general method to test evolutionary hypothesis on regeneration, we propose mechanistically dissecting the regenerative processes according to its conserved chronological steps: wound healing, mobilization of cell precursors and morphogenesis. We then suggest interpreting regenerative biology from an evo-devo perspective, proposing a possible theoretical framework and experimental approaches without necessarily invoking a common origin or only multiple losses of regenerative capabilities.

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Section: Resultsmentioning

confidence: 99%

Section: Morphogenetic Events In Regenerationmentioning

confidence: 99%

Reconsidering regeneration in metazoans: an evo-devo approach

Tiozzo

Copley

2015

Front. Ecol. Evol.

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“…Treatment of amputated froglet limbs with an agonist of Hedgehog signaling, the synthetic small molecule Hh‐Ag, induced activation of target genes of Shh and the formation of multiple cartilaginous structures instead of a single spike (Yakushiji, Suzuki, Satoh, Ide, & Tamura, 2009). These results suggest that Shh expression is necessary for froglet limb regeneration (Yakushiji, Yokoyama, & Tamura, 2009). …”

Section: Blastema Growthmentioning

confidence: 93%

Mechanisms of urodele limb regeneration

Stocum

2017

Regeneration

109

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This review explores the historical and current state of our knowledge about urodele limb regeneration. Topics discussed are (1) blastema formation by the proteolytic histolysis of limb tissues to release resident stem cells and mononucleate cells that undergo dedifferentiation, cell cycle entry and accumulation under the apical epidermal cap. (2) The origin, phenotypic memory, and positional memory of blastema cells. (3) The role played by macrophages in the early events of regeneration. (4) The role of neural and AEC factors and interaction between blastema cells in mitosis and distalization. (5) Models of pattern formation based on the results of axial reversal experiments, experiments on the regeneration of half and double half limbs, and experiments using retinoic acid to alter positional identity of blastema cells. (6) Possible mechanisms of distalization during normal and intercalary regeneration. (7) Is pattern formation is a self‐organizing property of the blastema or dictated by chemical signals from adjacent tissues? (8) What is the future for regenerating a human limb?

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“…As the blastema grows, its more proximal cells are left out of range of these factors and these cells cease expression of Hoxa 13, creating a boundary between prospective autopodium and zeugopodium/stylopodium. It is likely that a third boundary, separating prospective stylopodium and zeugopodium, is also established and that transcription factors such as Hoxa11 may specify this boundary (see Yakushiji et al, 2009;Tamura et al, 2010;Ohgo et al, 2010). Resorption of proximal blastema cells or failure of the accumulation blastema to grow would prevent separation of autopodial and more proximal domains and lead to formation of hand parts only.…”

Section: The Blastema Is Self-organizingmentioning

confidence: 99%

Looking proximally and distally: 100 years of limb regeneration and beyond

Stocum

Cameron

2011

Developmental Dynamics

106

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The experimental study of amphibian limb regeneration spans most of the 20 th century and the first decade of the 21 st century. We first review the major questions investigated over this time span: (1) the origin of regeneration blastema cells, the mechanism of tissue breakdown that liberates cells from their tissue organization to participate in blastema formation, (3) the mechanism of dedifferentiation of these cells, (4) how the blastema grows, (5) how the blastema is patterned to restore the missing limb structures, and (6) why adult anurans, birds and mammals do not have the regenerative powers of urodele salamanders. We then look forward in a perspective to discuss the many unanswered questions raised by investigations of the past century, what new approaches can be taken to answer them, and what the prospects are for translation of basic research on limb regeneration into clinical means to regenerate human appendages. Developmental Dynamics 240:943-968,

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Repatterning in amphibian limb regeneration: A model for study of genetic and epigenetic control of organ regeneration

Cited by 56 publications

References 109 publications

Reconsidering regeneration in metazoans: an evo-devo approach

Reconsidering regeneration in metazoans: an evo-devo approach

Mechanisms of urodele limb regeneration

Looking proximally and distally: 100 years of limb regeneration and beyond

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