Repair of fistulas-in-ano using autologous fibrin tissue adhesive

Cintron, José; Park, John J.; Orsay, Charles P.; Pearl, Russell K.; Nelson, Richard L.; Abcarian, Herand

doi:10.1007/bf02234135

Cited by 102 publications

(66 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They reported an overall closure rate of 74% (17/ 23); however, 5 patients (22%) required 2 or 3 attempts at sealant closure. Results of our original study, 6 which used ethanol-based autologous fibrin tissue adhesive (AFTA-E), and our present study are similar to those of previous reported studies. Our surgical protocol differs, however, from other studies in that we do not treat our patients preoperatively with bowel preparations or antibiotics, and our patients are not hospitalized and are sent home postoperatively on a general diet.…”

Section: Commentsupporting

confidence: 83%

“…In one study, 26 patients with fistulae in ano were treated using autologous fibrin tissue adhesive that used a combination of ethanol and freezing to precipitate fibrinogen (AFTA-E). 6 Twentyone (81%) of the 26 patients had success- ful closure of their fistula after a 4-month follow-up. Two of the 5 failures were reinjected a second time and 1 closed, giving an overall successful closure rate of 85% (22 of 26 patients).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Repair of Chronic Anorectal Fistulae Using Commercial Fibrin Sealant

Park¹,

Cintron²,

Orsay

et al. 2000

Arch Surg

Self Cite

View full text Add to dashboard Cite

Section: Commentsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Repair of Chronic Anorectal Fistulae Using Commercial Fibrin Sealant

Park¹,

Cintron²,

Orsay

et al. 2000

Arch Surg

Self Cite

View full text Add to dashboard Cite

“…v. 46 -no. 4 Com relação aos 27 pacientes nos quais não houve cicatrização, em 9 pacientes (33,3%) a falha do tratamento foi diagnosticado nos primeiros 30 dias após a cirurgia, em 13 (48,8%) entre 1 e 3 meses, em 3 (11,1%) entre 3 e 6 meses e em 2 pacientes (7,4%) entre 6 e 9 meses após a cirurgia. Não foram observadas complicações relacionadas ao tratamento.…”

Section: Resultsunclassified

“…In the largest published series to date, CINTRON et al (4) reported a healing rate for cryptoglandular fistulas of 63%, compared with 35% for fistulas of other etiologies, with a mean follow-up of 1 year. Although no study has been able to demonstrate a statistically significant difference in healing rates according to fistula etiology (20) , it is generally agreed that anal fistulas associated with Crohn's diseases or HIV are usually more difficult to heal.…”

Section: Discussionmentioning

confidence: 99%

Fibrin glue in the management of complex anal fistula

Damin

Rosito

Contu

et al. 2009

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Context -Management of complex anal fistulas is associated with the risk of sphincter injury and fecal incontinence.In recent years, fibrin glue has emerged as an alternative sphincter-preserving treatment for anal fistulas. To date, however, there is no consensus about the efficacy of the method. Objective -To specifically evaluate the fibrin glue injection in the management of complex cryptoglandular anal fistulas. Methods -We studied a series of patients with complex anal fistulas treated with fibrin glue between January 2005 and January 2007. Only patients with fistulas of cryptoglandular origin were analyzed. Patients with fistulas related to Crohn's disease, HIV or previous surgery were excluded from the study. Under spinal anesthesia, the fistulas were curetted and injected with fibrin glue. After treatment, patients were followed-up for 12 months. Results -Thirty-two patients were enrolled in the study. Two patients were lost to follow-up and were excluded. Out of the remaining 30 patients, only three healed successfully (10%). Among the 27 patients who failed to heal, 9 (33.3%) were diagnosed within the first postoperative month. In 13 patients (48.1%) the failure of treatment occurred in the period between 1 and 3 months, in 3 patients (11.1%) between 3 and 6 months, and in 2 patients (7.4%) between 6 and 9 months after surgery. No treatment-related complications were observed. Conclusions -In this series, fibrin glue treatment for complex cryptoglandular anal fistulas achieved a very low healing rate. Our results do not support the use of fibrin glue as a first-line treatment for patients with this type of fistula. HEADINGS -Rectal fistula. Fibrin tissue adhesive. Tissue adhesives.

show abstract

“…These techniques have less risk of anal incontinence, despite some recurrences. Several studies on fibrin glue treatment of anal fistula have been published since 1999, but, the healing rate after debridement and fibrin glue injection is 14%-60% [22][23][24][25][26] . Use of anal fistula plug for complex fistula-in-ano repair [27,28] has a reported success rate of 83%.…”

Section: Discussionmentioning

confidence: 99%

A anorectal fistula treatment with acellular extracellular matrix: A new technique

Song¹,

Wang²,

Zheng³

et al. 2008

WJG

View full text Add to dashboard Cite

AIM:To investigate a new technique of the anorectal fistula treatment with acellular extracellular matrix (AEM). METHODS: Thirty patients with anorectal fistula were treated with AEM. All fistula tracts and primary openings were identified using conventional fistula probe. All tracts were curetted with curet and irrigated with hydrogen peroxide and metronidazole. The AEM was pulled into the fistula tract from secondary to primary opening. The material was secured at the level of the primary opening. The excess AEM was trimmed at skin level at the secondary opening. RESULTS: All of the 30 patients had successful closure of their fistula after a 7-14 d follow-up. The healing rate of anal fistula in treatment group was 100%. The ache time, healing time and anal deformation of treatment group were obviously superior to traditional surgical methods. CONCLUSION: Using AEM anal fistula plug in treatment that causes the anorectal fistula is safe and successful in 100% of patients. It can reduce pain, shorten disease course and protect anal function.

show abstract

Repair of fistulas-in-ano using autologous fibrin tissue adhesive

Cited by 102 publications

References 11 publications

Repair of Chronic Anorectal Fistulae Using Commercial Fibrin Sealant

Repair of Chronic Anorectal Fistulae Using Commercial Fibrin Sealant

Fibrin glue in the management of complex anal fistula

A anorectal fistula treatment with acellular extracellular matrix: A new technique

Contact Info

Product

Resources

About