Repair of DNA Double-Strand Breaks

Falk, Martin; Lukášová, Emı́lie; Kozubek, Stanislav

doi:10.1007/978-94-007-2564-5_20

Cited by 3 publications

(2 citation statements)

References 250 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The probability of repair of a complex damage may depend on the cell’s response to radiation, which involves specific biological mechanisms of damage repair35. Although the exact form of this dependence is unknown, the simplest function of probability, χ , can be introduced as a linear function of Y l ,…”

Section: Discussionmentioning

confidence: 99%

Multiscale approach predictions for biological outcomes in ion-beam cancer therapy

Verkhovtsev

Surdutovich

Solov’yov

2016

Sci Rep

131

View full text Add to dashboard Cite

Ion-beam therapy provides advances in cancer treatment, offering the possibility of excellent dose localization and thus maximising cell-killing within the tumour. The full potential of such therapy can only be realised if the fundamental mechanisms leading to lethal cell damage under ion irradiation are well understood. The key question is whether it is possible to quantitatively predict macroscopic biological effects caused by ion radiation on the basis of physical and chemical effects related to the ion-medium interactions on a nanometre scale. We demonstrate that the phenomenon-based MultiScale Approach to the assessment of radiation damage with ions gives a positive answer to this question. We apply this approach to numerous experiments where survival curves were obtained for different cell lines and conditions. Contrary to other, in essence empirical methods for evaluation of macroscopic effects of ionising radiation, the MultiScale Approach predicts the biodamage based on the physical effects related to ionisation of the medium, transport of secondary particles, chemical interactions, thermo-mechanical pathways of biodamage, and heuristic biological criteria for cell survival. We anticipate this method to give great impetus to the practical improvement of ion-beam cancer therapy and the development of more efficient treatment protocols.

show abstract

Section: Discussionmentioning

confidence: 99%

Multiscale approach predictions for biological outcomes in ion-beam cancer therapy

Verkhovtsev

Surdutovich

Solov’yov

2016

Sci Rep

131

View full text Add to dashboard Cite

show abstract

“…Within the neuronal nucleus, muskelin displayed a punctate distribution. Areas of highest muskelin intensities were frequently detected adjacent to foci of TO-PRO-3-labeled DNA (Figure 2D), representing potential regions of high chromatin density (Falk et al, 2008). We further performed electron microscopy (EM) to analyze cytoplasmic and nuclear muskelin at higher resolution.…”

Section: Myosin VI Associates With Dynein and Is Transported To The Neuronal Nucleusmentioning

confidence: 99%