Repair of human skull defects using osteoinductive bone alloimplants

Kübler, Norbert R.; Michel, Chantal; Zöller, J; Bill, Josip; Mühling, Joachim; Reuther, J.

doi:10.1016/s1010-5182(05)80128-3

Cited by 51 publications

(23 citation statements)

References 38 publications

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“…The transfer of bone autograft remains the preferred reconstructive method but is inadequate for large defects (9,10). There has been recent interest in the development of new grafting materials using allogeneic, xenogeneic and synthetic bioimplants for reconstructive bony procedures.…”

Section: Introductionmentioning

confidence: 99%

Influence of Autologus Adipose Derived Stem Cells and PRP on Regeneration of Dehiscence-Type Defects in Alveolar Bone: A Comparative Histochemical and Histomorphometric Study in Dogs

Aly

Menoufy²,

Hassan³

et al. 2011

Int J Stem Cells

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Background and Objectives: Autogenous bone grafts is considered to be the best choice for reconstructive surgery. Adipose Derived Stromal Cells (ASCs) represents a promising tool for new clinical concepts in supporting cellular therapy. The goal of our study was to investigate bone regeneration following application of autologous ASCs with or without Platelet-Rich Plasma (PRP) at dehiscence-type defects in alveolar bone in dogs. Methods and Results: Standardized buccal dehiscence defects (4×3×3 mm) were surgically created in eighteen dogs, the defects were grafted with either ASCs -PRP, ASCs alone, or without grafting material. Three months later; a bone core was harvested from grafted and non grafted sites for histological, histochemical and histomorphometric assessment. There was no evidence of inflammation or adverse tissue reaction with either treatment. Defects grafted with ASCs-PRP showed a significantly higher result (p≤0.05), with a mean area % of spongy bone and compact bone of (64.96±5.37 and 837.62±24.95), compared to ASCs alone (47.65±1.43 and 661.92±12.65) and without grafting (33.55±1.74 and 290.85±7.27) respectively. The area % of lamellated bone increased significantly reaching its highest level in group A followed by group B. Also a significant increase in area % of neutral mucopolysaccharides and calcified reactivity of Masson's Trichrome stain in groups A and B compared to group C was obtained. Conclusions: Our results suggest that, the addition of PRP to ASCs enhances bone formation after 3 months and may be clinically effective in accelerating postsurgical healing in both periodontal and maxillofacial surgical applications.

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Section: Introductionmentioning

confidence: 99%

Influence of Autologus Adipose Derived Stem Cells and PRP on Regeneration of Dehiscence-Type Defects in Alveolar Bone: A Comparative Histochemical and Histomorphometric Study in Dogs

Aly

Menoufy²,

Hassan³

et al. 2011

Int J Stem Cells

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“…These scaffolds derived from cortical and cancellous bone have been used extensively for clinical repair of bone injuries and abnormalities, including nonunion fractures, bone cysts, and cranio-maxillofacial reconstructions [1][2][3][4]. Both allografts and xenografts have been used in these clinical applications [1,[4][5][6][7][8]; however, the latter offers potential advantages in clinical therapies due to the unlimited supply of this bovine source of bone matrix, which is often restricted by donor availability when isolated from human sources [9].…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of differentially demineralized cancellous bone scaffolds combined with human bone marrow stromal cells for tissue engineering

et al. 2005

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“…Banked homologous fresh frozen cadaveric bone is nowadays routinely used in many surgeries [7, 13-16]. The risk of transmitting bacterial or viral infections undoubtedly exists, but it is markedly limited by the modern guidelines for bone procurement and processing.…”

Section: Discussionmentioning

confidence: 99%

“…However, homologous bone for pediatric cranioplasty did not gain wide acceptance owing to the relative rarity of large defects in very young children [5, 13, 15, 16]. In 2010, Brevi et al [13] reported a 33-month-old patient with Ewing’s sarcoma whose residual large frontal defect was repaired using autologous parietal bone, while the donor site was reconstructed using cadaveric bone.…”

Section: Discussionmentioning

confidence: 99%

Transplant of Adult Bone for Reconstruction of a Large Post-Traumatic Cranial Defect in a Very Young Baby

2019

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Large cranial defects in very young patients are challenging. The ideal material for cranioplasty in this age group has not yet been identified. Cryopreserved autologous bone presents very high rates of failures, acrylic resins pose a number of compatibility problems, bioceramics may be contraindicated, and autografts may be not adequate for repair of large defects. We present an 18-month-old baby with a large post-traumatic cranial defect which was repaired by assembling a new bone flap on a sterile stereolithographic 3-D model. This customized newly assembled flap consisted of a scaffold of autologous bone (from vault duplication) sustaining 2 large grafts of homologous cadaveric bone. It was adequately modeled and contoured on the 3-D model using metallic plates and screws. Immediately after implantation on the skull, the metallic devices were progressively replaced by reabsorbable material, thus maintaining the previously obtained flap profile. In this paper we detail this original technique which was developed to manage this specific patient.

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Repair of human skull defects using osteoinductive bone alloimplants

Cited by 51 publications

References 38 publications

Influence of Autologus Adipose Derived Stem Cells and PRP on Regeneration of Dehiscence-Type Defects in Alveolar Bone: A Comparative Histochemical and Histomorphometric Study in Dogs

Influence of Autologus Adipose Derived Stem Cells and PRP on Regeneration of Dehiscence-Type Defects in Alveolar Bone: A Comparative Histochemical and Histomorphometric Study in Dogs

In vitro and in vivo evaluation of differentially demineralized cancellous bone scaffolds combined with human bone marrow stromal cells for tissue engineering

Transplant of Adult Bone for Reconstruction of a Large Post-Traumatic Cranial Defect in a Very Young Baby

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