Repair of sheep articular cartilage defects with a rabbit costal perichondrial graft

Immediate Postextraction Implant Placement in Sheep's Mandibles: A Pilot Study

“…4,20,21 Sheep are becoming more popular as animal model in bone research in recent years. Their use has been reported in studies on critical-sized defect models in bone substitute research, 22,23 joint research, 24 periodontitis studies, 25 and facial bone/maxillary sinus augmentation techniques. 26 Their popularity is most likely related to their nature as higher level vertebrate and their nonpet status.…”

Endochondral Bone Formation as Blueprint for Regenerative Medicine

“…Perichondrial Arthroplasty used for human cartilage repair was first described by Skoog et al (Skoog and Johansson 1976). This technique has been reported to give an initial cartilage repair (Homminga, Bulstra et al 1990;Homminga, Bulstra et al 1991). On the long term poor results related to overgrowth of the graft and calcification are reported by Bouwmeester et al (Bouwmeester, Beckers et al 1997).…”

“…Interestingly, cells used for bone regeneration are almost always progenitor cells, whereas for cartilage regeneration also differentiated cells are used, next to progenitor cells. Some authors prefer the use of chondrocytes for transplantation while others prefer the use of undifferentiated multipotent cells (Skoog and Johansson 1976;O'Driscoll, Keeley et al 1986;Homminga, Bulstra et al 1991;Brittberg, Lindahl et al 1994;Lindahl, Brittberg et al 2003;Nathan, Das De et al 2003;Emans, Surtel et al 2005;Park, Sugimoto et al 2005).Mature chondrocytes can be released from their cartilaginous matrix, selected and expanded in vitro.…”

“…Both chondrocytes and progenitor cells originating from different cell sources have been studied in combination with various biomaterials (Bentley and Greer 1971;Haynesworth, Baber et al 1992;Freed, Marquis et al 1993;Freed, Vunjak-Novakovic et al 1993;Iwasaki, Nakata et al 1993;Brittberg, Lindahl et al 1994;Bruder, Fink et al 1994;Freed, Grande et al 1994;Gallay, Miura et al 1994;Wakitani, Goto et al 1994;Iwasaki, Nakahara et al 1995). Bone marrow, adipose tissue, synovium, dental pulp, perichondrium and periosteum can serve as a source for multipotent cells (Skoog and Johansson 1976;Homminga, Bulstra et al 1991;Bouwmeester, Beckers et al 1997;Chu, Dounchis et al 1997;O'Driscoll, Saris et al 2001;Nathan, Das De et al 2003;Emans, Surtel et al 2005;Park, Sugimoto et al 2005). Numerous publications described subpopulations of progenitor cells in these donor tissues that might be more optimal cell sources than e.g.…”

Cartilage Tissue Engineering; Lessons Learned From Periosteum

“…Perichondrial arthroplasty used for human cartilage repair was first described by Skoog et al [32]. This technique has been reported to give an initial cartilage repair in the defect [33,34]. On the long term poor results related to overgrowth of the graft and ossification are reported by Bouwmeester et al [26].…”