Repair of transperineal recto‐urethral fistula using a fibrin sealant haemostatic patch

Giuliani, Giuseppe; Guerra, Francesco; Coletta, Diego; Torre, M. La; Franco, Giorgio; Leonardo, C.; Infantino, A.; Torre, Filippo La

doi:10.1111/codi.13518

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…A number of biomaterials have been evaluated as potential treatments of noncompressible hemorrhage. Scientists have long sought to harness the clotting power of fibrin to create hemostatic dressings or bandages . Fibrin‐based hemostatic sealants were first investigated in the 1940s and proved to be quite useful .…”

Section: Introductionmentioning

confidence: 99%

Hemostasis mechanism and applications of N-alkylated chitosan sponge

Huang

Feng

Zhang

et al. 2017

Polym. Adv. Technol.

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Chitosan (CHI) is a versatile biological material that is well known for its hemostatic properties. This preliminary study evaluated several self-assembling hydrophobically modified chitosan (HM-CHI) sponges to determine their efficacy on hemostasis. Fourier transform infrared (FT-IR) spectroscopy was used to determine the successful graft of dodecyl groups onto the nitrogen atoms of CHI molecules. A platelet aggregation assay revealed that HM-CHI accelerated the platelet aggregation rate. Fluorescence spectroscopy showed that the HM-CHI changed the structure of fibrinogen in blood. Activated partial thromboplastin time, prothrombin time, fibrinogen time, and thromboelastographic assays were used to explore the effect of HM-CHI on the autologous blood coagulation pathway. Finally, a hemostatic sponge was made with HM-CHI and freeze-dried zeolite composite film and was applied to the rat femoral artery hemostasis model. A hemostasis time of 86 AE 5 sec was achieved, which was significantly better than the one composed with pure CHI. The experimental results of the HM-CHI hemostatic materials are inspiring and will encourage the research and development of such materials. HM-CHI may be a strong candidate as a safe and effective hemostatic material.

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Section: Introductionmentioning

confidence: 99%

Hemostasis mechanism and applications of N-alkylated chitosan sponge

Huang

Feng

Zhang

et al. 2017

Polym. Adv. Technol.

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“…In one series, Giuliani et al demonstrated successful closure of rectourethral fistulas in four of five patients when Tachosil® was used. 15 Giusti et al successfully utilized Tachosil® as an interposition tissue in a series of 16 laparoscopic extravesical vesicovaginal fistula repairs. 16 However, the relative contribution of Tachosil to the success of the repair is unknown, and therefore its utility in UCF repairs remains to be demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and management of urethro-cavernosal fistulas

Han

Ghodoussipour

Kreydin

et al. 2020

Journal of Clinical Urology

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Objective: To present a case series of urethro-cavernosal fistulas evaluating their diagnostic work-up and management. Methods: A literature search was performed using key words including “urethro-cavernosal fistula,” “urethral fistula,” and “cavernosal fistula.” Results: In total 10 case reports were identified and reviewed for information regarding clinical diagnosis, management, and long-term outcomes including success rates and complications. Conclusion: Urethro-cavernosal fistula is a rare urological condition. With few cases reported to date, there is considerable variation in diagnostic work-up and management. Both conservative and surgical approaches can be utilized in the management of urethro-cavernosal fistulas with good long-term outcomes. Level of evidence: Not applicable for this multicentre audit.

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“…Addition of bioactive materials is a promising pathway to improve the performance of PEO-based nanofibers, and the use of clotting power of fibrin to create hemostatic dressings can be quite useful. , In this sense, the loading of thrombin inside PEO nanofibers increases their bioactive potential, resulting in a dressing with faster blood clotting capacity. Polymer–protein conjugates are able to form complex molecules with particular interest in the fields of biomedicine .…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibrous Architectures of Thrombin-Loaded Poly(ethylene oxide) for Faster in Vivo Wound Clotting

Mendes

Ferreira

Sielski

et al. 2021

ACS Appl. Bio Mater.

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Wound healing materials to prevent blood loss are crucial during emergency medical treatment because uncontrolled bleeding can lead to patient death. Herein, bioabsorbable fibrous architectures of thrombin-loaded poly(ethylene oxide)PEO/thrombinare conceptualized and accomplished via electrospinning for faster wound clotting. Membranes with average fiber diameters ranging from 188 to 264 nm are achieved, where the active thrombin is entrapped within the nanofibers. The results of in vitro and in vivo wound healing activity tests revealed that when the nanofibers with thrombin-loaded capacity are in contact with the wound, the presence of water in the skin or blood catalyzes the degradation of the membranes, thus releasing thrombin. Thrombin then accelerates the wound clotting process. In contrast to other hemostatic materials, PEO/thrombin nanofibers do not require mechanical removal after application, and the viscoelastic nature of such biomaterials enables their conformation to a variety of wound topographies. Remarkably, PEO/thrombin membranes are promising functional materials and their use is a powerful strategy for hemostatic treatment, ranging from simple first aid and sealing to a wound to small surgical procedures.

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Repair of transperineal recto‐urethral fistula using a fibrin sealant haemostatic patch

Abstract: Direct transperineal repair of RUF reinforced with a fibrin haemostatic patch of TachoSil is safe and effective.

Cited by 5 publications

References 8 publications

Hemostasis mechanism and applications of N-alkylated chitosan sponge

Hemostasis mechanism and applications of N-alkylated chitosan sponge

Diagnosis and management of urethro-cavernosal fistulas

Electrospun Nanofibrous Architectures of Thrombin-Loaded Poly(ethylene oxide) for Faster in Vivo Wound Clotting

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