Repair of large airway defects with bioprosthetic materials

Petrella, Francesco; Spaggiari, Lorenzo

doi:10.21037/jtd.2017.09.104

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…Combination of autologous mesenchymal stromal cells and tissue-engineered scaffolds is an interesting and rapidly evolving approach in the regenerative medicine arena, potentially suitable also to support the healing of large-size fistulas and partial or long-segment defects of the esophagus [ 110 ]. The ideal scaffold should be biocompatible and biodegradable, with a degradation rate similar to the tissue regeneration time.…”

Section: Future Directionsmentioning

confidence: 99%

Regenerative medicine approaches for the management of respiratory tract fistulas

et al. 2020

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Respiratory tract fistulas (or fistulae) are abnormal communications between the respiratory system and the digestive tract or the adjacent organs. The origin can be congenital or, more frequently, iatrogenic and the clinical presentation is heterogeneous. Respiratory tract fistulas can lead to severely reduced health-related quality of life and short survival. Therapy mainly relies on endoscopic surgical interventions but patients often require prolonged hospitalization and may develop complications. Therefore, more conservative regenerative medicine approaches, mainly based on lipotransfer, have also been investigated. Adipose tissue can be delivered either as unprocessed tissue, or after enzymatic treatment to derive the cellular stromal vascular fraction. In the current narrative review, we provide an overview of the main tissue/cell-based clinical studies for the management of various types of respiratory tract fistulas or injuries. Clinical experience is limited, as most of the studies were performed on a small number of patients. Albeit a conclusive proof of efficacy cannot be drawn, the reviewed studies suggest that grafting of adipose tissue-derived material may represent a minimally invasive and conservative treatment option, alternative to more aggressive surgical procedures. Knowledge on safety and tolerability acquired in prior studies can lead to the design of future, larger trials that may exploit innovative procedures for tissue processing to further improve the clinical outcome.

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Section: Future Directionsmentioning

confidence: 99%

Regenerative medicine approaches for the management of respiratory tract fistulas

et al. 2020

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“…Combining autologous Mesenchymal stromal Cells as well as tissue engineering scaffold is a significant as well as fast evolving strategy in the regenerative medicine scenario, that is probably appropriate for the healing of large sized fistulas as well as partially or long segment defects of the esophagus [105]. The best scaffold needs to be biocompatible along with biodegradable, with a breakdown rate equivalent to the tissue regeneration time.…”

Section: Future Workmentioning

confidence: 99%

Utilizing Adipose Tissue-Derived Stem Cell Strategies for Obtaining Regeneration of Respiratory Tract Fistulas-A Systematic Review

Kaur¹,

Allahbadia²,

Singh³

2020

JRMBR

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“…It is based on the source and type of cells, type of scaffold, and composition of the extracellular matrix. In the complex field of airway and lung regeneration, several cases of tracheal bioengineering have been reported (11)(12)(13)(14), but the attractive concept of bioengineered tracheal replacements has not yielded a definitive and reliable solution (15).…”

Section: Lung Mimicking Devicesmentioning

confidence: 99%

Artificial lung

Petrella¹,

Spaggiari²

2018

J. Thorac. Dis.

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Lung transplantation remains the deﬁnitive curative treatment for end-stage lung disease. However, future applications of tissue bioengineering could overcome the donor organ shortage and the need for immunosuppression. The final goal of lung tissue engineering is to recreate the whole spectrum of specialized lung tissues and thereby provide physiologic functions through bioengineered conducting airways, vasculature and gas exchange tissue. This review focuses on ongoing research in artificial lung development, open questions, achievements to date and how tissue engineering and stem cell technology may further contribute to the clinical application of bioartificial lungs. Although experimental transplantation of bioartificial lung developed by perfusing decellularized or synthetic scaffolds has been shown to provide gas exchange over a prolonged period, it should be clearly acknowledged that the development of a transplantable bioartificial lung is far from reality.

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Repair of large airway defects with bioprosthetic materials

Cited by 5 publications

References 25 publications

Regenerative medicine approaches for the management of respiratory tract fistulas

Regenerative medicine approaches for the management of respiratory tract fistulas

Utilizing Adipose Tissue-Derived Stem Cell Strategies for Obtaining Regeneration of Respiratory Tract Fistulas-A Systematic Review

Artificial lung

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