Repair of osteonecrosis of the femoral head

Wang, Ping; Li, Gang; Wen, Qin; Shi, Bin; Liu, Fan-jie; Wang, Leilei; Zhao, Bonian; Sun, Tiefeng; Li, Gang; Wang, Dandan

doi:10.1007/s00132-018-03678-2

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…They implanted the scaffold into the femoral head of the mouse model with osteonecrosis of the femoral head (ONFH) to repair osteonecrosis (Figure 3B) and found that the CCC deproteinized bone scaffold significantly reduced femoral head necrosis in rats (Figure 3C). In vitro experiments also showed that osteoblasts aggregated and adhered in the pore structure of the CCC deproteinized bone scaffold, and the CCCdeproteinized bone scaffold enhances the proliferation of osteoblasts (Wang et al, 2019b).…”

Section: Cervi Cornus Collamentioning

confidence: 96%

“…CCC has been used to prevent and treat acute and chronic arthritis, osteoporosis, fractures, hypercholesterolemia, and other diseases (Kim et al, 2013;Li et al, 2014). Wang et al (2019b) processed the proximal pig femur to obtain a deproteinized bone meal. After mixing the deproteinized bone meal with CCC and synthetic organic materials, CCC-deproteinized bone scaffolds were made by 3D printing technology.…”

Section: Cervi Cornus Collamentioning

confidence: 99%

mentioning

confidence: 99%

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Polymer Scaffolds-Enhanced Bone Regeneration in Osteonecrosis Therapy

Dong

Zhu

Zhang

et al. 2021

Front. Bioeng. Biotechnol.

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Osteonecrosis without effective early treatment eventually leads to the collapse of the articular surface and causes arthritis. For the early stages of osteonecrosis, core decompression combined with bone grafting, is a procedure worthy of attention and clinical trial. And the study of bone graft substitutes has become a hot topic in the area of osteonecrosis research. In recent years, polymers have received more attention than other materials due to their excellent performance. However, because of the harsh microenvironment in osteonecrosis, pure polymers may not meet the stringent requirements of osteonecrosis research. The combined application of polymers and various other substances makes up for the shortcomings of polymers, and to meet a broad range of requirements for application in osteonecrosis therapy. This review focuses on various applying polymers in osteonecrosis therapy, then discusses the development of biofunctionalized composite polymers based on the polymers combined with different bioactive substances. At the end, we discuss their prospects for translation to clinical practice.

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Section: Cervi Cornus Collamentioning

confidence: 96%

Section: Cervi Cornus Collamentioning

confidence: 99%

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Polymer Scaffolds-Enhanced Bone Regeneration in Osteonecrosis Therapy

Dong

Zhu

Zhang

et al. 2021

Front. Bioeng. Biotechnol.

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“…Earlier studies have indicated that the cellular outcomes, including cell survival, differentiation and intracellular component synthesis, during the process of cartilage remodelling and repair are influenced by the 3‐dimensional structure and pore size of the material 32 . Accordingly, a scaffold with a pore size ranging from100 to 300 μm demonstrates optimal suitability for promoting cell survival, migration and homing 33 . In the present study, the viability and proliferation ability of the PBMSCs that were seeded on the scaffold with a network structure were found to be higher compared to the control group.…”

Section: Disscussionmentioning

confidence: 99%

ICA/SDF‐1α/PBMSCs loaded onto alginate and gelatin cross‐linked scaffolds promote damaged cartilage repair

Wang,

Zhu,

Yin

et al. 2024

J Cellular Molecular Medi

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A three‐dimensional alginate‐coated scaffold (GAIS) was constructed in the present study to showcase the multidifferentiation potential of peripheral blood mesenchymal stem cells (PBMSCs) and to investigate the role and mechanism by which Icariin (ICA)/stromal cell‐derived factor (SDF‐1α)/PBMSCs promote damaged articular repair. In addition, the ability of ICA, in combination with SDF‐1α, to promote the migration and proliferation of stem cells was validated through the utilization of CCK‐8 and migration experiments. The combination of ICA and SDF‐1α inhibited the differentiation of PBMSCs into cartilage, as demonstrated by in vivo experiments and histological staining. Both PCR and western blot experiments showed that GAIS could upregulate the expression of particular genes in chondrocytes. In comparison to scaffolds devoid of alginate (G0), PBMSCs seeded into GAIS scaffolds exhibited a greater rate of proliferation, and the conditioned medium derived from scaffolds containing SDF‐1α enhanced the capacity for cell migration. Moreover, after a 12‐week treatment period, GAIS, when successfully transplanted into osteochondral defects of mice, was found to promote cartilage regeneration and repair. The findings, therefore, demonstrate that GAIS enhanced the in vitro capabilities of PBMSCs, including proliferation, migration, homing and chondrogenic differentiation. In addition, ICA and SDF‐1α effectively collaborated to support cartilage formation in vivo. Thus, the ICA/SDF‐1α/PBMSC‐loaded biodegradable alginate‐gelatin scaffolds showcase considerable potential for use in cartilage repair.

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“…Their femoral heads had less destruction of chondrocytes along with limited necrosis. In addition, the rats showed no signs of an immune response to the scaffold [ 81 ]. Zhu et al used a novel PLLA/PLGA/PCL scaffold seeded with BMP and combined with low intensity pulsed ultrasound (LIPUS) to observe its effect in repairing ONFH in the rat model.…”

Section: Desired Characteristics Of 3d Scaffoldsmentioning

confidence: 99%

Tissue Engineering Strategies for Treating Avascular Necrosis of the Femoral Head

et al. 2021

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Avascular necrosis (AVN) of the femoral head commonly leads to symptomatic osteoarthritis of the hip. In older patients, hip replacement is a viable option that restores the hip biomechanics and improves pain but in pediatric, adolescent, and young adult patients hip replacements impose significant activity limitations and the need for multiple revision surgeries with increasing risk of complication. Early detection of AVN requires a high level of suspicion as diagnostic techniques such as X-rays are not sensitive in the early stages of the disease. There are multiple etiologies that can lead to this disease. In the pediatric and adolescent population, trauma is a commonly recognized cause of AVN. The understanding of the pathophysiology of the disease is limited, adding to the challenge of devising a clinically effective treatment strategy. Surgical techniques to prevent progression of the disease and avoid total hip replacement include core decompression, vascular grafts, and use of bone-marrow derived stem cells with or without adjuncts, such as bisphosphonates and bone morphogenetic protein (BMP), all of which are partially effective only in the very early stages of the disease. Further, these strategies often only improve pain and range of motion in the short-term in some patients and do not predictably prevent progression of the disease. Tissue engineering strategies with the combined use of biomaterials, stem cells and growth factors offer a potential strategy to avoid metallic implants and surgery. Structural, bioactive biomaterial platforms could help in stabilizing the femoral head while inducing osteogenic differentiation to regenerate bone and provide angiogenic cues to concomitantly recover vasculature in the femoral head. Moreover, injectable systems that can be delivered using a minimal invasive procedure and provide mechanical support the collapsing femoral head could potentially alleviate the need for surgical interventions in the future. The present review describes the limitations of existing surgical methods and the recent advances in tissue engineering that are leading in the direction of a clinically effective, translational solution for AVN in future.

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Repair of osteonecrosis of the femoral head

Cited by 6 publications

References 24 publications

Polymer Scaffolds-Enhanced Bone Regeneration in Osteonecrosis Therapy

Polymer Scaffolds-Enhanced Bone Regeneration in Osteonecrosis Therapy

ICA/SDF‐1α/PBMSCs loaded onto alginate and gelatin cross‐linked scaffolds promote damaged cartilage repair

Tissue Engineering Strategies for Treating Avascular Necrosis of the Femoral Head

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